Nitric oxide contributes to the regulation of vasomotor tone but does not modulate O2-consumption in exercising swine

Cardiovascular Research

Volumn 47, Issue 4, 2000, Pages 738-748

  Duncker, Dirk J ^a   Stubenitsky, René ^a   Tonino, Pim A L ^a   Verdouw, Pieter D ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Coronary circulation; Nitric oxide; Oxygen consumption; Pulmonary circulation; Vasoconstriction dilation

Indexed keywords

N(G) NITROARGININE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL TONE; CARDIOVASCULAR AUTOREGULATION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; EXERCISE; LUNG BLOOD FLOW; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SWINE; VASOMOTOR REFLEX;

ANIMALS; CORONARY CIRCULATION; DOGS; ENZYME INHIBITORS; EXERCISE; FEMALE; HUMANS; MALE; MUSCLE, SKELETAL; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROARGININE; OXYGEN CONSUMPTION; PULMONARY CIRCULATION; REGIONAL BLOOD FLOW; SPECIES SPECIFICITY; SWINE; VASCULAR RESISTANCE; VASOCONSTRICTOR AGENTS;

EID: 0033842548     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00143-7     Document Type: Article

References (40)

1. Parent R., al-Obaidi M., Lavallee M. Nitric oxide formation contributes to β-adrenergic dilation of resistance coronary vessels in conscious dogs. Circ. Res. 73:1993;241-251.
2. Smith T.P. Jr., Canty J.M. Jr. Modulation of coronary autoregulatory responses by nitric oxide. Evidence for flow-dependent resistance adjustments in conscious dogs. Circ. Res. 73:1993;232-240.
3. Altman J.D., Kinn J., Duncker D.J., Bache R.J. Effect of inhibition of nitric oxide formation on coronary blood flow during exercise in the dog. Cardiovasc. Res. 28:1994;119-124.
4. Bernstein R.D., Ochoa F.Y., Xu X., et al. Function and production of nitric oxide in the coronary circulation of the conscious dog during exercise. Circ. Res. 79:1996;840-848.
5. Lefroy D.C., Crake T., Uren N.G., Davies G.J., Maseri A. Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans. Circulation. 88:1993;43-54.
6. Quyyumi A.A., Dakak N., Andrews N.P., Gilligan D.M., Panza J.A., Cannon R.O. III. Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation. 92:1995;320-326.
7. Nishikawa Y., Kanki H., Ogawa S. Role of nitric oxide in coronary vasomotion during handgrip exercise. Am. Heart J. 134:1997;967-973.
8. Laughlin M.H., Korthuis R., Duncker D.J., Bache R.J. Regulation of blood flow to cardiac and skeletal muscle during exercise. Rowell L.B., Shepherd J.T. Regulation and integration of multiple systems during exercise. American physiological society handbook section 12. 1996;705-769 Oxford Press, New York.
9. Duncker D.J., Stubenitsky R., Verdouw P.D. Autonomic control of vasomotion in the porcine coronary circulation during treadmill exercise: evidence for feed-forward β-adrenergic control. Circ. Res. 82:1998;1312-1322.
10. Shen W., Xu X., Ochoa M., Zhao G., Wolin M.S., Hintze T.H. Role of nitric oxide in the regulation of oxygen consumption in conscious dogs. Circ. Res. 75:1994;1086-1095.
11. Stamler J.S., Loh E., Roddy M.A., Currie K.E., Creager M.A. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation. 89:1994;2035-2040.
12. G-nitro-arginine. Br. J. Pharmacol. 102:1991;565-566.
13. Sigmon D.H., Florentino-Pineda I., Van Dyke R.A., Beierwaltes W.H. Halothane impairs the hemodynamic influence of endothelium-derived nitric oxide. Anesthesiology. 82:1995;135-143.
14. Koizumi T., Gupta R., Banerjee M., Newman J.H. Changes in pulmonary vascular tone during exercise. Effects of nitric oxide (NO) synthase inhibition, L-arginine infusion, and NO inhalation. J. Clin. Invest. 94:1994;2275-2282.
15. Shen W., Lundborg M., Wang J., et al. Role of EDRF in the regulation of regional blood flow and vascular resistance at rest and during exercise in conscious dogs. J. Appl. Physiol. 77:1994;165-172.
16. ω-Nitro-L-arginine and pulmonary vascular pressure-flow relationship in conscious dogs. Am. J. Physiol. 262:1992;H1331-H1337.
17. Koller-Strametz J., Matulla B., Wolzt M., et al. Role of nitric oxide in exercise-induced vasodilation in man. Life Sci. 62:1998;1035-1042.
18. Kirkeboen K.A., Naess P.A., Offstad J., Ilebekk A. Effects of regional inhibition of nitric oxide synthesis in intact porcine hearts. Am. J. Physiol. 266:1994;H1516-H1527.
19. Stubenitsky R., Verdouw P.D., Duncker D.J. Autonomic control of cardiovascular performance and oxygen transport in awake swine at rest and during treadmill exercise. Cardiovasc. Res. 39:1998;459-474.
20. Saxena P.R., Verdouw P.D. Tissue blood flow and localization of arteriovenous anastomoses in pigs with microspheres of four different sizes. Pfluegers Arch. 403:1985;128-135.
21. Duncker D.J., Haitsma D.B., van der Geest I.E., et al. Systemic, pulmonary and coronary haemodynamic actions of the novel dopamine receptor agonist Z1046 in awake pigs at rest and during treadmill exercise. Br. J. Pharmacol. 120:1997;1101-1113.
22. Kitakaze M., Node K., Komamura K., Minamino T., Kosaka H., Kuzuya T., Hori M. Intracoronary administration of adenosine triphosphate increases coronary flow and attenuates the severity of myocardial ischemic injury in dogs. Cardiovasc. Drugs Ther. 13:1999;407-414.
23. O'Leary D.S., Dunlap R.C., Glover K.W. Role of endothelium-derived relaxing factor in hindlimb reactive and active hyperemia in conscious dogs. Am. J. Physiol. 266:1994;R1213-R1219.
24. Vallance P., Collier J., Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. ii:1989;997-1000.
25. Wilson J.R., Kapoor S. Contribution of endothelium-derived relaxing factor to exercise-induced vasodilation in humans. J. Appl. Physiol. 75:1993;2740-2744.
26. Radegran G., Saltin B. Nitric oxide in the regulation of vasomotor tone in human skeletal muscle. Am. J. Physiol. 276:1999;H1951-H1960.
27. Endo T., Imaizumi T., Tagawa T., Shiramoto M., Ando S., Takeshita A. Role of nitric oxide in exercise-induced vasodilation of the forearm. Circulation. 90:1994;2886-2890.
28. Brock R.W., Tschakovsky M.E., Shoemaker J.K., Halliwill J.R., Joyner M.J., Hughson R.L. Effects of acetylcholine and nitric oxide on forearm blood flow at rest and a single muscle contraction. J. Appl. Physiol. 85:1998;2249-2254.
29. Hirai T., Visneski M.D., Kearns K.J., Zelis R., Musch T.I. Effects of NO synthase inhibition on the muscular blood flow response to treadmill exercise in rats. J. Appl. Physiol. 77:1994;1288-1293.
30. Hales J.R.S., Molyneux G.S. Control of cutaneous arteriovenous anastomoses. Vanhoutte P.M. Vasodilatation: vascular smooth muscle, peptides, autonomic nerves and endothelium. 1988;321-332 Raven Press, New York.
31. Baile E.M., Nelems J.M., Schulzer M., Pare P.D. Measurement of regional bronchial arterial blood flow and bronchovascular resistance in dogs. J. Appl. Physiol. 53:1982;1044-1049.
32. Barnes P.J., Liu S.F. Regulation of pulmonary vascular tone. Pharmacol. Rev. 47:1995;87-131.
33. Oka M., Hasunuma K., Webb S.A., Stelzner T.J., Rodman D.M., McMurtry I.F. EDRF suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs. Am. J. Physiol. 264:1993;L587-L597.
34. Wolin M.S., Xie Y.W., Hintze T.H. Nitric oxide as a regulator of tissue oxygen consumption. Curr. Opin. Nephrol. Hypertens. 8:1999;97-103.
35. 2 uptake after inhibition of EDRF/NO synthesis. J. Appl. Physiol. 76:1994;1166-1171.
36. Crystal G.J., Zhou X., Halim A.A., Alam S., El-Orbany M., Salem M.R. Nitric oxide does not modulate whole body oxygen consumption in anesthetized dogs. J. Appl. Physiol. 86:1999;1944-1949.
37. Sadoff J.D., Scholz P.M., Weiss H.R. Endogenous basal nitric oxide production does not control myocardial oxygen consumption or function. Proc. Soc. Exp. Biol. Med. 211:1996;332-338.
38. Crystal G.J., Gurevicius J. Nitric oxide does not modulate myocardial contractility acutely in in situ canine hearts. Am. J. Physiol. 270:1996;H1568-H1576.
39. Sherman A.J., Davis C.A. III, Klocke F.J., et al. Blockade of nitric oxide synthesis reduces myocardial oxygen consumption in vivo. Circulation. 95:1997;1328-1334.
40. Wang J., Seyedi N., Xu X.B., Wolin M.S., Hintze T.H. Defective endothelium-mediated control of coronary circulation in conscious dogs after heart failure. Am. J. Physiol. 266:1994;H670-H680.