Inhibition of metabolism and growth of Mycobacterium leprae by gamma irradiation

International Journal of Leprosy and Other Mycobacterial Diseases

Volumn 68, Issue 1, 2000, Pages 1-10

  Adams, Linda B ^a   Soileau, Nashone A ^a   Battista, John R ^b   Krahenbuhl, James L ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; PALMITIC ACID;

ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERICIDAL ACTIVITY; COLONY FORMING UNIT; CONTROLLED STUDY; FOOT PAD; GAMMA IRRADIATION; MORPHOMETRICS; MYCOBACTERIUM; MYCOBACTERIUM LEPRAE; NONHUMAN; OXIDATION; RADIATION DOSE;

ANIMALS; COBALT RADIOISOTOPES; COLONY COUNT, MICROBIAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; LEPROSY; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, ELECTRON, SCANNING; MYCOBACTERIUM LEPRAE; PALMITIC ACID; SCINTILLATION COUNTING;

EID: 0034033493     PISSN: 0148916X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. ADAMS, L. B., GILLIS, T. P., HWANG, D. H. and KRAHENBUHL, J. L. Effects of essential fatty acid deficiency on prostaglandin E, production and cell-mediated immunity in a mouse model of leprosy. Infect. Immun. 65 (1997) 1152-1157.
2. CHEHL, S., RUBY, J., JOB, C. K. and HASTINGS, R. C. The growth of Mycobacterium leprae in nude mice. Lepr. Rev. 54 (1983) 283-304.
3. COLSTON, M. J. and HILSON, G. R. Growth of Mycobacterium leprae and M. marinum in congenitally athymic (nude) mice, nature 262 (1976) 736-741.
4. DIZDAROGLU, M. Formation of an 8-hydroxyguanine moiety in deoxyribonucleic acid on γ-irradiation in aqueous solution. Biochemistry 24 (1985) 4476-4481.
5. FRANZBLAU, S. G. Oxidation of palmitic acid by Mycobacterium leprae in an axenic medium. J. Clin. Microbiol. 26 (1988) 18-21.
6. FRANZBLAU, S. G. Drug susceptibility testing of Mycobacterium leprae in the BACTEC 460 system. Antimicrob. Agents Chemother. 33 (1989) 2115-2117.
7. FRANZBLAU, S. G. and HARRIS, E. B. Biophysical optima for metabolism of Mycobacterium leprae. J. Clin. Microbiol. 26 (1988) 1124-1129.
8. FUKUTOMI, Y, MCCORMICK G., PASQUA, J. P., KRAHENBUHL, J. L., TORATANI, S., MATSUKI, G. and MATSUOKA, M. Elongation of M. leprae in macrophages cultured in the presence of IL-10. (Abstract) Int. J. Lepr. 66 (1998) 119A.
9. HARIHARAN, P. V. and CERUTTI, P. A. Formation of γ-ray induced thimine damage in Micrococcus radiodurans. J. Mol. Biol. 66 (1972) 65-81.
10. HEIFETS, L. B., LINDHOLM-LEVY, P. J. and FLORY, M. Comparison of bacteriostatic and bactericidal activity or isoniazid and ethionamide against Mycobacterium avium and Mycobacterium tuberculosis. Am. Rev. Respir. Dis. 143 (1991) 268-270.
11. HUTCHINSON, F. Chemical changes induced in DNA by ionizing radiation. Prog. Nucl. Acid Res. Mol. Biol. 32(1985)115-154.
12. KRAHENBUHL, J. L. and ADAMS, L. B. The role of the macrophage in resistance to the leprosy bacillus. In: Macrophage-Pathogen Interactions. New York: Marcel Dekker, Inc., 1994, pp. 281-302.
13. KUCHINO, Y., MORI, F., KASAI, H., INOUE, H., IWAI, S., MIURA, K., OHTSUKA, E. and NISHIMURA, S. Misreading of DNA templates containing 8-hydroxyguanosine at the modified base and adjacent residues. Nature 327 (1987) 77-79.
14. LEVY, L. Death of Mycobacterium leprae in mice and the additional effect of dapsone administration. Proc. Soc. Exp. Bio. Med. 135 (1970) 745-749.
15. MARQUES, M. A. M., CHITALE, S., BRENNAN, P. J. and PESSOLANI, M. C. V. Mapping and identification of the major cell wall-associated components of Mycobacterium leprae. Infect. Immun. 66 (1998) 2625-2631.
16. RAMASESH, N., ADAMS, L. B., FRANZBLAU, S. G. and KRAHENBUHL, J. L Effects of activated macrophages on Mycobacterium leprae. Infect. Immun. 59 (1991) 2864-2869.
17. RAMASESH, N., HASTINGS, R. C. and KRAHENBUHL, J. L. Metabolism of Mycobacterium leprae in macrophages. Infect. Immun. 55 (1987) 1203-1206.
18. SHEPARD, C. C. The experimental disease that follows the injection of human leprosy bacilli into footpads of mice. J. Exp. Med. 112 (1960) 445-454.
19. SHEPARD, C. C., DRAPER, P., REES, R. J. and LOWE, C. Effect of purification steps on the immunogenicity of Mycobacterium leprae. Br. J. Exp. Pathol. 61 (1980) 376-379.
20. SHEPARD, C. C. and MACRAE, D. H. A method for counting acid-fast bacteria. Int. J. Lepr. 36 (1968) 78-82.
21. SHEPARD, C. C. and MCRAE, D. H. Mycobacterium leprae: viability at 0°C, 31°C, and during freezing. Int. J. Lepr. 33 (1965) 316-323.
22. SIBLEY, L. D., FRANZBLAU, S. G. and KRAHENBUHL, J. L. Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages. Infect. Immun. 55 (1987) 680-685.
23. SIBLEY, L. D. and KRAHENBUHL, J. L. Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae. Infect. Immun. 56 (1988) 1912-1919.
24. STANFORD, J. L. Skin testing with mycobacterial reagents in leprosy. Tuberc. Lung Dis. 65 (1984) 63-74.
25. TRUMAN, R. and SANCHEZ, R. Armadillos: models for leprosy. Lab. Anim. 22 (1993) 28-32.
26. VAN HEMMEN, J. J. and BLEICHRODT, J. F. The decomposition of adenine by ionizing radiation. Radiat. Res. 46 (1971) 444-456.
27. WEIR, R. E., BRENNAN, P. J., BUTLIN, C. R. and DOCKRELL, H. M. Use of a whole blood assay to evaluate in vitro T cell responses to new leprosy skin test antigens in leprosy patients and healthy subjects. Clin. Exp. Immunol. 116 (1999) 263-269.