Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner

Journal of Infectious Diseases

Volumn 209, Issue 12, 2014, Pages 1989-1999

  Doerflinger, Sylvie Y ^a,b   Throop, Andrea L ^b   Herbst Kralovetz, Melissa M ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

antimicrobial peptides; Atopobium vaginae; barrier function; epithelial cell; female reproductive tract; innate immunity; Lactobacillus spp.; mucin; Prevotella bivia; sexually transmitted infection; toll like receptor; vagina; vaginal microbiota and bacterial vaginosis

Indexed keywords

DEFENSIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MUCIN; PEPTIDE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ACTINOBACILLUS INFECTION; ARTICLE; ATOPOBIUM VAGINAE; BACTERIAL COLONIZATION; CCL20 GENE; CELL ADHESION; CELL AGGREGATION; CELL SURFACE; CYTOTOXICITY; EPITHELIUM CELL; GENE; GENE EXPRESSION; HBD 2 GENE; HOST CELL; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; INNATE IMMUNITY; LACTOBACILLUS; LACTOBACILLUS CRISPATUS; LACTOBACILLUS INERS; MICROBIOME; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANISMAL INTERACTION; PREVALENCE; PREVOTELLA BIVIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; UPREGULATION; VAGINA EPITHELIUM; VAGINA FLORA; VAGINITIS;

ANTIMICROBIAL PEPTIDES; ATOPOBIUM VAGINAE; BARRIER FUNCTION; EPITHELIAL CELL; FEMALE REPRODUCTIVE TRACT; INNATE IMMUNITY; LACTOBACILLUS SPP.; MUCIN; PREVOTELLA BIVIA; SEXUALLY TRANSMITTED INFECTION; TOLL-LIKE RECEPTOR; VAGINA; VAGINAL MICROBIOTA AND BACTERIAL VAGINOSIS;

ACTINOBACTERIA; ANTIMICROBIAL CATIONIC PEPTIDES; EPITHELIAL CELLS; EPITHELIUM; FEMALE; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; LACTOBACILLUS; MICROBIOTA; MUCINS; PREVOTELLA; SEXUALLY TRANSMITTED DISEASES; SPECIES SPECIFICITY; VAGINA; VAGINOSIS, BACTERIAL;

EID: 84900525927     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu004     Document Type: Article

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