Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors, mitochondrial death pathway, and endoplasmic reticulum stress

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 8, 2014, Pages

  Dalal, Suman ^a   Zha, Qinqin ^a   Daniels, Christopher R ^a   Steagall, Rebecca J ^a   Joyner, William L ^a   Gadeau, Alain Pierre ^b   Singh, Mahipal ^a   Singh, Krishna ^a,c  

^a East Tennessee State University   (United States)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c EAST TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; CD44; ER stress; JNKs; Myocyte; Osteopontin

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BETA1 INTEGRIN; BETA3 INTEGRIN; CASPASE 12; CYTOCHROME C; GREEN FLUORESCENT PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HERMES ANTIGEN; OSTEOPONTIN; PROTEIN BAX; PROTEIN BCL 2; SALUBRINAL;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LYSATE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART RATE; HEART VENTRICLE EJECTION TIME; IN VITRO STUDY; IN VIVO STUDY; M MODE ECHOCARDIOGRAPHY; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; RELAXATION TIME; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; CD44; ER STRESS; JNKS; MYOCYTE; OSTEOPONTIN;

ANIMALS; ANTIGENS, CD44; APOPTOSIS; CASPASE 12; CASPASE INHIBITORS; ENDOPLASMIC RETICULUM STRESS; IN SITU NICK-END LABELING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; OSTEOPONTIN; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84900806855     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00954.2013     Document Type: Article

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