Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3

American Journal of Physiology - Endocrinology and Metabolism

Volumn 306, Issue 6, 2014, Pages

  Lateef, Dalya M ^a   Abreu Vieira, Gustavo ^b   Xiao, Cuiying ^a   Reitman, Marc L ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Bombesin receptor subtype 3; Brown adipose tissue; CL316243; MK 5046; Obesity; Sympathetic nervous system; Thermoregulation

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; BOMBESIN ANTAGONIST; BOMBESIN RECEPTOR SUBTYPE 3 AGONIST; MK 5046; UNCLASSIFIED DRUG;

ACUTE STRESS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN FUNCTION; BRAIN TISSUE; BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONTROLLED STUDY; DRUG EFFECT; HOMEOSTASIS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; THERMOGENESIS; WILD TYPE;

BOMBESIN RECEPTOR SUBTYPE-3; BROWN ADIPOSE TISSUE; CL316243; MK-5046; OBESITY; SYMPATHETIC NERVOUS SYSTEM; THERMOREGULATION;

ADIPOSE TISSUE, BROWN; ADRENERGIC BETA-3 RECEPTOR AGONISTS; ANIMALS; BODY TEMPERATURE REGULATION; COLD-SHOCK RESPONSE; CROSSES, GENETIC; DIOXOLES; EFFERENT PATHWAYS; ENERGY METABOLISM; HYPOTHALAMUS; IMIDAZOLES; INFUSIONS, INTRAVENOUS; INFUSIONS, INTRAVENTRICULAR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; NEURONS; PYRAZOLES; RECEPTORS, BOMBESIN; SYMPATHETIC NERVOUS SYSTEM; THERMOGENESIS;

EID: 84900563875     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00615.2013     Document Type: Article

References (37)

1. Bamshad M, Song CK, Bartness TJ. CNS origins of the sympathetic nervous system outflow to brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 276: R1569-R1578, 1999.
2. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 84: 277-359, 2004.
3. Castillo M, Hall JA, Correa-Medina M, Ueta C, Kang HW, Cohen DE, Bianco AC. Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes 60: 1082-1089, 2011.
4. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest 108: 1379-1385, 2001.
5. Enerback S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387: 90-94, 1997.
6. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110: 1093-1103, 2002.
7. Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. J Biol Chem 268: 5979-5984, 1993.
8. Franklin KB, Paxinos G. The Mouse Brain in Sterotaxic Coordinates. New York, NY: Elsevier, 2008.
9. Gordon CJ. Thermal physiology of laboratory mice: defining thermoneutrality. J Therm Biol 37: 654-685, 2012.
10. Guan XM, Chen H, Dobbelaar PH, Dong Y, Fong TM, Gagen K, Gorski J, He S, Howard AD, Jian T, Jiang M, Kan Y, Kelly TM, Kosinski J, Lin LS, Liu J, Marsh DJ, Metzger JM, Miller R, Nargund RP, Palyha O, Shearman L, Shen Z, Stearns R, Strack AM, Stribling S, Tang YS, Wang SP, White A, Yu H, Reitman ML. Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity. Cell Metab 11: 101-112, 2010.
11. Guan XM, Metzger JM, Yang L, Raustad KA, Wang SP, Spann SK, Kosinski JA, Yu H, Shearman LP, Faidley TD, Palyha O, Kan Y, Kelly TM, Sebhat I, Lin LS, Dragovic J, Lyons KA, Craw S, Nargund RP, Marsh DJ, Strack AM, Reitman ML. Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist. J Pharmacol Exp Ther 336: 356-364, 2011.
12. Harris RB. Parabiosis between db/db and ob/ob or db/+ mice. Endocrinology 140: 138-145, 1999.
13. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, Lubina JA, Patane J, Self B, Hunt P, McCamish M. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282: 1568-1575, 1999.
14. Ida T, Takahashi T, Tominaga H, Sato T, Sano H, Kume K, Ozaki M, Hiraguchi T, Shiotani H, Terajima S, Nakamura Y, Mori K, Yoshida M, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M. Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors. Front Endocrinol (Lausanne) 3: 177, 2012.
15. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 5: 415-425, 2007.
16. Jennings CA, Harrison DC, Maycox PR, Crook B, Smart D, Hervieu GJ. The distribution of the orphan bombesin receptor subtype-3 in the rat CNS. Neuroscience 120: 309-324, 2003.
17. Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev 60: 1-42, 2008.
18. Ladenheim EE, Hamilton NL, Behles RR, Bi S, Hampton LL, Battey JF, Moran TH. Factors contributing to obesity in bombesin receptor subtype-3-deficient mice. Endocrinology 149: 971-978, 2008.
19. Lee DL, Webb RC, Brands MW. Sympathetic and angiotensin-dependent hypertension during cage-switch stress in mice. Am J Physiol Regul Integr Comp Physiol 287: R1394-R1398, 2004.
20. Magoun HW, Harrison F, Broceck JR, Ranson SW. Activation of heat loss mechanisms by local heating of the brain. J Neurophysiol 1: 101-114, 1938.
21. Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT. Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. J Biol Chem 272: 26062-26071, 1997.
22. Metzger JM, Gagen K, Raustad KA, Yang L, White A, Wang SP, Craw S, Liu P, Lanza T, Lin LS, Nargund RP, Guan XM, Strack AM, Reitman ML. Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments. Am J Physiol Endocrinol Metab 299: E816-E824, 2010.
23. Morrison SF, Madden CJ, Tupone D. Central control of brown adipose tissue thermogenesis. Front Endocrinol (Lausanne) 3: pii: 00005, 2012.
24. Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 293: E444-E452, 2007.
25. Nikonova L, Koza RA, Mendoza T, Chao PM, Curley JP, Kozak LP. Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J 22: 3925-3937, 2008.
26. Ohki-Hamazaki H, Wada E, Matsui K, Wada K. Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse. Brain Res 762: 165-172, 1997.
27. Ohki-Hamazaki H, Watase K, Yamamoto K, Ogura H, Yamano M, Yamada K, Maeno H, Imaki J, Kikuyama S, Wada E, Wada K. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. Nature 390: 165-169, 1997.
28. Oka T, Oka K, Kobayashi T, Sugimoto Y, Ichikawa A, Ushikubi F, Narumiya S, Saper CB. Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors. J Physiol 551: 945-954, 2003.
29. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995.
30. Reitman ML, Dishy V, Moreau A, Denney WS, Liu C, Kraft WK, Mejia AV, Matson MA, Stoch SA, Wagner JA, Lai E. Pharmacokinetics and pharmacodynamics of MK-5046, a bombesin receptor subtype-3 (BRS-3) agonist, in healthy patients. J Clin Pharmacol 52: 1306-1316, 2012.
31. Rippe C, Berger K, Boiers C, Ricquier D, Erlanson-Albertsson C. Effect of high-fat diet, surrounding temperature, and enterostatin on uncoupling protein gene expression. Am J Physiol Endocrinol Metab 279: E293-E300, 2000.
32. Schwartz MW, Porte D Jr. Diabetes, obesity, and the brain. Science 307: 375-379, 2005.
33. Sebhat IK, Franklin C, Lo MC, Chen D, Jewell JP, Miller R, Pang J, Palyha O, Kan Y, Kelly TM, Guan XM, Marsh DJ, Kosinski JA, Metzger JM, Lyons K, Dragovic J, Guzzo PR, Henderson AJ, Reitman ML, Nargund RP, Wyvratt MJ, Lin LS. Discovery of MK-5046, a potent, selective bombesin receptor subtype-3 agonist for the treatment of obesity. ACS Med Chem Lett 2: 43-47, 2011.
34. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271, 1995.
35. Thomas SA, Palmiter RD. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature 387: 94-97, 1997.
36. Whittle A, Relat-Pardo J, Vidal-Puig A. Pharmacological strategies for targeting BAT thermogenesis. Trends Pharmacol Sci 34: 347-355, 2013.
37. Zhang L, Parks GS, Wang Z, Wang L, Lew M, Civelli O. Anatomical characterization of bombesin receptor subtype-3 mRNA expression in the rodent central nervous system. J Comp Neurol 521: 1020-1039, 2013.