Clofazimine Modulates the Expression of Lipid Metabolism Proteins in Mycobacterium leprae-Infected Macrophages

PLoS Neglected Tropical Diseases

Volumn 6, Issue 12, 2012, Pages

  Degang, Yang ^a,b   Akama, Takeshi ^a   Hara, Takeshi ^a   Tanigawa, Kazunari ^a   Ishido, Yuko ^a   Gidoh, Masaichi ^a   Makino, Masahiko ^a   Ishii, Norihisa ^a   Suzuki, Koichi ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b Shanghai Skin Disease Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOPHILIN; BETA INTERFERON; CELL PROTEIN; CLOFAZIMINE; DAPSONE; GAMMA INTERFERON; HORMONE SENSITIVE LIPASE; RIFAMPICIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LEPROSY; LIPID METABOLISM; LIPID STORAGE; LIPOLYSIS; MACROPHAGE; MYCOBACTERIUM LEPRAE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CLOFAZIMINE; DAPSONE; GENE EXPRESSION PROFILING; HUMANS; INTERFERONS; LEPROSTATIC AGENTS; LIPID METABOLISM; MACROPHAGES; MYCOBACTERIUM LEPRAE; RATS; RATS, NUDE; REAL-TIME POLYMERASE CHAIN REACTION; RIFAMPIN;

EID: 84872019068     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001936     Document Type: Article

References (39)

1. World Health Organization (2011) Leprosy update, 2011. Wkly Epidemiol Rec 86: 389-399.
2. Ridley DS, Jopling WH, (1966) Classification of leprosy according to immunity: A five-group system. Int J Lepr Other Mycobact Dis 34: 255-273.
3. Mattos KA, Lara FA, Oliveira VG, Rodrigues LS, D'Avila H, et al. (2011) Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes. Cell Microbiol 13: 259-273.
4. Mattos KA, Oliveira VG, D'Avila H, Rodrigues LS, Pinheiro RO, et al. (2011) TLR6-driven lipid droplets in Mycobacterium leprae-infected Schwann cells: immunoinflammatory platforms associated with bacterial persistence. J Immunol 187: 2548-2558.
5. Cardona PJ, Llatjos R, Gordillo S, Diaz J, Ojanguren I, et al. (2000) Evolution of granulomas in lungs of mice infected aerogenically with Mycobacterium tuberculosis. Scand J Immunol 52: 156-163.
6. Kondo E, Kanai K, (1976) Accumulation of cholesterol esters in macrophages incubated with mycobacteria in vitro. Jpn J Med Sci Biol 29: 123-137.
7. Suzuki K, Takeshita F, Nakata N, Ishii N, Makino M, (2006) Localization of CORO1A in the macrophages containing Mycobacterium leprae. Acta Histochem Cytochem 39: 107-112.
8. Tanigawa K, Suzuki K, Nakamura K, Akama T, Kawashima A, et al. (2008) Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophages infected with Mycobacterium leprae. FEMS Microbiol Lett 289: 72-79.
9. Blanchette-Mackie EJ, Dwyer NK, Barber T, Coxey RA, Takeda T, et al. (1995) Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. J Lipid Res 36: 1211-1226.
10. Brasaemle DL, Barber T, Wolins NE, Serrero G, Blanchette-Mackie EJ, et al. (1997) Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res 38: 2249-2263.
11. Miura S, Gan JW, Brzostowski J, Parisi MJ, Schultz CJ, et al. (2002) Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J Biol Chem 277: 32253-32257.
12. Wolins NE, Rubin B, Brasaemle DL, (2001) TIP47 associates with lipid droplets. J Biol Chem 276: 5101-5108.
13. Gao J, Ye H, Serrero G, (2000) Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids. J Cell Physiol 182: 297-302.
14. Serrero G, Frolov A, Schroeder F, Tanaka K, Gelhaar L, (2000) Adipose differentiation related protein: expression, purification of recombinant protein in Escherichia coli and characterization of its fatty acid binding properties. Biochim Biophys Acta 1488: 245-254.
15. Zimmermann R, Lass A, Haemmerle G, Zechner R, (2009) Fate of fat: the role of adipose triglyceride lipase in lipolysis. Biochim Biophys Acta 1791: 494-500.
16. Tanigawa K, Degang Y, Kawashima A, Akama T, Yoshihara A, et al. (2012) Essential role of hormone-sensitive lipase (HSL) in the maintenance of lipid storage in Mycobacterium leprae-infected macrophages. Microb Pathog 52: 285-291.
17. Yogi Y, Banba T, Kobayashi M, Katoh H, Jahan N, et al. (1999) Leprosy in hypertensive nude rats (SHR/NCrj-rnu). Int J Lepr Other Mycobact Dis 67: 435-445.
18. Yogi Y, Endoh M, Banba T, Kobayashi M, Katoh H, et al. (2002) Susceptibility to Mycobacterium leprae of congenic hypertensive nude rat (SHR/NCrj-rnu) and production of cytokine from the resident peritoneal macrophages. Jpn J Lepr 71: 39-45.
19. Akama T, Suzuki K, Tanigawa K, Kawashima A, Wu H, et al. (2009) Whole-genome tiling array analysis of Mycobacterium leprae RNA reveals high expression of pseudogenes and noncoding regions. J Bacteriol 191: 3321-3327.
20. Akama T, Tanigawa K, Kawashima A, Wu H, Ishii N, et al. (2010) Analysis of Mycobacterium leprae gene expression using DNA microarray. Microb Pathog 49: 181-185.
21. Tanigawa K, Suzuki K, Kimura H, Takeshita F, Wu H, et al. (2009) Tryptophan aspartate-containing coat protein (CORO1A) suppresses Toll-like receptor signalling in Mycobacterium leprae infection. Clin Exp Immunol 156: 495-501.
22. Akhtar LN, Qin H, Muldowney MT, Yanagisawa LL, Kutsch O, et al. (2010) Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages. J Immunol 185: 2393-2404.
23. Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, et al. (2011) NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-kappa B signaling pathways. Immunity 34: 854-865.
24. Sun Q, Sun L, Liu HH, Chen X, Seth RB, et al. (2006) The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24: 633-642.
25. Singh P, Cole ST, (2011) Mycobacterium leprae: genes, pseudogenes and genetic diversity. Future Microbiol 6: 57-71.
26. Akama T, Suzuki K, Tanigawa K, Nakamura K, Kawashima A, et al. (2010) Whole-genome expression analysis of Mycobacterium leprae and its clinical application. Jpn J Infect Dis 63: 387-392.
27. Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, et al. (2001) Massive gene decay in the leprosy bacillus. Nature 409: 1007-1011.
28. Barry VC, Belton JG, Conalty ML, Denneny JM, Edward DW, et al. (1957) A new series of phenazines (rimino-compounds) with high antituberculosis activity. Nature 179: 1013-1015.
29. Cholo MC, Steel HC, Fourie PB, Germishuizen WA, Anderson R, (2012) Clofazimine: current status and future prospects. J Antimicrob Chemother 67: 290-298.
30. Reddy VM, O'Sullivan JF, Gangadharam PR, (1999) Antimycobacterial activities of riminophenazines. J Antimicrob Chemother 43: 615-623.
31. Rodrigues LC, Lockwood D, (2011) Leprosy now: epidemiology, progress, challenges, and research gaps. Lancet Infect Dis 11: 464-470.
32. Britton WJ, Lockwood DN, (2004) Leprosy. Lancet 363: 1209-1219.
33. Shepard CC, Chang YT, (1964) Activity of Antituberculosis Drugs against Mycobacterium Leprae. Int J Lepr 32: 260-271.
34. Krajewska MM, Anderson R, (1993) An in vitro comparison of the effects of the prooxidative riminophenazines clofazimine and B669 on neutrophil phospholipase A2 activity and superoxide generation. J Infect Dis 167: 899-904.
35. Wadee AA, Kuschke RH, Dooms TG, (1995) The inhibitory effects of Mycobacterium tuberculosis on MHC class II expression by monocytes activated with riminophenazines and phagocyte stimulants. Clin Exp Immunol 100: 434-439.
36. Sarracent J, Finlay CM, (1982) The action of Clofazimine on the level of lysosomal enzymes of cultured macrophages. Clin Exp Immunol 48: 261-267.
37. Watson SR, Auclair LK, Collins FM, (1981) The effect of combined chemotherapy on suppressor T-cell activity in Mycobacterium simiae-infected mice. Immunology 43: 459-465.
38. Shen J, Liu M, Zhou M, Wengzhong L, (2009) Occurrence and management of leprosy reaction in China in 2005. Lepr Rev 80: 164-169.
39. Walker SL, Nicholls PG, Dhakal S, Hawksworth RA, Macdonald M, et al. (2011) A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment. PLoS Negl Trop Dis 5: e1041.