Long-term memory deficits are associated with elevated synaptic ERK1/2 activation and reversed by mGluR5 antagonism in an animal model of autism

Neuropsychopharmacology

Volumn 39, Issue 7, 2014, Pages 1664-1673

  Seese, Ronald R ^a   Maske, Anna R ^a   Lynch, Gary ^a   Gall, Christine M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BTBR; cAMP response element binding protein (CREB); Fmr1 KO; MPEP; object location memory; positive AMPA receptor modulator (ampakine)

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; METABOTROPIC RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; 6-METHYL-2-(PHENYLETHYNYL)PYRIDINE; AMINO ACID RECEPTOR BLOCKING AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLODEXTRIN; DLGH4 PROTEIN, MOUSE; FMR1 PROTEIN, MOUSE; FRAGILE X MENTAL RETARDATION PROTEIN; GUANYLATE KINASE; MEMBRANE PROTEIN; PYRIDINE DERIVATIVE;

ADOLESCENT; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; AUTISM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HIPPOCAMPAL CA1 REGION; LONG TERM MEMORY; LONG TERM MEMORY DEFICIT; MALE; MEMORY; MENTAL PERFORMANCE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; OBJECT LOCATION MEMORY; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; SCORING SYSTEM; SIGNAL TRANSDUCTION; SYNAPSE; ANIMAL; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENETICS; HIPPOCAMPUS; INBRED MOUSE STRAIN; MAZE TEST; MEMORY DISORDERS; METABOLISM; PATHOLOGY; PHYSIOLOGY; STEREOTYPY;

ANIMALS; AUTISTIC DISORDER; CREB-BINDING PROTEIN; CYCLODEXTRINS; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; FRAGILE X MENTAL RETARDATION PROTEIN; GUANYLATE KINASE; HIPPOCAMPUS; MALE; MAP KINASE SIGNALING SYSTEM; MAZE LEARNING; MEMBRANE PROTEINS; MEMORY DISORDERS; MEMORY, LONG-TERM; MICE; MICE, INBRED STRAINS; PYRIDINES; STEREOTYPED BEHAVIOR; SYNAPSES;

EID: 84900554576     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2014.13     Document Type: Article

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