Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study

Biomedical Chromatography

Volumn 27, Issue 12, 2013, Pages 1726-1732

  Vuppala, Pradeep K ^a   Jamalapuram, Seshulatha ^a   Furr, Edward B ^a   Mccurdy, Christopher R ^a   Avery, Bonnie A ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

7 hydroxymitragynine; Mass spectrometry; Method validation; mitragyna speciosa; Pharmacokinetics; Rats

Indexed keywords

ACETIC ACID; BODY FLUIDS; CHLORINE COMPOUNDS; ELECTROSPRAY IONIZATION; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; PHARMACOKINETICS;

7-HYDROXYMITRAGYNINE; INTERNAL STANDARDS; ITS APPLICATIONS; METHOD VALIDATIONS; MITRAGYNA SPECIOSA; OPIOIDS; PHARMACOKINETIC STUDIES; RAT PLASMA; SIMPLE++; UPLC-MS/MS;

RATS;

7 HYDROXYMITRAGYNINE; ACETIC ACID; ACETONITRILE; CHLOROFORM; MU OPIATE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROSPRAY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PLASMA; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

MITRAGYNA SPECIOSA; RATTUS;

7-HYDROXYMITRAGYNINE; MASS SPECTROMETRY; METHOD VALIDATION; MITRAGYNA SPECIOSA; PHARMACOKINETICS; RATS;

ANALGESICS, OPIOID; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SECOLOGANIN TRYPTAMINE ALKALOIDS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84887152353     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2986     Document Type: Article

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