The C-terminal threonine of Aβ43 nucleates toxic aggregation via structural and dynamical changes in monomers and protofibrils

Biochemistry

Volumn 53, Issue 19, 2014, Pages 3095-3105

  Conicella, Alexander E ^a   Fawzi, Nicolas L ^b  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; CHEMICAL MODIFICATION; NEURODEGENERATIVE DISEASES; RATE CONSTANTS;

AGGREGATION KINETICS; ALZHEIMERS DISEASE; C-TERMINUS; DIRECT CONTACT; PROTOFIBRILS; SATURATION TRANSFER; SCALAR COUPLING; TIME-COURSE EXPERIMENTS;

AMINO ACIDS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; THREONINE;

EID: 84901008835     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500131a     Document Type: Article

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