Hsp27 suppresses the Cu2+-induced amyloidogenicity, redox activity, and cytotoxicity of α-synuclein by metal ion stripping

Free Radical Biology and Medicine

Volumn 72, Issue , 2014, Pages 176-190

  Asthana, Abhishek ^a   Bollapalli, Madhuri ^a   Tangirala, Ramakrishna ^a   Bakthisaran, Raman ^a   Mohan Rao, Ch ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Amyloid fibril; Free radicals; Hsp27; Reactive oxygen species; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID; AMYLOID BETA PROTEIN[1-40]; AMYLOID PROTEIN; ASCORBIC ACID; CUPRIC ION; HEAT SHOCK PROTEIN 27; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; AMYLOID BETA PROTEIN; COPPER;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; FLUORESCENCE SPECTROSCOPY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; METAL BINDING; MITOCHONDRION; NEURAL STEM CELL; NEUROBLASTOMA CELL; NONHUMAN; OXIDATION REDUCTION REACTION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN SYNTHESIS; STEADY STATE; UPREGULATION; CALORIMETRY; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; GENETIC TRANSFECTION; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

ALPHA-SYNUCLEIN; AMYLOID BETA-PEPTIDES; BLOTTING, WESTERN; CALORIMETRY; CELL LINE, TUMOR; COPPER; FLOW CYTOMETRY; HSP27 HEAT-SHOCK PROTEINS; HUMANS; MICROSCOPY, CONFOCAL; NEURONS; OXIDATION-REDUCTION; OXIDATIVE STRESS; TRANSFECTION;

EID: 84900499674     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.04.012     Document Type: Article

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