In vitro metabolic stability and intestinal transport of P57AS3 (P57) from Hoodia gordonii and its interaction with drug metabolizing enzymes

Planta Medica

Volumn 74, Issue 10, 2008, Pages 1269-1275

  Madgula, Vamsi L M ^a   Avula, Bharathl ^a   Pawar, Rahul S ^a   Shukla, Yatin J ^b   Khan, Ikhlas A ^a,b   Walker, Larry A ^a,b   Khan, Shabana I ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Asclepiadaceae; CYP inhibition; Hoodia gordonii; Intestinal transport; Metabolic stability; P57

Indexed keywords

ANOREXIGENIC AGENT; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; P57AS3 GLYCOSIDE; PLANT EXTRACT; UNCLASSIFIED DRUG; VERAPAMIL; VERLUKAST;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ACTIVITY; DRUG METABOLISM; DRUG STABILITY; ENZYME ACTIVITY; HOODIA GORDONII; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTESTINE ABSORPTION; LIVER MICROSOME; MEDICINAL PLANT;

ASCLEPIADACEAE; CELL LINE, TUMOR; HUMANS; INTESTINES; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; PERMEABILITY; PLANT EXTRACTS;

APOCYNACEAE; CACTACEAE; HOODIA GORDONII;

EID: 50649101755     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1074580     Document Type: Article

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