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Volumn 306, Issue 6, 2014, Pages

Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models

Author keywords

Sarcopenia; Ubiquitin

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EXERCISE; GLUCOSE TOLERANCE; HYPERGLYCEMIA; INSULIN RESISTANCE; MALE; MOUSE; MUSCLE GROWTH; MUSCLE MASS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RUNNING; SKELETAL MUSCLE; TREADMILL;

EID: 84900543714     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00277.2013     Document Type: Article
Times cited : (78)

References (65)
  • 1
    • 84892530909 scopus 로고    scopus 로고
    • Glycolytic fast-twitch muscle fiber restoration counters adverse agerelated changes in body composition and metabolism
    • Akasaki Y, Ouchi N, Izumiya Y, Bernardo BL, Lebrasseur NK, Walsh K. Glycolytic fast-twitch muscle fiber restoration counters adverse agerelated changes in body composition and metabolism. Aging Cell 13: 80-91, 2014.
    • (2014) Aging Cell , vol.13 , pp. 80-91
    • Akasaki, Y.1    Ouchi, N.2    Izumiya, Y.3    Bernardo, B.L.4    Lebrasseur, N.K.5    Walsh, K.6
  • 3
    • 0021135517 scopus 로고
    • A histochemical and morphological study of skeletal muscle from obese hyperglycaemic ob/ob mice
    • Almond RE, Enser M. A histochemical and morphological study of skeletal muscle from obese hyperglycaemic ob/ob mice. Diabetologia 27: 407-413, 1984.
    • (1984) Diabetologia , vol.27 , pp. 407-413
    • Almond, R.E.1    Enser, M.2
  • 5
    • 33646395381 scopus 로고    scopus 로고
    • Skeletal muscle protein anabolic response to increased energy and insulin is preserved in poorly controlled type 2 diabetes
    • Bell JA, Volpi E, Fujita S, Cadenas JG, Sheffield-Moore M, Rasmussen BB. Skeletal muscle protein anabolic response to increased energy and insulin is preserved in poorly controlled type 2 diabetes. J Nutr 136: 1249-1255, 2006.
    • (2006) J Nutr , vol.136 , pp. 1249-1255
    • Bell, J.A.1    Volpi, E.2    Fujita, S.3    Cadenas, J.G.4    Sheffield-Moore, M.5    Rasmussen, B.B.6
  • 7
    • 0036750177 scopus 로고    scopus 로고
    • Regulation of myoplasmic Ca 2+ in genetically obese (ob/ob) mouse single skeletal muscle fibres
    • Bruton J, Katz A, Abbate F, Westerblad H. Regulation of myoplasmic Ca 2+ in genetically obese (ob/ob) mouse single skeletal muscle fibres. Pflugers Arch 444: 692-699, 2002.
    • (2002) Pflugers Arch , vol.444 , pp. 692-699
    • Bruton, J.1    Katz, A.2    Abbate, F.3    Westerblad, H.4
  • 9
    • 0014806399 scopus 로고
    • Studies in the diabetic mutant mouse: V. Glucose tolerance in mice homozygous and heterozygous for the diabetes gene
    • Chick W, Lavine R, Like A. Studies in the diabetic mutant mouse: V. Glucose tolerance in mice homozygous and heterozygous for the diabetes gene. Diabetologia 6: 257-262, 1970.
    • (1970) Diabetologia , vol.6 , pp. 257-262
    • Chick, W.1    Lavine, R.2    Like, A.3
  • 10
    • 0346101486 scopus 로고    scopus 로고
    • Macrophages in mouse type 2 diabetic nephropathy: Correlation with diabetic state and progressive renal injury
    • Chow F, Ozols E, Nikolic-Paterson DJ, Atkins RC, Tesch GH. Macrophages in mouse type 2 diabetic nephropathy: Correlation with diabetic state and progressive renal injury. Kidney Int 65: 116-128, 2004.
    • (2004) Kidney Int , vol.65 , pp. 116-128
    • Chow, F.1    Ozols, E.2    Nikolic-Paterson, D.J.3    Atkins, R.C.4    Tesch, G.H.5
  • 11
    • 0016289615 scopus 로고
    • Hyperinsulinemia in pre-weaning diabetes (db) mice
    • Coleman DL, Hummel KP. Hyperinsulinemia in pre-weaning diabetes (db) mice. Diabetologia 10: 607-610, 1974.
    • (1974) Diabetologia , vol.10 , pp. 607-610
    • Coleman, D.L.1    Hummel, K.P.2
  • 12
    • 0344412857 scopus 로고    scopus 로고
    • Diabetes is associated with subclinical functional limitation in nondisabled older individuals: The Health, Aging, and Body Composition study
    • De Rekeneire N, Resnick HE, Schwartz AV, Shorr RI, Kuller LH, Simonsick EM, Vellas B, Harris TB. Diabetes is associated with subclinical functional limitation in nondisabled older individuals: the Health, Aging, and Body Composition study. Diabetes Care 26: 3257-3263, 2003.
    • (2003) Diabetes Care , vol.26 , pp. 3257-3263
    • De Rekeneire, N.1    Resnick, H.E.2    Schwartz, A.V.3    Shorr, R.I.4    Kuller, L.H.5    Simonsick, E.M.6    Vellas, B.7    Harris, T.B.8
  • 13
    • 0018103123 scopus 로고
    • General characteristics of protein degradation in diabetes and starvation
    • Dice JF, Walker CD, Byrne B, Cardiel A. General characteristics of protein degradation in diabetes and starvation. Proc Natl Acad Sci USA 75: 2093-2097, 1978.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 2093-2097
    • Dice, J.F.1    Walker, C.D.2    Byrne, B.3    Cardiel, A.4
  • 14
    • 0021063044 scopus 로고
    • Temporal changes in pancreatic islet composition in C57BL/6J-db/db (diabetes) mice
    • Gapp DA, Leiter EH, Coleman DL, Schwizer RW. Temporal changes in pancreatic islet composition in C57BL/6J-db/db (diabetes) mice. Diabetologia 25: 439-443, 1983.
    • (1983) Diabetologia , vol.25 , pp. 439-443
    • Gapp, D.A.1    Leiter, E.H.2    Coleman, D.L.3    Schwizer, R.W.4
  • 17
    • 0036328175 scopus 로고    scopus 로고
    • Synthesis rate of muscle proteins, muscle functions, and amino acid kinetics in type 2 diabetes
    • Halvatsiotis P, Short KR, Bigelow M, Nair KS. synthesis rate of muscle proteins, muscle functions, and amino acid kinetics in type 2 diabetes. Diabetes 51: 2395-2404, 2002.
    • (2002) Diabetes , vol.51 , pp. 2395-2404
    • Halvatsiotis, P.1    Short, K.R.2    Bigelow, M.3    Nair, K.S.4
  • 19
    • 34948834713 scopus 로고    scopus 로고
    • PTEN expression contributes to the regulation of muscle protein degradation in diabetes
    • Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J, Mitch WE. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes 56: 2449-2456, 2007.
    • (2007) Diabetes , vol.56 , pp. 2449-2456
    • Hu, Z.1    Lee, I.H.2    Wang, X.3    Sheng, H.4    Zhang, L.5    Du, J.6    Mitch, W.E.7
  • 20
    • 70349658713 scopus 로고    scopus 로고
    • Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice
    • Hu Z, Wang H, Lee IH, Du J, Mitch WE. Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice. J Clin Invest 119: 3059-3069, 2009.
    • (2009) J Clin Invest , vol.119 , pp. 3059-3069
    • Hu, Z.1    Wang, H.2    Lee, I.H.3    Du, J.4    Mitch, W.E.5
  • 21
    • 0000736325 scopus 로고
    • Obese, a new mutation in the house mouse
    • Ingalls AM, Dickie MM, Snell GD. Obese, a new mutation in the house mouse. J Hered 41: 317-318, 1950.
    • (1950) J Hered , vol.41 , pp. 317-318
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 23
    • 0036246979 scopus 로고    scopus 로고
    • Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
    • Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50: 889-896, 2002.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 889-896
    • Janssen, I.1    Heymsfield, S.B.2    Ross, R.3
  • 24
    • 13844262626 scopus 로고    scopus 로고
    • Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice
    • Kawasaki F, Matsuda M, Kanda Y, Inoue H, Kaku K. Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice. Am J Physiol Endocrinol Metab 288: E510-E518, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Kawasaki, F.1    Matsuda, M.2    Kanda, Y.3    Inoue, H.4    Kaku, K.5
  • 25
    • 68949151833 scopus 로고    scopus 로고
    • Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse
    • Kemp JG, Blazev R, Stephenson DG, Stephenson GMM. Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse. Int J Obes 33: 831-841, 2009.
    • (2009) Int J Obes , vol.33 , pp. 831-841
    • Kemp, J.G.1    Blazev, R.2    Stephenson, D.G.3    Stephenson, G.M.M.4
  • 26
    • 84900561109 scopus 로고    scopus 로고
    • The TALLYHO mouse as a model of human type 2 diabetes
    • In: edited by Joost H-G, Al-Hasani H, Schürmann A. Clifton, NJ: Humana
    • Kim JH, Saxton AM. The TALLYHO mouse as a model of human type 2 diabetes. In: Animal Models in Diabetes Research, edited by Joost H-G, Al-Hasani H, Schürmann A. Clifton, NJ: Humana, p. 75-87, 2013.
    • (2013) Animal Models in Diabetes Research , pp. 75-87
    • Kim, J.H.1    Saxton, A.M.2
  • 29
    • 0030819034 scopus 로고    scopus 로고
    • Effects of an intervention by a diabetes team in hospitalized patients with diabetes
    • Koproski J, Pretto Z, Poretsky L. Effects of an intervention by a diabetes team in hospitalized patients with diabetes. Diabetes Care 20: 1553-1555, 1997.
    • (1997) Diabetes Care , vol.20 , pp. 1553-1555
    • Koproski, J.1    Pretto, Z.2    Poretsky, L.3
  • 30
    • 78751485448 scopus 로고    scopus 로고
    • Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways
    • Long YC, Cheng Z, Copps KD, White MF. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Mol Cell Biol 31: 430-441, 2011.
    • (2011) Mol Cell Biol , vol.31 , pp. 430-441
    • Long, Y.C.1    Cheng, Z.2    Copps, K.D.3    White, M.F.4
  • 31
    • 44449176116 scopus 로고    scopus 로고
    • The muscle protein synthetic response to carbohydrate and protein ingestion is not impaired in men with longstanding type 2 diabetes
    • Manders RJ, Koopman R, Beelen M, Gijsen AP, Wodzig WK, Saris WH, Loon van LJ. The muscle protein synthetic response to carbohydrate and protein ingestion is not impaired in men with longstanding type 2 diabetes. J Nutr 138: 1079-1085, 2008.
    • (2008) J Nutr , vol.138 , pp. 1079-1085
    • Manders, R.J.1    Koopman, R.2    Beelen, M.3    Gijsen, A.P.4    Wodzig, W.K.5    Saris, W.H.6    van Loon, L.J.7
  • 32
    • 25644444543 scopus 로고    scopus 로고
    • Diabetes mellitus is associated with an increased risk of falls in elderly residents of a long-term care facility
    • Maurer MS, Burcham J, Cheng H. Diabetes mellitus is associated with an increased risk of falls in elderly residents of a long-term care facility. J Gerontol A Biol Sci Med Sci 60: 1157-1162, 2005.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 1157-1162
    • Maurer, M.S.1    Burcham, J.2    Cheng, H.3
  • 33
    • 50049120029 scopus 로고    scopus 로고
    • Sarcopenia: Diagnosis and treatment
    • Morley JE. Sarcopenia: diagnosis and treatment. J Nutr Health Aging 12: 452-456, 2008.
    • (2008) J Nutr Health Aging , vol.12 , pp. 452-456
    • Morley, J.E.1
  • 34
    • 84860406420 scopus 로고    scopus 로고
    • Impaired muscle regeneration in ob/ob and db/db mice
    • Nguyen MH, Cheng M, Koh TJ. Impaired muscle regeneration in ob/ob and db/db mice. Sci World J 11: 1525-1535, 2011.
    • (2011) Sci World J , vol.11 , pp. 1525-1535
    • Nguyen, M.H.1    Cheng, M.2    Koh, T.J.3
  • 35
    • 77953027226 scopus 로고    scopus 로고
    • Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: Evidence for decreased protein synthesis and not increased degradation
    • O'Neill ED, Wilding JPH, Kahn CR, Van Remmen H, McArdle A, Jackson MJ, Close GL. Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation. Age Dordr Neth 32: 209-222, 2010.
    • (2010) Age Dordr Neth , vol.32 , pp. 209-222
    • O'Neill, E.D.1    Wilding, J.P.H.2    Kahn, C.R.3    Van Remmen, H.4    McArdle, A.5    Jackson, M.J.6    Close, G.L.7
  • 36
    • 0020987544 scopus 로고
    • Protein metabolism in skeletal muscle, diaphragm, and heart of diabetic rats
    • Pain VM, Albertse EC, Garlick PJ. Protein metabolism in skeletal muscle, diaphragm, and heart of diabetic rats. Am J Physiol Endocrinol Metab 245: E604-E610, 1983.
    • (1983) Am J Physiol Endocrinol Metab , vol.245
    • Pain, V.M.1    Albertse, E.C.2    Garlick, P.J.3
  • 40
    • 0029741353 scopus 로고    scopus 로고
    • Role of different proteolytic pathways in degradation of muscle protein from streptozotocin-diabetic rats
    • Pepato MT, Migliorini RH, Goldberg AL, Kettelhut IC. Role of different proteolytic pathways in degradation of muscle protein from streptozotocin-diabetic rats. Am J Physiol Endocrinol Metab 271: E340-E347, 1996.
    • (1996) Am J Physiol Endocrinol Metab , vol.271
    • Pepato, M.T.1    Migliorini, R.H.2    Goldberg, A.L.3    Kettelhut, I.C.4
  • 41
    • 0029861468 scopus 로고    scopus 로고
    • Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription
    • Price SR, Bailey JL, Wang X, Jurkovitz C, England BK, Ding X, Phillips LS, Mitch WE. Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription. J Clin Invest 98: 1703-1708, 1996.
    • (1996) J Clin Invest , vol.98 , pp. 1703-1708
    • Price, S.R.1    Bailey, J.L.2    Wang, X.3    Jurkovitz, C.4    England, B.K.5    Ding, X.6    Phillips, L.S.7    Mitch, W.E.8
  • 42
    • 0022039121 scopus 로고
    • Muscle growth and satellite cell proliferative activity in obese (ob/ob) mice
    • Purchas RW, Romsos DR, Allen RE, Merkel RA. Muscle growth and satellite cell proliferative activity in obese (ob/ob) mice. J Anim Sci 60: 644-651, 1985.
    • (1985) J Anim Sci , vol.60 , pp. 644-651
    • Purchas, R.W.1    Romsos, D.R.2    Allen, R.E.3    Merkel, R.A.4
  • 43
    • 84900535789 scopus 로고    scopus 로고
    • Bethesda, MD: Natl. Institutes of Health
    • Rasband WS. ImageJ. Bethesda, MD: Natl. Institutes of Health.
    • ImageJ.
    • Rasband, W.S.1
  • 47
    • 0033786596 scopus 로고    scopus 로고
    • Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice
    • Shao J, Yamashita H, Qiao L, Friedman JE. Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice. J Endocrinol 167: 107-115, 2000.
    • (2000) J Endocrinol , vol.167 , pp. 107-115
    • Shao, J.1    Yamashita, H.2    Qiao, L.3    Friedman, J.E.4
  • 48
    • 0018083176 scopus 로고
    • Peripheral neuropathy in mutant diabetic mouse [C57BL/Ks (db/db)]
    • Sima AAF, Robertson DM. Peripheral neuropathy in mutant diabetic mouse [C57BL/Ks (db/db)]. Acta Neuropathol (Berl) 41: 85-89, 1978.
    • (1978) Acta Neuropathol (Berl) , vol.41 , pp. 85-89
    • Sima, A.A.F.1    Robertson, D.M.2
  • 50
    • 71249106254 scopus 로고    scopus 로고
    • Chronic high fat feeding attenuates load-induced hypertrophy in mice
    • Sitnick M, Bodine SC, Rutledge JC. Chronic high fat feeding attenuates load-induced hypertrophy in mice. J Physiol 587: 5753-5765, 2009.
    • (2009) J Physiol , vol.587 , pp. 5753-5765
    • Sitnick, M.1    Bodine, S.C.2    Rutledge, J.C.3
  • 51
    • 0024442483 scopus 로고
    • Skeletal muscle proteolysis in rats with acute streptozocin-induced diabetes
    • Smith OLK, Wong CY, Gelfand RA. Skeletal muscle proteolysis in rats with acute streptozocin-induced diabetes. Diabetes 38: 1117-1122, 1989.
    • (1989) Diabetes , vol.38 , pp. 1117-1122
    • Smith, O.L.K.1    Wong, C.Y.2    Gelfand, R.A.3
  • 52
    • 78650214179 scopus 로고    scopus 로고
    • Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using (C57BL/6J TALLYHO/JngJ) F2 mice (Abstract)
    • Stewart TP, Kim HY, Saxton AM, Kim JH. Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using (C57BL/6J TALLYHO/JngJ) F2 mice (Abstract). BMC Genomics 11: 713, 2010.
    • (2010) BMC Genomics , vol.11 , pp. 713
    • Stewart, T.P.1    Kim, H.Y.2    Saxton, A.M.3    Kim, J.H.4
  • 53
    • 0028308233 scopus 로고
    • Inability of muscles in the obese mouse (ob/ob) to respond to changes in body weight and activity
    • Stickland NC, Batt RA, Crook AR, Sutton CM. Inability of muscles in the obese mouse (ob/ob) to respond to changes in body weight and activity. J Anat 184: 527-533, 1994.
    • (1994) J Anat , vol.184 , pp. 527-533
    • Stickland, N.C.1    Batt, R.A.2    Crook, A.R.3    Sutton, C.M.4
  • 56
    • 23744512891 scopus 로고    scopus 로고
    • Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: The health, aging, and body composition study
    • Strotmeyer ESCJ
    • Strotmeyer ESCJ. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch Intern Med 165: 1612-1617, 2005.
    • (2005) Arch Intern Med , vol.165 , pp. 1612-1617
  • 57
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7: 85-96, 2006.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 58
    • 0026560730 scopus 로고
    • Pancreatic islets of obese hyperglycemic mice (ob/ob)
    • Tomita T, Doull V, Pollock HG, Krizsan D. Pancreatic islets of obese hyperglycemic mice (ob/ob). Pancreas 7: 367-375, 1992.
    • (1992) Pancreas , vol.7 , pp. 367-375
    • Tomita, T.1    Doull, V.2    Pollock, H.G.3    Krizsan, D.4
  • 59
    • 33845401821 scopus 로고    scopus 로고
    • Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance
    • Turpin SM, Lancaster GI, Darby I, Febbraio MA, Watt MJ. Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am J Physiol Endocrinol Metab 291: E1341-E1350, 2006.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Turpin, S.M.1    Lancaster, G.I.2    Darby, I.3    Febbraio, M.A.4    Watt, M.J.5
  • 62
    • 33747619854 scopus 로고    scopus 로고
    • Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling
    • Wang X, Hu Z, Hu J, Du J, Mitch WE. Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology 147: 4160-4168, 2006.
    • (2006) Endocrinology , vol.147 , pp. 4160-4168
    • Wang, X.1    Hu, Z.2    Hu, J.3    Du, J.4    Mitch, W.E.5
  • 63
    • 0033860107 scopus 로고    scopus 로고
    • Functional and histological characteristics of skeletal muscle and the effects of leptin in the genetically obese (ob/ob) mouse
    • Warmington SA, Tolan R, McBennett S. Functional and histological characteristics of skeletal muscle and the effects of leptin in the genetically obese (ob/ob) mouse. Int J Obes Relat Metab Disord J Int Assoc Study Obes 24: 1040-1050, 2000.
    • (2000) Int J Obes Relat Metab Disord J Int Assoc Study Obes , vol.24 , pp. 1040-1050
    • Warmington, S.A.1    Tolan, R.2    McBennett, S.3
  • 64
    • 0029022262 scopus 로고
    • Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation
    • Wing SS, Haas AL, Goldberg AL. Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation. Biochem J 307: 639-645, 1995.
    • (1995) Biochem J , vol.307 , pp. 639-645
    • Wing, S.S.1    Haas, A.L.2    Goldberg, A.L.3


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