Changes in plasma and cerebrospinal fluid biomarkers in aged patients with early postoperative cognitive dysfunction following total hip-replacement surgery

Journal of Anesthesia

Volumn 27, Issue 2, 2013, Pages 236-242

  Ji, Mu Huo ^a   Yuan, Hong Mei ^b   Zhang, Guang Fen ^a   Li, Xiao Min ^a   Dong, Lin ^a   Li, Wei Yan ^a   Zhou, Zhi Qiang ^a   Yang, Jian Jun ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Biomarker; Cerebrospinal fluid; Plasma; Postoperative cognitive dysfunction; Spinal anesthesia

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; C REACTIVE PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; PHOSPHORYLATED TAU PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

AGED; ARTICLE; BLOOD SAMPLING; CEREBROSPINAL FLUID; COGNITION; DISEASE MARKER; FEMALE; GENERAL ANESTHESIA; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NEUROLOGIC EXAMINATION; OPERATION DURATION; POSTOPERATIVE COGNITIVE DYSFUNCTION; POSTOPERATIVE PERIOD; SPINAL ANESTHESIA; STUDENT T TEST; TOTAL HIP PROSTHESIS;

AGED; AGED, 80 AND OVER; AMYLOID BETA-PEPTIDES; ANESTHESIA, SPINAL; ARTHROPLASTY, REPLACEMENT, HIP; BIOLOGICAL MARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; C-REACTIVE PROTEIN; COGNITION DISORDERS; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MALE; MALONDIALDEHYDE; NEUROPSYCHOLOGICAL TESTS; PAIN, POSTOPERATIVE; PEPTIDE FRAGMENTS; POSTOPERATIVE COMPLICATIONS; PREDICTIVE VALUE OF TESTS; PSYCHOMOTOR PERFORMANCE; TAU PROTEINS;

EID: 84881557475     PISSN: 09138668     EISSN: 14388359     Source Type: Journal    
DOI: 10.1007/s00540-012-1506-3     Document Type: Article

References (23)

1. Steinmetz J, Christensen KB, Lund T, Lohse N, Rasmussen LS. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009;110(3):548-55.
2. Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, Maze M. Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol. 2010;68(3):360-8.
3. Sauër AM, Kalkman C, van Dijk D. Postoperative cognitive decline. J Anesth. 2009;23(2):256-9.
4. Monk TG, Weldon BC, Garvan CW, Dede DE, van der Aa MT, Gravenstein JS. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008;108(1):18-30.
5. Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, Rabbitt P, Jolles J, Larsen K, Hanning CD, Langeron O, Johnson T, Lauven PM, Kristensen PA, Biedler A, van Beem H, Fraidakis O, Silverstein JH, Beneken JE, Gravenstein JS. Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study. Lancet. 1998;351(9106):6857-61.
6. McDonagh DL, Mathew JP, White WD, Phillips-Bute B, Laskowitz DT, Podgoreanu MV, Newman MF, Neurologic Outcome Research Group. Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. Anesthesiology. 2010;112(4):852-9.
7. Li YC, Xi CH, An YF, Dong WH, Zhou M. Perioperative inflammatory response and protein S-100β concentrations - relationship with post-operative cognitive dysfunction in elderly patients. Acta Anaesthesiol Scand. 2012;56(5):595-600.
8. Fodale V, Santamaria LB, Schifilliti D, Mandal PK. Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer's disease. Anaesthesia. 2010;65(4):388-95.
9. Seidenberg M, O'Leary DS, Berent S, Boll T. Changes in seizure frequency and test-retest scores on the Wechsler Adult Intelligence Scale. Epilepsia. 1981;22:75-83.
10. Brickenkamp R. Test d2: Aufmerksamkeits-Belastungs-test manual. Gottingen: Hogrefe; 1994.
11. Oswald WD, Roth E. Der Zahlen-Verbindungs-Test (ZVT). Gottingen: Hogrefe; 1997.
12. Krenk L, Rasmussen LS, Kehlet H. New insights into the pathophysiology of postoperative cognitive dysfunction. Acta Anaesthesiol Scand. 2010;54(8):951-6.
13. Johnson T, Monk T, Rasmussen LS, Abildstrom H, Houx P, Korttila K, Kuipers HM, Hanning CD, Siersma VD, Kristensen D, Canet J, Ibañaz MT, Moller JT, ISPOCD2 Investigators. Postoperative cognitive dysfunction in middle-aged patients. Anesthesiology. 2002;96(6):1351-7.
14. Tang JX, Baranov D, Hammond M, Shaw LM, Eckenhoff MF, Eckenhoff RG. Human Alzheimer and inflammation biomarkers after anesthesia and surgery. Anesthesiology. 2011;115(4):727-32.
15. Humpel C. Identifying and validating biomarkers for Alzheimer's disease. Trends Biotechnol. 2011;29(1):26-32.
16. Mulder C, Verwey NA, van der Flier WM, Bouwman FH, Kok A, van Elk EJ, Scheltens P, Blankenstein MA. Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease. Clin Chem. 2010;56(2):248-53.
17. Hudetz JA, Gandhi SD, Iqbal Z, Patterson KM, Pagel PS. Elevated postoperative inflammatory biomarkers are associated with short- and medium-term cognitive dysfunction after coronary artery surgery. J Anesth. 2011;25(1):1-9.
18. Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, Maze M. Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci USA. 2010;107(47):20518-22.
19. Rudolph JL, Ramlawi B, Kuchel GA, McElhaney JE, Xie D, Sellke FW, Khabbaz K, Levkoff SE, Marcantonio ER. Chemokines are associated with delirium after cardiac surgery. J Gerontol A Biol Sci Med Sci. 2008;63(2):184-9.
20. Torres LL, Quaglio NB, de Souza GT, Bouwman FH, Kok A, van Elk EJ, Scheltens P, Blankenstein MA. Peripheral oxidative stress biomarkers in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2011;26(1):59-68.
21. Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski MH. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009;15(3):331-7.
22. Gunstad J, Benitez A, Smith J, Glickman E, Spitznagel MB, Alexander T, Juvancic-Heltzel J, Murray L. Serum brain-derived neurotrophic factor is associated with cognitive function in healthy older adults. J Geriatr Psychiatry Neurol. 2008;21(3):166-70.
23. Wang Y, Sands LP, Vaurio L, Mullen EA, Leung JM. The effects of postoperative pain and its management on postoperative cognitive dysfunction. Am J Geriatr Psychiatry. 2007;15(1):50-9.