Ambrisentan and tadalafil synergistically relax endothelin-induced contraction of rat pulmonary arteries

Hypertension

Volumn 59, Issue 3, 2012, Pages 705-711

  Liang, Faquan ^a   Yang, Suya ^a   Yao, Lina ^a   Belardinelli, Luiz ^a   Shryock, John ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

endothelin receptor antagonist; endothelin 1; phosphodiesterase inhibitor; pulmonary arterial hypertension; pulmonary artery

Indexed keywords

AMBRISENTAN; BOSENTAN; CYCLIC GMP; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; MACITENTAN; MYOSIN LIGHT CHAIN KINASE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; N(G) NITROARGININE METHYL ESTER; TADALAFIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY ARTERY OCCLUSION; RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; BLOTTING, WESTERN; CARBOLINES; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; ENDOTHELIN-1; HYPERTENSION, PULMONARY; MALE; PHENYLPROPIONATES; PULMONARY ARTERY; PYRIDAZINES; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION; VASODILATOR AGENTS;

EID: 84862776722     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.182261     Document Type: Article

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