Structural and mechanistic implications of metal binding in the small heat-shock protein αB-crystallin

Journal of Biological Chemistry

Volumn 287, Issue 2, 2012, Pages 1128-1138

  Mainz, Andi ^a,b   Bardiaux, Benjamin ^a   Kuppler, Frank ^c   Multhaup, Gerd ^c   Felli, Isabella C ^d   Pierattelli, Roberta ^d   Reif, Bernd ^a,b,e  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d UNIVERSITY OF FLORENCE   (Italy)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BUILDING BLOCKES; CELLULAR STRESS; CHAPERONE ACTIVITY; CHAPERONE FUNCTIONS; CRYSTALLIN; DIMER INTERFACE; HIGHER ORDER; INTERMOLECULAR ARRANGEMENTS; IRREVERSIBLE AGGREGATION; LOOP RESIDUES; METAL BINDING; MISFOLDED PROTEINS; MULTIMERS; N-TERMINALS; PICOMOLAR BINDING; SALT BRIDGES; SMALL HEAT SHOCK PROTEINS; STRUCTURAL INSIGHTS; STRUCTURAL REORGANIZATION;

BINDING ENERGY; DIMERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

BINDING SITES;

ALPHA CRYSTALLIN; ARGININE; ASPARTIC ACID; BETA CRYSTALLIN; BETA LEVO CRYSTALLIN; CHAPERONE; COPPER ION; CRYSTALLIN; DIMER; HEAT SHOCK PROTEIN 20; HEAT SHOCK PROTEIN 27; HISTIDINE; OLIGOMER; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOPHYSICS; CONTROLLED STUDY; ENZYME ACTIVITY; HYDRODYNAMICS; METAL BINDING; METAZOON; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; REACTION ANALYSIS; STOICHIOMETRY;

ALPHA-CRYSTALLIN B CHAIN; BINDING SITES; CATIONS, DIVALENT; COPPER; HSP20 HEAT-SHOCK PROTEINS; HSP27 HEAT-SHOCK PROTEINS; HUMANS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP;

METAZOA;

EID: 84855478926     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.309047     Document Type: Article

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