Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness

Nature Chemical Biology

Volumn 10, Issue 6, 2014, Pages 457-462

  Lolicato, Marco ^a   Bucchi, Annalisa ^a   Arrigoni, Cristina ^a   Zucca, Stefano ^a   Nardini, Marco ^a   Schroeder, Indra ^b   Simmons, Katie ^c   Aquila, Marco ^a   Difrancesco, Dario ^a   Bolognesi, Martino ^a,d   Schwede, Frank ^e   Kashin, Dmitry ^e   Fishwick, Colin W G ^c   Johnson, A Peter ^c   Thiel, Gerhard ^b   Moroni, Anna ^a,d  

^a UNIVERSITY OF MILAN   (Italy)

^b DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d CNR   (Italy)

^e Forschungslabor und Biochemica Vertrieb GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC DINUCLEOTIDE; DINUCLEOTIDE; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 4; UNCLASSIFIED DRUG;

ARTICLE; BETA ADRENERGIC STIMULATION; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HEART MUSCLE CELL; HEART RATE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SECOND MESSENGER; SINUS NODE;

MAMMALIA;

ANIMALS; BINDING SITES; BLOTTING, WESTERN; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; CYCLIC GMP; DINUCLEOSIDE PHOSPHATES; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; ION CHANNEL GATING; LIGANDS; MICE; MICE, INBRED C57BL; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; MUSCLE PROTEINS; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; SINOATRIAL NODE; SMALL MOLECULE LIBRARIES; TRANSFECTION;

EID: 84900987101     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1521     Document Type: Article

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