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Volumn 187, Issue 5, 2011, Pages 2548-2558

TLR6-driven lipid droplets in Mycobacterium leprae-infected Schwann cells: Immunoinflammatory platforms associated with bacterial persistence

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; FAT DROPLET; INTERLEUKIN 10; INTERLEUKIN 12P40; NITRIC OXIDE; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR 6;

EID: 80052689787     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101344     Document Type: Article
Times cited : (89)

References (55)
  • 1
    • 33847611889 scopus 로고    scopus 로고
    • Available at
    • World Health Organization. 2010. Leprosy Today. Available at: http://www.who.int/lep/en/.
    • (2010) Leprosy Today
  • 2
    • 0028361570 scopus 로고
    • Th1-Th2 paradigm: Insights from leprosy
    • Modlin, R. L. 1994. Th1-Th2 paradigm: insights from leprosy. J. Invest. Dermatol. 102: 828-832. (Pubitemid 24210374)
    • (1994) Journal of Investigative Dermatology , vol.102 , Issue.6 , pp. 828-832
    • Modlin, R.L.1
  • 4
    • 58149295904 scopus 로고    scopus 로고
    • Classification of leprosy into multibacillary and paucibacillary groups: An analysis
    • Parkash, O. 2009. Classification of leprosy into multibacillary and paucibacillary groups: an analysis. FEMS Immunol. Med. Microbiol. 55: 1-5.
    • (2009) FEMS Immunol. Med. Microbiol. , vol.55 , pp. 1-5
    • Parkash, O.1
  • 6
    • 0014862295 scopus 로고
    • Lipids in leprosy. 2. Histochemistry of lipids in human leprosy
    • Sakurai, I., and O. K. Skinsnes. 1970. Lipids in leprosy. 2. Histochemistry of lipids in human leprosy. Int. J. Lepr. Other Mycobact. Dis. 38: 389-403.
    • (1970) Int. J. Lepr. Other Mycobact. Dis. , vol.38 , pp. 389-403
    • Sakurai, I.1    Skinsnes, O.K.2
  • 7
    • 0021192136 scopus 로고
    • Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid
    • Mehra, V., P. J. Brennan, E. Rada, J. Convit, and B. R. Bloom. 1984. Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid. Nature 308: 194-196. (Pubitemid 14129561)
    • (1984) Nature , vol.308 , Issue.5955 , pp. 194-196
    • Mehra, V.1    Brennan, P.J.2    Rada, E.3
  • 9
    • 77649106927 scopus 로고    scopus 로고
    • Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
    • Mattos, K. A., H. D'Avila, L. S. Rodrigues, V. G. Oliveira, E. N. Sarno, G. C. Atella, G. M. Pereira, P. T. Bozza, and M. C. Pessolani. 2010. Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. J. Leukoc. Biol. 87: 371-384.
    • (2010) J. Leukoc. Biol. , vol.87 , pp. 371-384
    • Mattos, K.A.1    D'Avila, H.2    Rodrigues, L.S.3    Oliveira, V.G.4    Sarno, E.N.5    Atella, G.C.6    Pereira, G.M.7    Bozza, P.T.8    Pessolani, M.C.9
  • 10
    • 67349265997 scopus 로고    scopus 로고
    • Leukocyte lipid bodies - Biogenesis and functions in inflammation
    • Bozza, P. T., K. G. Magalhães, and P. F. Weller. 2009. Leukocyte lipid bodies - Biogenesis and functions in inflammation. Biochim. Biophys. Acta 1791: 540-551.
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 540-551
    • Bozza, P.T.1    Magalhães, K.G.2    Weller, P.F.3
  • 11
    • 70249083451 scopus 로고    scopus 로고
    • Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor gamma expression and activation: Functions in inflammation, lipid metabolism, and pathogenesis
    • Almeida, P. E., A. R. Silva, C. M. Maya-Monteiro, D. Töröcsik, H. D'Avila, B. Dezsö, K. G. Magalhães, H. C. Castro-Faria-Neto, L. Nagy, and P. T. Bozza. 2009. Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor gamma expression and activation: functions in inflammation, lipid metabolism, and pathogenesis. J. Immunol. 183: 1337-1345.
    • (2009) J. Immunol. , vol.183 , pp. 1337-1345
    • Almeida, P.E.1    Silva, A.R.2    Maya-Monteiro, C.M.3    Töröcsik, D.4    D'Avila, H.5    Dezsö, B.6    Magalhães, K.G.7    Castro-Faria-Neto, H.C.8    Nagy, L.9    Bozza, P.T.10
  • 12
    • 33644534811 scopus 로고    scopus 로고
    • Mycobacterium bovis bacillus Calmette-Guérin induces TLR2-mediated formation of lipid bodies: Intracellular domains for eicosanoid synthesis in vivo
    • D'Avila, H., R. C. N. Melo, G. G. Parreira, E. Werneck-Barroso, H. C. Castro-Faria-Neto, and P. T. Bozza. 2006. Mycobacterium bovis bacillus Calmette-Guérin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J. Immunol. 176: 3087-3097.
    • (2006) J. Immunol. , vol.176 , pp. 3087-3097
    • D'Avila, H.1    Melo, R.C.N.2    Parreira, G.G.3    Werneck-Barroso, E.4    Castro-Faria-Neto, H.C.5    Bozza, P.T.6
  • 13
    • 0025924175 scopus 로고
    • Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines
    • Betz, M., and B. S. Fox. 1991. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146: 108-113.
    • (1991) J. Immunol. , vol.146 , pp. 108-113
    • Betz, M.1    Fox, B.S.2
  • 15
    • 48349107532 scopus 로고    scopus 로고
    • Lipid bodies in innate immune response to bacterial and parasite infections
    • D'Avila, H., C. M. Maya-Monteiro, and P. T. Bozza. 2008. Lipid bodies in innate immune response to bacterial and parasite infections. Int. Immunopharmacol. 8: 1308-1315.
    • (2008) Int. Immunopharmacol. , vol.8 , pp. 1308-1315
    • D'Avila, H.1    Maya-Monteiro, C.M.2    Bozza, P.T.3
  • 16
    • 0030657639 scopus 로고    scopus 로고
    • The role of cytokines in Schwann cell damage, protection, and repair
    • Lisak, R. P., D. Skundric, B. Bealmear, and S. Ragheb. 1997. The role of cytokines in Schwann cell damage, protection, and repair. J. Infect. Dis. 176 (Suppl. 2): S173-S179. (Pubitemid 27505885)
    • (1997) Journal of Infectious Diseases , vol.176 , Issue.6 SUPPL.
    • Lisak, R.P.1    Skundric, D.2    Bealmear, B.3    Ragheb, S.4
  • 21
    • 61549129995 scopus 로고    scopus 로고
    • Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease
    • Martini, R., S. Fischer, R. López-Vales, and S. David. 2008. Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease. Glia 56: 1566-1577.
    • (2008) Glia , vol.56 , pp. 1566-1577
    • Martini, R.1    Fischer, S.2    López-Vales, R.3    David, S.4
  • 22
    • 78651466240 scopus 로고    scopus 로고
    • Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: A putative mechanism for host lipid acquisition and bacterial survival in phagosomes
    • Mattos, K. A., F. A. Lara, V. G. Oliveira, L. S. Rodrigues, H. D'Avila, R. C. Melo, P. P. Manso, E. N. Sarno, P. T. Bozza, and M. C. Pessolani. 2011. Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes. Cell. Microbiol. 13: 259-273.
    • (2011) Cell. Microbiol. , vol.13 , pp. 259-273
    • Mattos, K.A.1    Lara, F.A.2    Oliveira, V.G.3    Rodrigues, L.S.4    D'Avila, H.5    Melo, R.C.6    Manso, P.P.7    Sarno, E.N.8    Bozza, P.T.9    Pessolani, M.C.10
  • 24
    • 0016325178 scopus 로고
    • Histological classification and the immunological spectrum of leprosy
    • Ridley, D. S. 1974. Histological classification and the immunological spectrum of leprosy. Bull. World Health Organ. 51: 451-465.
    • (1974) Bull. World Health Organ. , vol.51 , pp. 451-465
    • Ridley, D.S.1
  • 26
    • 73649156930 scopus 로고
    • Zenker vs formalin fixation for the histopathology of leprosy tissues and other desirable features of technique
    • Wade, H. W. 1962. Zenker vs formalin fixation for the histopathology of leprosy tissues and other desirable features of technique. Int. J. Lepr. 30: 477-488.
    • (1962) Int. J. Lepr. , vol.30 , pp. 477-488
    • Wade, H.W.1
  • 27
    • 0038711498 scopus 로고    scopus 로고
    • A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system
    • DOI 10.1074/jbc.M301430200
    • Marchesan, D., M. Rutberg, L. Andersson, L. Asp, T. Larsson, J. Borén, B. R. Johansson, and S. O. Olofsson. 2003. A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system. J. Biol. Chem. 278: 27293-27300. (Pubitemid 36876887)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.29 , pp. 27293-27300
    • Marchesan, D.1    Rutberg, M.2    Andersson, L.3    Asp, L.4    Larsson, T.5    Boren, J.6    Johansson, B.R.7    Olofsson, S.-O.8
  • 29
    • 38349174747 scopus 로고    scopus 로고
    • Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism
    • Maya-Monteiro, C. M., P. E. Almeida, H. D'Avila, A. S. Martins, A. P. Rezende, H. Castro-Faria-Neto, and P. T. Bozza. 2008. Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism. J. Biol. Chem. 283: 2203-2210.
    • (2008) J. Biol. Chem. , vol.283 , pp. 2203-2210
    • Maya-Monteiro, C.M.1    Almeida, P.E.2    D'Avila, H.3    Martins, A.S.4    Rezende, A.P.5    Castro-Faria-Neto, H.6    Bozza, P.T.7
  • 31
    • 33845385196 scopus 로고    scopus 로고
    • Mycobacteria directly induce cytoskeletal rearrangements for macrophage spreading and polarization through TLR2-dependent PI3K signaling
    • DOI 10.1189/jlb.0106066
    • Lasunskaia, E. B., M. N. Campos, M. R. De Andrade, R. A. Damatta, T. L. Kipnis, M. Einicker-Lamas, and W. D. Da Silva. 2006. Mycobacteria directly induce cytoskeletal rearrangements for macrophage spreading and polarization through TLR2-dependent PI3K signaling. J. Leukoc. Biol. 80: 1480-1490. (Pubitemid 44904987)
    • (2006) Journal of Leukocyte Biology , vol.80 , Issue.6 , pp. 1480-1490
    • Lasunskaia, E.B.1    Campos, M.N.N.2    De Andrade, M.R.M.3    DaMatta, R.A.4    Kipnis, T.L.5    Einicker-Lamas, M.6    Da, S.W.D.7
  • 32
    • 55749099013 scopus 로고    scopus 로고
    • Neutrophils recruited to the site of Mycobacterium bovis BCG infection undergo apoptosis and modulate lipid body biogenesis and prostaglandin E production by macrophages
    • D'Avila, H., N. R. Roque, R. M. Cardoso, H. C. Castro-Faria-Neto, R. C. N. Melo, and P. T. Bozza. 2008. Neutrophils recruited to the site of Mycobacterium bovis BCG infection undergo apoptosis and modulate lipid body biogenesis and prostaglandin E production by macrophages. Cell. Microbiol. 10: 2589-2604.
    • (2008) Cell. Microbiol. , vol.10 , pp. 2589-2604
    • D'Avila, H.1    Roque, N.R.2    Cardoso, R.M.3    Castro-Faria-Neto, H.C.4    Melo, R.C.N.5    Bozza, P.T.6
  • 33
  • 34
    • 0037373014 scopus 로고    scopus 로고
    • Expression of toll-like receptor 2 on human schwann cells: A mechanism of nerve damage in leprosy
    • DOI 10.1128/IAI.71.3.1427-1433.2003
    • Oliveira, R. B., M. T. Ochoa, P. A. Sieling, T. H. Rea, A. Rambukkana, E. N. Sarno, and R. L. Modlin. 2003. Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy. Infect. Immun. 71: 1427-1433. (Pubitemid 36254329)
    • (2003) Infection and Immunity , vol.71 , Issue.3 , pp. 1427-1433
    • Oliveira, R.B.1    Ochoa, M.T.2    Sieling, P.A.3    Rea, T.H.4    Rambukkana, A.5    Sarno, E.N.6    Modlin, R.L.7
  • 36
    • 77249110401 scopus 로고    scopus 로고
    • The innate immune response in leprosy
    • Modlin, R. L. 2010. The innate immune response in leprosy. Curr. Opin. Immunol. 22: 48-54.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 48-54
    • Modlin, R.L.1
  • 39
    • 0023129883 scopus 로고
    • Mycobacterium leprae-burdened macrophages are refractory to activation by gamma interferon
    • Sibley, L. D., and J. L. Krahenbuhl. 1987. Mycobacterium leprae-burdened macrophages are refractory to activation by gamma interferon. Infect. Immun. 55: 446-450. (Pubitemid 17004126)
    • (1987) Infection and Immunity , vol.55 , Issue.2 , pp. 446-450
    • Sibley, L.D.1    Krahenbuhl, J.L.2
  • 40
    • 42149180028 scopus 로고    scopus 로고
    • TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells
    • Qin, Y., C. Cheng, H. Wang, X. Shao, Y. Gao, and A. Shen. 2008. TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells. Neurochem. Res. 33: 1077-1084.
    • (2008) Neurochem. Res. , vol.33 , pp. 1077-1084
    • Qin, Y.1    Cheng, C.2    Wang, H.3    Shao, X.4    Gao, Y.5    Shen, A.6
  • 41
    • 0032530667 scopus 로고    scopus 로고
    • TNF-alpha and TGF-beta act synergistically to kill Schwann cells
    • DOI 10.1002/(SICI)1097-4547(19980915)53:6<747::AID-JNR12>3.0.CO;2-V
    • Skoff, A. M., R. P. Lisak, B. Bealmear, and J. A. Benjamins. 1998. TNF-alpha and TGF-beta act synergistically to kill Schwann cells. J. Neurosci. Res. 53: 747-756. (Pubitemid 28423882)
    • (1998) Journal of Neuroscience Research , vol.53 , Issue.6 , pp. 747-756
    • Skoff, A.M.1    Lisak, R.P.2    Bealmear, B.3    Benjamins, J.A.4
  • 43
    • 0036800164 scopus 로고    scopus 로고
    • NS-398: Cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation
    • DOI 10.1054/plef.2002.0425
    • Bozza, P. T., P. Pacheco, W. Yu, and P. F. Weller. 2002. NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation. Prostaglandins Leukot. Essent. Fatty Acids 67: 237-244. (Pubitemid 35192168)
    • (2002) Prostaglandins Leukotrienes and Essential Fatty Acids , vol.67 , Issue.4 , pp. 237-244
    • Bozza, P.T.1    Pacheco, P.2    Yu, W.3    Weller, P.F.4
  • 50
    • 77950630894 scopus 로고    scopus 로고
    • Nuclear factor-kappaB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12: Role in neuronal toxicity
    • Alvarez, S., A. Blanco, M. Fresno, and M. A. Muñoz- Fernández. 2010. Nuclear factor-kappaB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12: role in neuronal toxicity. J. Neurochem. 113: 772-783.
    • (2010) J. Neurochem. , vol.113 , pp. 772-783
    • Alvarez, S.1    Blanco, A.2    Fresno, M.3    Muñoz-Fernández, M.A.4
  • 51
    • 34547592075 scopus 로고    scopus 로고
    • Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus
    • DOI 10.1099/vir.0.82898-0
    • Boulant, S., P. Targett-Adams, and J. McLauchlan. 2007. Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus. J. Gen. Virol. 88: 2204-2213. (Pubitemid 47194217)
    • (2007) Journal of General Virology , vol.88 , Issue.8 , pp. 2204-2213
    • Boulant, S.1    Targett-Adams, P.2    McLauchlan, J.3
  • 55
    • 69049108875 scopus 로고    scopus 로고
    • Foamy macrophages and the progression of the human tuberculosis granuloma
    • Russell, D. G., P. J. Cardona, M. J. Kim, S. Allain, and F. Altare. 2009. Foamy macrophages and the progression of the human tuberculosis granuloma. Nat. Immunol. 10: 943-948.
    • (2009) Nat. Immunol. , vol.10 , pp. 943-948
    • Russell, D.G.1    Cardona, P.J.2    Kim, M.J.3    Allain, S.4    Altare, F.5


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