Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner

Cell Death and Disease

Volumn 5, Issue 5, 2014, Pages

  Mnich, K ^a,b   Carleton, L A ^a   Kavanagh, E T ^a   Doyle, K M ^a   Samali, A ^a   Gorman, A M ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

Apoptosis; Autophagy; Caspases; Lysosomes; Nerve growth factor (NGF)

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 9; CHLOROQUINE; CONCANAMYCIN A; HEAT SHOCK COGNATE PROTEIN 70; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P17; PROTEIN TYROSINE KINASE A; X LINKED INHIBITOR OF APOPTOSIS; CHAPERONE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROGRANIN; PROTEASOME; THAPSIGARGIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; CELL DIFFERENTIATION; CELL MEMBRANE; CELL PROTECTION; CELL SURVIVAL; CHAPERONE-MEDIATED AUTOPHAGY; ENZYME ACTIVATION; LONG TERM SURVIVAL; LYSOSOME; MACROAUTOPHAGY; NONHUMAN; PC12 CELL LINE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; AUTOPHAGY; BIOCATALYSIS; DRUG EFFECTS; KINETICS; METABOLISM; MOUSE;

ANIMALS; APOPTOSIS; AUTOPHAGY; BIOCATALYSIS; CASPASE 3; CELL SURVIVAL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; KINETICS; LYSOSOMES; MICE; MOLECULAR CHAPERONES; NERVE GROWTH FACTOR; NEUROGRANIN; PC12 CELLS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RATS; RECEPTOR, TRKA; SIGNAL TRANSDUCTION; THAPSIGARGIN;

EID: 84901016764     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.173     Document Type: Article

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