Nuclear factor κb downregulates the transient outward potassium current Ito,f through control of KChIP2 expression

Circulation Research

Volumn 108, Issue 5, 2011, Pages 537-543

  Panama, Brian K ^a   Latour Villamil, Desiree ^a   Farman, Gerrie P ^a   Zhao, Dongling ^a   Bolz, Steffen Sebastian ^a   Kirshenbaum, Lorrie A ^b   Backx, Peter H ^a,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c Fitzgerald Bldg   (Canada)

Author keywords

gene expression; hypertrophy; Ito; potassium channel

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CALCINEURIN; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KV CHANNEL INTERACTING PROTEIN; MESSENGER RNA; PHENYLEPHRINE; POTASSIUM CHANNEL; PROPRANOLOL; PROTEIN KCHIP 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; KCNIP2 PROTEIN, RAT; SHAL POTASSIUM CHANNEL;

ALPHA ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HEART VENTRICLE HYPERTROPHY; MUSCLE CELL; MUTATION; NEWBORN; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; CELL CULTURE; DISEASE MODEL; DRUG EFFECT; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HYPERTROPHY, LEFT VENTRICULAR; KV CHANNEL-INTERACTING PROTEINS; MYOCYTES, CARDIAC; NF-KAPPA B; PHENYLEPHRINE; POTASSIUM CHANNELS; PROPRANOLOL; RATS; RATS, SPRAGUE-DAWLEY; SHAL POTASSIUM CHANNELS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79952749887     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.229112     Document Type: Article

References (32)

1. Niwa N, Nerbonne JM. Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation. J Mol Cell Cardiol. 2010;48:12-25.
2. Sah R, Ramirez RJ, Oudit GY, Gidrewicz D, Trivieri MG, Zobel C, Backx PH. Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol. 2003;546:5-18. (Pubitemid 36104968)
3. Kassiri Z, Zobel C, Nguyen TT, Molkentin JD, Backx PH. Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes. Circ Res. 2002;90:578-585. (Pubitemid 34640908)
4. Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, McKinnon D. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol. 2001;533:119-125. (Pubitemid 32499364)
5. Guo W, Li H, Aimond F, Johns DC, Rhodes KJ, Trimmer JS, Nerbonne JM. Role of heteromultimers in the generation of myocardial transient outward Kcurrents. Circ Res. 2002;90:586-593. (Pubitemid 34640909)
6. Zicha S, Xiao L, Stafford S, Cha TJ, Han W, Varro A, Nattel S. Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts. J Physiol. 2004;561: 735-748. (Pubitemid 40074931)
7. Delpon E, Cordeiro JM, Nunez L, Thomsen PE, Guerchicoff A, Pollevick GD, Wu Y, Kanters JK, Larsen CT, Burashnikov E, Christiansen M, Antzelevitch C. Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome. Circ Arrhythm Electrophysiol. 2008; 1:209-218.
8. Rossow CF, Minami E, Chase EG, Murry CE, Santana LF. NFATc3- induced reductions in voltage-gated Kcurrents after myocardial infarction. Circ Res. 2004;94:1340-1350. (Pubitemid 38724480)
9. Gong N, Bodi I, Zobel C, Schwartz A, Molkentin JD, Backx PH. Calcineurin increases cardiac transient outward Kcurrents via transcriptional up-regulation of Kv4.2 channel subunits. J Biol Chem. 2006;281: 38498-38506. (Pubitemid 46041974)
10. Smeets PJ, Teunissen BE, Planavila A, de Vogel-van den Bosch H, Willemsen PH, van der Vusse GJ, van Bilsen M. Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARalpha and PPARdelta. J Biol Chem. 2008;283:29109-29118.
11. Wong SC, Fukuchi M, Melnyk P, Rodger I, Giaid A. Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure. Circulation. 1998;98: 100-103. (Pubitemid 28317888)
12. Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, Lin A. Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci USA. 2001;98: 6668-6673. (Pubitemid 32538274)
13. Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Matsumura Y, Ueno H, Tada M, Hori M. Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2002;34:233-240. (Pubitemid 35222832)
14. Gupta S, Young D, Maitra RK, Gupta A, Popovic ZB, Yong SL, Mahajan A, Wang Q, Sen S. Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB. J Mol Biol. 2008;375:637-649.
15. Gupta S, Young D, Sen S. Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2005;289: H20-H29. (Pubitemid 40934078)
16. Jia Y, Takimoto K. Mitogen-activated protein kinases control cardiac KChIP2 gene expression. Circ Res. 2006;98:386-393.
17. Wagner J, Endoh M, Reinhardt D. Stimulation by phenylephrine of adrenergic alpha-and beta-receptors in the isolated perfused rabbit heart. Naunyn Schmiedebergs Arch Pharmacol. 1974;282:307-310.
18. Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci USA. 2007;104:16657-16662. (Pubitemid 350211072)
19. Mustapha S, Kirshner A, De Moissac D, Kirshenbaum LA. A direct requirement of nuclear factor-kappa B for suppression of apoptosis in ventricular myocytes. Am J Physiol Heart Circ Physiol. 2000;279: H939-H945.
20. Regula KM, Baetz D, Kirshenbaum LA. Nuclear factor-kappaB represses hypoxia-induced mitochondrial defects and cell death of ventricular myocytes. Circulation. 2004;110:3795-3802. (Pubitemid 40023978)
21. Lai MM, Burnett PE, Wolosker H, Blackshaw S, Snyder SH. Cain, a novel physiologic protein inhibitor of calcineurin. J Biol Chem. 1998; 273:18325-18331. (Pubitemid 28334757)
22. Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyêñ-Trân VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, Chien KR. A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell. 2001;107:801-813. (Pubitemid 34033672)
23. Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell. 2005;123:347-358. (Pubitemid 41457222)
24. Kaprielian R, Sah R, Nguyen T, Wickenden AD, Backx PH. Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K currents, and [Ca(2)](i) transients. Am J Physiol Heart Circ Physiol. 2002;283:H1157-H1168.
25. Jin H, Hadri L, Palomeque J, Morel C, Karakikes I, Kaprielian R, Hajjar R, Lebeche D. KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling. J Mol Cell Cardiol. 2010;48: 1169-1179.
26. Schrader LA, Birnbaum SG, Nadin BM, Ren Y, Bui D, Anderson AE, Sweatt JD. ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. Am J Physiol Cell Physiol. 2006;290:C852-C861.
27. Azzi M, Charest PG, Angers S, Rousseau G, Kohout T, Bouvier M, Pineyro G. Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci USA. 2003;100:11406-11411. (Pubitemid 37205948)
28. Janssen-Heininger YM, Poynter ME, Baeuerle PA. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med. 2000;28:1317-1327. (Pubitemid 30621476)
29. Wakisaka Y, Niwano S, Niwano H, Saito J, Yoshida T, Hirasawa S, Kawada H, Izumi T. Structural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure. Cardiovasc Res. 2004; 63:689-699. (Pubitemid 39078683)
30. Radicke S, Cotella D, Graf EM, Banse U, Jost N, Varró A, Tseng GN, Ravens U, Wettwer E. Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts. Cardiovasc Res. 2006;71:695-703. (Pubitemid 44848011)
31. Soltysinska E, Olesen SP, Christ T, Wettwer E, Varro A, Grunnet M, Jespersen T. Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts. Pflugers Arch. 2009; 459:11-23.
32. Gupta S, Sen S. Role of the NF-kappaB signaling cascade and NF-kappaB-targeted genes in failing human hearts. J Mol Med. 2005;83:993-1004. (Pubitemid 41745758)