Dickkopf-1, the Wnt antagonist, is induced by acidic pH and mediates epithelial cellular senescence in human reflux esophagitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 306, Issue 7, 2014, Pages

  Lyros, Orestis ^a   Rafiee, Parvaneh ^a   Nie, Linghui ^a   Medda, Rituparna ^a   Jovanovic, Nebojsa ^a   Schmidt, Jamie ^a   Mackinnon, Alexander ^a   Venu, Nanda ^a   Shaker, Reza ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Dickkopf 1; Esophagitis; Gastroesophageal reflux disease; Wnt

Indexed keywords

BETA CATENIN; BETA GALACTOSIDASE; DICKKOPF 1 PROTEIN; PROTEIN P16; WNT PROTEIN;

ABDOMINAL PAIN; ACIDITY; ADULT; AGED; APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL DAMAGE; CELL GROWTH; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DNA DAMAGE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; ESOPHAGUS BIOPSY; ESOPHAGUS MUCOSA; ESOPHAGUS PH; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GASTROESOPHAGEAL REFLUX; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IRON DEFICIENCY ANEMIA; MALE; MIDDLE AGED; NUCLEOTIDE SEQUENCE; ODYNOPHAGIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REFLUX ESOPHAGITIS; SQUAMOUS EPITHELIUM; UPREGULATION; VITAMIN DEFICIENCY; WESTERN BLOTTING; WNT SIGNALING PATHWAY;

DICKKOPF-1; ESOPHAGITIS; GASTROESOPHAGEAL REFLUX DISEASE; WNT;

ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; BETA-GALACTOSIDASE; CASE-CONTROL STUDIES; CELL AGING; CELL CYCLE CHECKPOINTS; CELL LINE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EPITHELIAL CELLS; ESOPHAGITIS, PEPTIC; ESOPHAGUS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; MUCOUS MEMBRANE; RNA INTERFERENCE; TIME FACTORS; TRANSFECTION; UP-REGULATION; WNT SIGNALING PATHWAY; YOUNG ADULT;

EID: 84900542202     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00153.2013     Document Type: Article

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