The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair

Gastroenterology

Volumn 141, Issue 1, 2011, Pages

  Koch, Stefan ^a   Nava, Porfirio ^a   Addis, Caroline ^a   Kim, Wooki ^a   Denning, Timothy L ^a   Li, Linheng ^b   Parkos, Charles A ^a   Nusrat, Asma ^a,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c Whitehead Rearch Building ^*  (United States)

Author keywords

Crohn's Disease; IBD; Intestinal Cell Signaling; Mucosa

Indexed keywords

AZOXYMETHANE; BETA CATENIN; BROXURIDINE; DEXTRAN SULFATE; DICKKOPF 1 PROTEIN; DICKKOPF 1 PROTEIN ANTIBODY; DRINKING WATER; GLYCOPROTEIN P INHIBITOR; PROTEIN C JUN; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG; WNT PROTEIN;

ADULT; ARTICLE; CELL ISOLATION; CELL PROLIFERATION; CELL SURVIVAL; COLITIS; CONTROLLED STUDY; CYTOARCHITECTURE; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INTESTINE CRYPT; INTESTINE EPITHELIUM CELL; LARGE INTESTINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; WILD TYPE; WOUND HEALING;

EID: 79959935078     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.03.043     Document Type: Article

References (39)

1. D.K. Podolsky Inflammatory bowel disease N Engl J Med 347 2002 417 429 (Pubitemid 34851835)
2. E. Sancho, E. Batlle, and H. Clevers Signaling pathways in intestinal development and cancer Annu Rev Cell Dev Biol 20 2004 695 723 (Pubitemid 39488655)
3. W. de Lau, N. Barker, and H. Clevers WNT signaling in the normal intestine and colorectal cancer Front Biosci 12 2007 471 491 (Pubitemid 46852800)
4. A. Glinka, W. Wu, and H. Delius Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction Nature 391 1998 357 362 (Pubitemid 28093502)
5. P. Nava, S. Koch, and M.G. Laukoetter Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways Immunity 32 2010 392 402
6. D. Pinto, A. Gregorieff, and H. Begthel Canonical Wnt signals are essential for homeostasis of the intestinal epithelium Genes Dev 17 2003 1709 1713 (Pubitemid 36870334)
7. F. Kuhnert, C.R. Davis, and H.T. Wang Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1 Proc Natl Acad Sci U S A 101 2004 266 271 (Pubitemid 38084239)
8. B.T. MacDonald, M. Adamska, and M.H. Meisler Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6 Development 131 2004 2543 2552 (Pubitemid 38877888)
9. X.C. He, T. Yin, and J.C. Grindley PTEN-deficient intestinal stem cells initiate intestinal polyposis Nat Genet 39 2007 189 198 (Pubitemid 46184349)
10. T.L. Denning, Y.C. Wang, and S.R. Patel Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses Nat Immunol 8 2007 1086 1094 (Pubitemid 47423756)
11. B. Mao, W. Wu, and G. Davidson Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling Nature 417 2002 664 667 (Pubitemid 34614827)
12. D. Diarra, M. Stolina, and K. Polzer Dickkopf-1 is a master regulator of joint remodeling Nat Med 13 2007 156 163
13. S. Koch, C.T. Capaldo, and S. Samarin Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells Mol Biol Cell 20 2009 4816 4825
14. Y. Li, W. Lu, and T.D. King Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation PLoS One 5 2010 e11014
15. T. Weissmuller, E.L. Campbell, and P. Rosenberger PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases J Clin Invest 118 2008 3682 3692
16. H. Sheng, J. Shao, and C.M. Townsend Jr Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells Gut 52 2003 1472 1478 (Pubitemid 37176728)
17. F. Luo, D.G. Brooks, and H. Ye Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways Int J Exp Pathol 90 2009 558 574
18. J. Zhang, C.R. Owen, and M.A. Sanders The motogenic effects of cyclic mechanical strain on intestinal epithelial monolayer wound closure are matrix dependent Gastroenterology 131 2006 1179 1189 (Pubitemid 44498697)
19. S.H. Lee, L.L. Hu, and J. Gonzalez-Navajas ERK activation drives intestinal tumorigenesis in Apc(min/+) mice Nat Med 16 2010 665 670
20. R. Sancho, A.S. Nateri, and A.G. de Vinuesa JNK signalling modulates intestinal homeostasis and tumourigenesis in mice EMBO J 28 2009 1843 1854
21. S. Wirtz, C. Neufert, and B. Weigmann Chemically induced mouse models of intestinal inflammation Nat Protoc 2 2007 541 546 (Pubitemid 47040018)
22. A. Gregorieff, D. Pinto, and H. Begthel Expression pattern of Wnt signaling components in the adult intestine Gastroenterology 129 2005 626 638 (Pubitemid 41096648)
23. C.C. Tai, F.G. Sala, and H.R. Ford Wnt5a knock-out mouse as a new model of anorectal malformation J Surg Res 156 2009 278 282
24. H. Lickert, A. Kispert, and S. Kutsch Expression patterns of Wnt genes in mouse gut development Mech Dev 105 2001 181 184 (Pubitemid 32586771)
25. I.B. Renes, M. Verburg, and D.J. Van Nispen Epithelial proliferation, cell death, and gene expression in experimental colitis: alterations in carbonic anhydrase I, mucin MUC2, and trefoil factor 3 expression Int J Colorectal Dis 17 2002 317 326 (Pubitemid 36067766)
26. M.A. Forget, S. Turcotte, and D. Beauseigle The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types Br J Cancer 96 2007 646 653
27. J. Li, I. Sarosi, and R.C. Cattley Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia Bone 39 2006 754 766 (Pubitemid 44311706)
28. T. Ueland, K. Otterdal, and T. Lekva Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis Arterioscler Thromb Vasc Biol 29 2009 1228 1234
29. K.R. Hughes, F. Sablitzky, and Y.R. Mahida Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells Inflamm Bowel Dis 17 2011 213 220
30. D.M. Smadja, C. d'Audigier, and L.B. Weiswald The Wnt antagonist Dickkopf-1 increases endothelial progenitor cell angiogenic potential Arterioscler Thromb Vasc Biol 30 2010 2544 2552
31. A. Niida, T. Hiroko, and M. Kasai DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway Oncogene 23 2004 8520 8526 (Pubitemid 39540802)
32. S. Manicassamy, B. Reizis, and R. Ravindran Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine Science 329 2010 849 853
33. D.H. Scoville, T. Sato, and X.C. He Current view: intestinal stem cells and signaling Gastroenterology 134 2008 849 864 (Pubitemid 351312767)
34. D. Fang, D. Hawke, and Y. Zheng Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity J Biol Chem 282 2007 11221 11229 (Pubitemid 47100795)
35. G. Lee, T. Goretsky, and E. Managlia Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis Gastroenterology 139 2010 869 881
36. J.B. Brown, G. Lee, and E. Managlia Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis Gastroenterology 138 2010 595 605
37. B.T. MacDonald, M. Adamska, and M.H. Meisler Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6 Development 131 2004 2543 2552 (Pubitemid 38877888)
38. P. Nava, S. Koch, and M.G. Laukoetter Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways Immunity 32 2010 392 402
39. S. Koch, C.T. Capaldo, and S. Samarin Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells Mol Biol Cell 20 2009 4816 4825