Pulmonary vasoconstrictor influence of endothelin in exercising swine depends critically on phosphodiesterase 5 activity

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 306, Issue 5, 2014, Pages

  Zhou, Zhichao ^a,b   de Beer, Vincent J ^a,b   de Wijs Meijler, Daphne ^a,b,c   Bender, Shawn B ^d,e   Hoekstra, Maaike ^a,b   Harold Laughlin, M ^d   Duncker, Dirk J ^a,b   Merkus, Daphne ^a,b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^d UNIVERSITY OF MISSOURI   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Big ET; Exercise; PDE5 inhibition; Pulmonary vascular tone

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CYCLIC GMP; EMD 360527; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; TEZOSENTAN; UNCLASSIFIED DRUG; VASODILATOR AGENT; ENDOTHELIN; PYRIDINE DERIVATIVE; TETRAZOLE DERIVATIVE; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL PIG; FEMALE; IN VITRO STUDY; LUNG ARTERY; LUNG BLOOD VESSEL; LUNG CIRCULATION; LUNG VASCULAR RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY OCCLUSION; RECEPTOR BLOCKING; SYSTEMIC CIRCULATION; TREADMILL EXERCISE; VASODILATATION; ANIMAL; BIG ET; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ETA/ETB RECEPTOR BLOCKADE; EXERCISE; HUMAN; METABOLISM; PDE5 INHIBITION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SWINE; VASOCONSTRICTION;

BIG ET; ETA/ETB RECEPTOR BLOCKADE; EXERCISE; PDE5 INHIBITION; PULMONARY VASCULAR TONE;

ANIMALS; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DRUG SYNERGISM; ENDOTHELINS; FEMALE; HUMANS; MALE; PHOSPHODIESTERASE 5 INHIBITORS; PHYSICAL CONDITIONING, ANIMAL; PULMONARY CIRCULATION; PYRIDINES; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; SIGNAL TRANSDUCTION; SUS SCROFA; TETRAZOLES; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 84900541685     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00057.2013     Document Type: Article

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