An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis

Cancer Research

Volumn 72, Issue 12, 2012, Pages 3038-3047

  Huang, Xiumei ^a,b   Dong, Ying ^a,b   Bey, Erik A ^a,b   Kilgore, Jessica A ^a   Bair, Joseph S ^c   Li, Long Shan ^a,b   Patel, Malina ^a,b   Parkinson, Elizabeth I ^c   Wang, Yiguang ^a   Williams, Noelle S ^a   Gao, Jinming ^a   Hergenrother, Paul J ^c   Boothman, David A ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ANTINEOPLASTIC AGENT; BETA LAPACHONE; DEOXYNYBOQUINONE; DICOUMAROL; MENADIONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LETHALITY; LEWIS CARCINOMA; LIQUID CHROMATOGRAPHY; MOUSE; NECROSIS; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS; CALCIUM; CELL LINE, TUMOR; DNA DAMAGE; EGTAZIC ACID; HUMANS; NAD; NAD(P)H DEHYDROGENASE (QUINONE); NAPHTHOQUINONES; NECROSIS; NEOPLASMS; OXIDATION-REDUCTION; POLY(ADP-RIBOSE) POLYMERASES; QUINONES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84862566809     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-3135     Document Type: Article

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