Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration

American Journal of Physiology - Cell Physiology

Volumn 306, Issue 10, 2014, Pages

  Bae, Jiyoung ^a   Ricciardi, Carolyn J ^a   Esposito, Debora ^b   Komarnytsky, Slavko ^b   Hu, Pan ^a   Curry, Benjamin J ^a   Brown, Patricia L ^a   Gao, Zhanguo ^c   Biggerstaff, John P ^a   Chen, Jiangang ^a   Zhao, Ling ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Brown adipocytes; Brown adipose tissue; Inflammation; Pattern recognition receptor; UCP 1

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; ISOPRENALINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PATTERN RECOGNITION RECEPTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCOUPLING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; INFLAMMATION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY MECHANISM;

BROWN ADIPOCYTES; BROWN ADIPOSE TISSUE; INFLAMMATION; PATTERN RECOGNITION RECEPTOR; UCP-1;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ANIMALS; CELL LINE; CYTOKINES; DIET, HIGH-FAT; ELECTRON TRANSPORT; GENE EXPRESSION REGULATION; INFLAMMATION; ION CHANNELS; ISOPROTERENOL; MALE; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NOD1 SIGNALING ADAPTOR PROTEIN; NOD2 SIGNALING ADAPTOR PROTEIN; OBESITY; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84900554588     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00249.2013     Document Type: Article

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