Autonomic control of cardiovascular performance and whole body O2 delivery and utilization in swine during treadmill exercise

Cardiovascular Research

Volumn 39, Issue 2, 1998, Pages 459-474

  Stubenitsky, René ^a   Verdouw, Pieter D ^a   Duncker, Dirk J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Autonomic nervous system; Exercise; O2 consumption; O2 extraction; Pulmonary circulation; Swine; Systemic circulation

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; ATROPINE; BETA ADRENERGIC RECEPTOR; MUSCARINIC RECEPTOR; OXYGEN; PHENTOLAMINE; PROPRANOLOL;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; AORTA PRESSURE; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BETA ADRENERGIC RECEPTOR BLOCKING; CARDIOVASCULAR PERFORMANCE; CHOLINERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; FEMALE; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; LUNG CIRCULATION; MALE; NONHUMAN; OXYGEN CONSUMPTION; PARASYMPATHETIC INNERVATION; PRIORITY JOURNAL; SWINE; SYMPATHETIC TONE; SYSTEMIC CIRCULATION; SYSTEMIC VASCULAR RESISTANCE; TREADMILL EXERCISE;

EID: 0032145287     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(98)00102-3     Document Type: Article

References (66)

1. [1] Laughlin MH, Korthuis R, Duncker DJ, Bache RJ, Regulation of blood flow to cardiac and skeletal muscle during exercise. In: Rowell LB, Shepherd JT, editors. Handbook of physiology (Section 12); exercise: Regulation and integration of multiple systems. New York: Am Physiol Soc/Oxford University Press, 1996:705-769.
2. [2] Hastings AB, White FC, Sanders TM, Bloor CM. Comparative physiological responses to exercise stress. J Appl Physiol 1982;52:1077-1083.
3. [3] Sanders M, White F, Bloor C. Cardiovascular responses of dogs and pigs exposed to similar physiological stress. Comp Biochem Physiol 1977;58:365-370.
4. [4] Scheffer MG, Verdouw PD. Decreased incidence of ventricular fibrillation after an acute coronary artery ligation in exercised pigs. Basic Res Cardiol 1983;78:298-309.
5. 2-adrenergic receptors in the regulation of myocardial performance during exercise in conscious dogs. Circ Res 1984;54:683-693.
6. [6] Duncker DJ, Saxena PR, Verdouw PD. Systemic haemodynamic and beta-adrenoceptor antagonistic effects of bisoprolol in conscious pigs: a comparison with propranolol. Arch Int Pharmacodyn Ther 1987;290:54-63.
7. [7] Duncker DJ, Saxena PR, Verdouw PD. Systemic haemodynamics of dihydropyridine derivatives in conscious pigs with or without propranolol. Eur J Pharmacol 1988;156:401-409.
8. [8] Duncker DJ, Haitsma DB, Van der Geest IEJ, et al. Systemic, pulmonary and coronary haemodynamic actions of the novel dopamine receptor agonist Z1046 in awake pigs at rest and during treadmill exercise. Br J Pharmacol 1997;120:1101-1113.
9. 2+-sensitizer EMD 57033 in chronically instrumented pigs at rest and during treadmill exercise. Br J Pharmacol 1997;122:1257-1270.
10. [10] Verdouw PD, Duncker DJ, Saxena PR. Poor vasoconstrictor response to adrenergic stimulation in the arteriovenous anastomoses present in the carotid vascular bed of young yorkshire pigs. Arch Int Pharmacodyn Ther 1984;272:56-70.
11. [11] Bom AH, Duncker DJ, Saxena PR, Verdouw PD. 5-Hydroxytryptamine-induced tachycardia in the pig: mediation by a new type of 5-hydroxytryptamine receptor. Br J Pharmacol 1988;93:663-671.
12. [12] White FC, Sanders M, Bloor CM. Coronary reserve at maximal heart rate in the exercising swine. Cardiac Rehab 1981;1:31-39.
13. [13] Sanders M, White FC, Peterson TM, Bloor CM. Myocardial blood flow distribution in miniature pigs during exercise. Basic Res Cardiol 1977;72:326-331.
14. [14] Breisch EA, White FC, Nimmo LE, McKirnan MD, Bloor CM. Exercise-induced cardiac hypertrophy: a correlation of blood flow and microvasculature. J Appl Physiol 1986;60:1259-1267.
15. [15] Ciccone CD, Lakas CS, Zambraski EJ. Oxygen consumption in treadmill-exercised Yucatan miniature swine. Med Sci Sports Exerc 1982; 14:467-470.
16. [16] Laughlin MH, Klabunde RE, Delp MD, Armstrong RB. Effects of dipyridamole on muscle blood flow in exercising miniature swine. Am J Physiol 1989;257:H1507-H1515.
17. [17] Cerretelli P, Prampero PE di. Gas exchange in exercise. In: Farhi LE, Tenney SM, editors. Handbook of physiology (Section 3), The respiratory system (vol 4), Gas exchange. Bethesda: Am Physiol Soc, 1987:297-340.
18. [18] Barger AC, Richards V, Metcalfe J, Gunther B. Regulations of the circulation during exercise: cardiac output and metabolic adjustment in the normal dog. Am J Physiol 1956;184:613-623.
19. [19] Cerretelli P, Püper J, Mangili F, Cuttica F, Ricci B. Circulation in exercising dogs. J Appl Physiol 1964;19:29-32.
20. [20] Young DR, Mosher R, Erve P, Spector H. Energy metabolism and gas exchange during treadmill running dogs. J Appl Physiol 1959;14:834-838.
21. [21] Parks CM, Manohar M. Transmural coronary vasodilator reserve and flow distribution during severe exercise in ponies. J Appl Physiol 1983;54:1641-1652.
22. 2max and oxidative capacity in muscles of standardbred horses. J Appl Physiol 1992;73:2274-2282.
23. [23] White FC, Roth DM, Bloor CM. The pig as a model for myocardial ischemia and exercise. Lab Anim Sci 1986;36:351-356.
24. [24] Cohen MV Training in dogs with normal coronary arteries: lack of effect on collateral development. Cardiovasc Res 1990;24:121-128.
25. [25] Von Restorff W, Hofling B, Holtz J, Bassenge E. Effect of increased blood fluidity through hemodilution on coronary circulation at rest and during exercise in dogs. Pflug Arch Eur J Physiol 1975;357:15-24.
26. [26] Manohar M. Transmural coronary vasodilator reserve and flow distribution during maximal exercise in normal and splenectomized ponies. J Physiol (Lond) 1987;387:425-440.
27. [27] Armstrong RB, Delp MD, Goljan EF, Laughlin MH. Distribution of blood flow in muscles of miniature swine during exercise. J Appl Physiol 1987;62:1285-1298.
28. [28] Khouri EM, Gregg DE, Rayford CR. Effect of exercise on cardiac output, left coronary flow and myocardial metabolism in the unanesthetized dog. Circ Res 1965;17:427-437.
29. [29] Von Restorff W, Holtz J, Bassenge E. Exercise induced augmentation of myocardial oxygen extraction in spite of normal coronary dilatory capacity in dogs. Pflug Arch Eur J Physiol 1977;372:181-185.
30. [30] Vatner SF, Higgins CB, Millard RW, Franklin D. Role of the spleen in the peripheral vascular response to severe exercise in untethered dogs. Cardiovasc Res 1974;8:276-282.
31. [31] Persson SGB, Lydin G. Circulatory effects of splenectomy in the horse. Zentralbl Veterinaermed Reihe A 1973;20:521-530.
32. [32] Jones JH, Longworth KE, Lindholm A, et al. Oxygen transport during exercise in large mammals. I. Adaptive variation in oxygen demand. J Appl Physiol 1989;67:862-870.
33. [33] Mundie TG, Januszkiewicz AJ, Ripple GR. Effects of epinephrine, phenoxybenzamine, and propranolol on maximal exercise in sheep. Lab Anim Sci 1992;42:486-490.
34. [34] Steinhardt M, Petzold K, Lyhs L. Blutspeicherfunktion der milz beim hausschwein. I. Einfluss von adrenalin und körperlicher arbeit auf den hämatokritwert und hämoglobingehalt. Arch Exp Veterinaermed 1970;24:817-826.
35. [35] Rowell LB. Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev 1974;54:75-159.
36. [36] Harrison MH. Effects of thermal stress and exercise on blood volume in humans. Physiol Rev 1985;65:149-209.
37. [37] Shen W, Xu X, Ochoa M, et al. Role of nitric oxide in the regulation of oxygen consumption in conscious dogs. Circ Res 1994;75:1086-1095.
38. [38] Sanders M, White FC, Peterson TM, Bloor CM. Characteristics of coronary blood flow and transmural distribution in miniature pigs. Am J Physiol 1978;235:H601-H609.
39. [39] Engelhardt Wv. Cardiovascular effects of exercise and training in horses. Adv Vet Sci Comp Med 1977;7:173-205.
40. [40] Vatner SF, Franklin D, Higgins CB, Patrick T, Braunwald E. Left ventricular response to severe exertion in untethered dogs. J Clin Invest 1972;51:3052-3060.
41. [41] Janicki JS, Sheriff DD, Robotham JL, Wise RA. Cardiac output during exercise: contributions of the cardiac, circulatory, and respiratory systems. In: Rowell LB, Shepherd JT, editors. Handbook of physiology (Section 12); Exercise: Regulation and integration of multiple systems. New York: Am Physiol Soc/Oxford University Press, 1996:649-704.
42. [42] Reeves JT, Taylor AE. Pulmonary hemodynamics and fluid exchange in the lungs during exercise. In: Rowell LB, Shephard JT, editors. Handbook of physiology (Section 12); Exercise: Regulation and integration of multiple systems. New York: Am Physiol Soc/ Oxford University Press, 1996:585-613.
43. [43] Kane DW, Tesauro T, Newman JH. Adrenergic modulation of the pulmonary circulation during strenuous exercise in the sheep. Am Rev Respir Dis 1993;147:1233-1238.
44. [44] Pitt B. Effect of β-adrenergic receptor blockade on coronary hemodynamics in the resting unanaesthetized dog. Cardiovasc Res 1970;4:89-92.
45. [45] Bassenge E, Kucharczyk M, Holtz J, Stolan D. Treadmill exercise in dogs under β-adrenergic blockade: adaptation of coronary and systemic hemodynamics. Pflug Arch Eur J Physiol 1972;332:40-55.
46. [46] McHodgson JB, Cohen MD, Szentpetery S, Thames MD. Effects of regional α-and β-blockade on resting and hyperemic coronary blood flow in conscious, unstressed humans. Circulation 1989;79:797-809.
47. [47] Epstein SE, Robinson BI, Kahler RL, Braunwald E. Effect of β-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man. J Clin Invest 1965;44:1745.
48. [48] Tesch PA. Exercise performance and beta-blockade. Sports Med 1985;2:389-412.
49. [49] Hyman AL, Nandiwada P, Knight DS, Kadowitz PJ. Pulmonary vasodilator responses to catecholamines and sympathetic nerve stimulation in the cat. Evidence that vascular beta2 and adreno-receptors are innervated. Circ Res 1981;48:407-415.
50. [50] Murray PA, Lodato RF, Michael JR. Neural antagonists modulate pulmonary vascular pressure-flow plots in conscious dogs. J Appl Physiol 1986;60:1900-1907.
51. [51] Kane DW, Tesauro T, Koizumi T, Gupta R, Newman JH. Exercise induced pulmonary vasoconstriction during combined blockade of nitric oxide synthase and beta-adrenergic receptors. J Clin Invest 1994;93:677-683.
52. [52] Langer SZ. Presynaptic receptors and their role in the regulation of transmitter release. Br J Pharmacol 1977;60:481-497.
53. [53] Vatner SF, Pagani MS. Cardiovascular adjustments to exercise: hemodynamics and mechanisms. Prog Cardiovasc Dis 1976;19:91-108.
54. [54] Cocks TM, Angus JA. Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature 1983;305:627-630.
55. 2 reduce requirement for CBF in conscious dogs. Am J Physiol 1995;269:H491-H503.
56. [56] Heyndrickx GR, Muylaert P, Pannier JL. α-Adrenergic control of oxygen delivery to myocardium during exercise in conscious dogs. Am J Physiol 1982;242:H805-H809.
57. 1-adrenergic blockade on coronary blood flow during exercise. Circ Res 1987;61(Suppl II):II-36-II-41.
58. [58] Barnes PJ, Liu SF. Regulation of pulmonary vascular tone. Pharmacol Rev 1995;47:87-131.
59. [59] Robinson BF, Epstein SE, Beiser GD, Braunwald E. Control of heart rate by the autonomie nervous system: studies in man on the interrelation between baroreceptor mechanisms and exercise. Circ Res 1966;19:400-411.
60. 2-receptors in the unanaesthetized rabbit. Eur J Pharmacol 1977;45:45-53.
61. [61] Gho BCG, Schoemaker RG, van den Doel M, Duncker DJ, Verdouw PD. Myocardial protection by transient ischaemia in non-cardiac tissue. Circulation 1996;94:2193-2200.
62. [62] Koch-Weser J, Blinks JR. Influence of the interval between beats on myocardial contractility. Pharmacol Rev 1963;15:610-652.
63. [63] Ekblom B, Goldbarg AN, Kilbom A, Åstrand P-O. Effects of atropine and propranolol on the oxygen transport system during exercise in man. Scand J Clin Lab Invest 1972;30:35-42.
64. [64] Keck EWO, Allwood MJ, Marshall RJ, Shepherd JT. Effects of catecholamines and atropine on cardiovascular response to exercise in the dog. Circ Res 1961;9:566-570.
65. [65] Atkins JM, Horwitz LD. Cardiac autonomie blockade in exercising dogs. J Appl Physiol 1977;42:878-883.
66. [66] Westenskow DR, Huffaker JK, Stanley TH. The effect of dopamine, atropine, phenylephrine and cardiac pacing on oxygen consumption during fentanyl-nitrous oxide anaesthesia in the dog. Can Anaesth Soc J 1981;28:121-124.