Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 1, 2009, Pages

  Mouchaers, Koen T B ^a   Schalij, Ingrid ^a   Versteilen, Amanda M G ^a   Hadi, Awal M ^a   Van Nieuw Amerongen, Geerten P ^a   Van Hinsbergh, Victor W M ^a   Postmus, Pieter E ^a   Van Der Laarse, Willem J ^a   Vonk Noordegraaf, Anton ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bosentan; Chronic heart failure; Mitochondria; Oxidative capacity; Sildenafil

Indexed keywords

BOSENTAN; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYTOCHROME C OXIDASE; ENDOTHELIN RECEPTOR; MONOCROTALINE; PHOSPHODIESTERASE V; SILDENAFIL; SUCCINATE DEHYDROGENASE; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART CATHETERIZATION; HEART FUNCTION; HEART MITOCHONDRION; HEART MUSCLE FIBROSIS; HEART MUSCLE METABOLISM; HEART RIGHT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE CONTRACTILITY; HEART VENTRICLE PRESSURE; HISTOCHEMISTRY; LUNG VASCULAR RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PULMONARY HYPERTENSION; RAT; RECEPTOR BLOCKING;

ANIMALS; BODY WEIGHT; CAPILLARIES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DIFFUSION; FIBROSIS; HEMODYNAMICS; HYPERTENSION, PULMONARY; MALE; MITOCHONDRIA, HEART; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; MYOGLOBIN; ORGAN SIZE; OXYGEN CONSUMPTION; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PULMONARY ARTERY; PURINES; RATS; RATS, WISTAR; RECEPTORS, ENDOTHELIN; SULFONAMIDES; SULFONES;

EID: 67650069940     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00893.2008     Document Type: Article

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