The critical role of IL-15-PI3K-mTOR pathway in natural killer cell effector functions

Frontiers in Immunology

Volumn 5, Issue APR, 2014, Pages

  Nandagopal, Neethi ^a   Ali, Alaa Kassim ^a   Komal, Amandeep Kaur ^a   Lee, Seung Hwan ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

IL 15; JAK STAT pathway; MTOR pathway; Natural killer cells; Signal transduction

Indexed keywords

ALPHA INTERFERON; BETA ACTIN; GAMMA INTERFERON; GRANZYME B; IMMUNOGLOBULIN G1 ANTIBODY; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 4; JANUS KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOCLONAL ANTIBODY; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY A; PERFORIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN INHIBITOR OF ACTIVATED STAT; PROTEIN KINASE B; PROTEIN KINASE ZAP 70; PROTEIN S6; RAPAMYCIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRDU ASSAY; CELL STIMULATION; CELL SURVIVAL; CELL VIABILITY ASSAY; CONTROLLED STUDY; CYTOKINE INDUCED KILLER CELL; CYTOMEGALOVIRUS INFECTION; FLOW CYTOMETRY; INTRACELLULAR SIGNALING; MOUSE; MRNA EXPRESSION ASSAY; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NK CELL CULTURE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 84900848952     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00187     Document Type: Article

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