메뉴 건너뛰기




Volumn 74, Issue 5, 2014, Pages 521-533

Omalizumab for severe asthma: Efficacy beyond the atopic patient?

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; IMMUNOGLOBULIN E; OMALIZUMAB; ANTIASTHMATIC AGENT; ANTIIDIOTYPIC ANTIBODY; MONOCLONAL ANTIBODY;

EID: 84900432516     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-014-0203-y     Document Type: Review
Times cited : (36)

References (102)
  • 1
    • 80355148549 scopus 로고    scopus 로고
    • Unconventional treatment options in severe asthma: An overivew
    • 22202222
    • Banh HL. Unconventional treatment options in severe asthma: an overivew. J Pharm Pharm Sci. 2011;14(3):387-99.
    • (2011) J Pharm Pharm Sci , vol.14 , Issue.3 , pp. 387-399
    • Banh, H.L.1
  • 2
    • 74849094691 scopus 로고    scopus 로고
    • Phenotypic differences between pediatric and adult asthma
    • 20008882
    • Bush A, Menzies-Gow A. Phenotypic differences between pediatric and adult asthma. Proc Am Thorac Soc. 2009;6(8):712-9.
    • (2009) Proc Am Thorac Soc , vol.6 , Issue.8 , pp. 712-719
    • Bush, A.1    Menzies-Gow, A.2
  • 3
    • 33747750597 scopus 로고    scopus 로고
    • The mechanisms, diagnosis, and management of severe asthma in adults
    • 16935689
    • Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet. 2006;368(9537):780-93.
    • (2006) Lancet , vol.368 , Issue.9537 , pp. 780-793
    • Holgate, S.T.1    Polosa, R.2
  • 4
    • 33644751216 scopus 로고    scopus 로고
    • Severe asthma: An overview
    • Mar quiz 495
    • Moore WC, Peters SP. Severe asthma: an overview. J Allergy Clin Immunol. 2006 Mar;117(3):487-94; quiz 495.
    • (2006) J Allergy Clin Immunol. , vol.117 , Issue.3 , pp. 487-494
    • Moore, W.C.1    Peters, S.P.2
  • 6
    • 0026591050 scopus 로고
    • National Heart, Lung, and Blood Institute, National Institutes of Health. International consensus report on diagnosis and treatment of asthma. Publication no. 92-3091, March 1992
    • National Heart, Lung, and Blood Institute, National Institutes of Health. International consensus report on diagnosis and treatment of asthma. Publication no. 92-3091, March 1992. Eur Respir J. 1992;5(5):601-41.
    • (1992) Eur Respir J. , vol.5 , Issue.5 , pp. 601-641
  • 7
    • 84993706094 scopus 로고    scopus 로고
    • Recommendation for optimal management of severe refractory asthma
    • 3047913 21437039
    • Morjaria JB, Polosa R. Recommendation for optimal management of severe refractory asthma. J Asthma Allergy. 2010;3:43-56.
    • (2010) J Asthma Allergy , vol.3 , pp. 43-56
    • Morjaria, J.B.1    Polosa, R.2
  • 8
    • 84875812821 scopus 로고    scopus 로고
    • Ultra-LAMA, ultra-LABA, ultra-inhaled steroids? the future has landed
    • 23415574
    • Domingo C. Ultra-LAMA, ultra-LABA, ultra-inhaled steroids? The future has landed. Arch Bronconeumol. 2013;49(4):131-4.
    • (2013) Arch Bronconeumol , vol.49 , Issue.4 , pp. 131-134
    • Domingo, C.1
  • 9
    • 84900430754 scopus 로고    scopus 로고
    • Federal Register, Food and Drug Administration. Biological products: allergenic extracts: implementation of efficacy review. Docket no. 81 N-0096 ed; 1985. p. CRF Parts 600, 10 and 80
    • Federal Register, Food and Drug Administration. Biological products: allergenic extracts: implementation of efficacy review. Docket no. 81 N-0096 ed; 1985. p. CRF Parts 600, 10 and 80.
  • 10
    • 0030920879 scopus 로고    scopus 로고
    • The use of standardized allergen extracts
    • American Academy of Allergy, Asthma and Immunology (AAAAI)
    • American Academy of Allergy, Asthma and Immunology (AAAAI). The use of standardized allergen extracts. J Allergy Clin Immunol. 1997;99(5):583-6.
    • (1997) J Allergy Clin Immunol , vol.99 , Issue.5 , pp. 583-586
  • 11
    • 33748301972 scopus 로고    scopus 로고
    • Specific immunotherapy: An optimistic future
    • 16942561
    • Bousquet J, Demoly P. Specific immunotherapy: an optimistic future. Allergy. 2006;61(10):1155-8.
    • (2006) Allergy , vol.61 , Issue.10 , pp. 1155-1158
    • Bousquet, J.1    Demoly, P.2
  • 12
    • 44249110469 scopus 로고    scopus 로고
    • Sublingual immunotherapy
    • 18499568
    • Frew AJ. Sublingual immunotherapy. N Engl J Med. 2008;358(21):2259-64.
    • (2008) N Engl J Med , vol.358 , Issue.21 , pp. 2259-2264
    • Frew, A.J.1
  • 13
    • 58149118102 scopus 로고    scopus 로고
    • Efficacy of grass pollen sublingual immunotherapy for three consecutive seasons and after cessation of treatment: The ECRIT study
    • 19076534
    • Ott H, Sieber J, Brehler R, Folster-Holst R, Kapp A, Klimek L, et al. Efficacy of grass pollen sublingual immunotherapy for three consecutive seasons and after cessation of treatment: the ECRIT study. Allergy. 2009;64(1):179-86.
    • (2009) Allergy , vol.64 , Issue.1 , pp. 179-186
    • Ott, H.1    Sieber, J.2    Brehler, R.3    Folster-Holst, R.4    Kapp, A.5    Klimek, L.6
  • 15
    • 0032737130 scopus 로고    scopus 로고
    • Respirable antisense oligonucleotide (RASON) therapy for allergic asthma
    • 18031178
    • Metzger WJ, Nyce JW. Respirable antisense oligonucleotide (RASON) therapy for allergic asthma. BioDrugs. 1999;12(4):237-43.
    • (1999) BioDrugs , vol.12 , Issue.4 , pp. 237-243
    • Metzger, W.J.1    Nyce, J.W.2
  • 16
    • 84861596408 scopus 로고    scopus 로고
    • Monoclonal antibodies for chronic refractory asthma and pipeline developments
    • 22306350
    • Polosa R, Casale T. Monoclonal antibodies for chronic refractory asthma and pipeline developments. Drug Discov Today. 2012;17(11-12):591-9.
    • (2012) Drug Discov Today , vol.17 , Issue.11-12 , pp. 591-599
    • Polosa, R.1    Casale, T.2
  • 17
    • 40049092917 scopus 로고    scopus 로고
    • Treatment strategies for allergy and asthma
    • 18274559
    • Holgate ST, Polosa R. Treatment strategies for allergy and asthma. Nat Rev Immunol. 2008;8(3):218-30.
    • (2008) Nat Rev Immunol , vol.8 , Issue.3 , pp. 218-230
    • Holgate, S.T.1    Polosa, R.2
  • 18
    • 61449339885 scopus 로고    scopus 로고
    • The relevance of IgE in the pathogenesis of allergy: The effect of an anti-IgE drug in asthma and other diseases
    • 19075978
    • Domingo C, Pacheco A, Hinojosa M, Bosque M. The relevance of IgE in the pathogenesis of allergy: the effect of an anti-IgE drug in asthma and other diseases. Recent Pat Inflamm Allergy Drug Discov. 2007;1(2):151-64.
    • (2007) Recent Pat Inflamm Allergy Drug Discov , vol.1 , Issue.2 , pp. 151-164
    • Domingo, C.1    Pacheco, A.2    Hinojosa, M.3    Bosque, M.4
  • 20
    • 0024491638 scopus 로고
    • Association of asthma with serum IgE levels and skin-test reactivity to allergens
    • 2911321
    • Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med. 1989;320(5):271-7.
    • (1989) N Engl J Med , vol.320 , Issue.5 , pp. 271-277
    • Burrows, B.1    Martinez, F.D.2    Halonen, M.3    Barbee, R.A.4    Cline, M.G.5
  • 21
    • 0018193792 scopus 로고
    • IgE receptors on human basophils: Relationship to serum IgE concentration
    • 371751 659631
    • Malveaux FJ, Conroy MC, Adkinson NF Jr, Lichtenstein NF. IgE receptors on human basophils: relationship to serum IgE concentration. J Clin Invest. 1978;62(1):176-81.
    • (1978) J Clin Invest , vol.62 , Issue.1 , pp. 176-181
    • Malveaux, F.J.1    Conroy, M.C.2    Adkinson, Jr.N.F.3    Lichtenstein, N.F.4
  • 23
    • 39849110433 scopus 로고    scopus 로고
    • IgE alone promotes human lung mast cell survival through the autocrine production of IL-6
    • 2257927 18215266
    • Cruse G, Cockerill S, Bradding P. IgE alone promotes human lung mast cell survival through the autocrine production of IL-6. BMC Immunol. 2008;9:2.
    • (2008) BMC Immunol , vol.9 , pp. 2
    • Cruse, G.1    Cockerill, S.2    Bradding, P.3
  • 24
    • 0029066660 scopus 로고
    • The high affinity IgE receptor (FcεRI) mediates IgE-dependent allergen presentation
    • 7759866
    • Maurer D, Ebner C, Reininger B, Fiebiger E, Kraft D, Kinet JP, et al. The high affinity IgE receptor (FcεRI) mediates IgE-dependent allergen presentation. J Immunol. 1995;154(12):6285-90.
    • (1995) J Immunol , vol.154 , Issue.12 , pp. 6285-6290
    • Maurer, D.1    Ebner, C.2    Reininger, B.3    Fiebiger, E.4    Kraft, D.5    Kinet, J.P.6
  • 25
    • 0035016019 scopus 로고    scopus 로고
    • Expression of the high-affinity IgE receptor on peripheral blood dendritic cells: Differential binding of IgE in atopic asthma
    • 11398078
    • Holloway JA, Holgate ST, Semper AE. Expression of the high-affinity IgE receptor on peripheral blood dendritic cells: differential binding of IgE in atopic asthma. J Allergy Clin Immunol. 2001;107(6):1009-18.
    • (2001) J Allergy Clin Immunol , vol.107 , Issue.6 , pp. 1009-1018
    • Holloway, J.A.1    Holgate, S.T.2    Semper, A.E.3
  • 26
    • 0030837924 scopus 로고    scopus 로고
    • Enhanced expression of high-affinity IgE receptor (FcεRI) alpha chain in human allergen-induced rhinitis with co-localization to mast cells, macrophages, eosinophils, and dendritic cells
    • 9257791
    • Rajakulasingam K, Durham SR, O'Brien F, Humbert M, Barata LT, Reece L, et al. Enhanced expression of high-affinity IgE receptor (FcεRI) alpha chain in human allergen-induced rhinitis with co-localization to mast cells, macrophages, eosinophils, and dendritic cells. J Allergy Clin Immunol. 1997;100(1):78-86.
    • (1997) J Allergy Clin Immunol , vol.100 , Issue.1 , pp. 78-86
    • Rajakulasingam, K.1    Durham, S.R.2    O'Brien, F.3    Humbert, M.4    Barata, L.T.5    Reece, L.6
  • 27
    • 0000898623 scopus 로고    scopus 로고
    • The pharmacological basis of anti-IgE therapy
    • 10657120
    • Chang TW. The pharmacological basis of anti-IgE therapy. Nat Biotechnol. 2000;18(2):157-62.
    • (2000) Nat Biotechnol , vol.18 , Issue.2 , pp. 157-162
    • Chang, T.W.1
  • 28
    • 0031065108 scopus 로고    scopus 로고
    • Down-regulation of FcεRI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody
    • 9013989
    • MacGlashan DW Jr, Bochner BS, Adelman DC, Jardieu PM, Togias A, McKenzie-White J, et al. Down-regulation of FcεRI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol. 1997;158(3):1438-45.
    • (1997) J Immunol , vol.158 , Issue.3 , pp. 1438-1445
    • Macglashan, Jr.D.W.1    Bochner, B.S.2    Adelman, D.C.3    Jardieu, P.M.4    Togias, A.5    McKenzie-White, J.6
  • 29
    • 4444232912 scopus 로고    scopus 로고
    • Effects of treatment with anti-immunoglobulin e antibody omalizumab on airway inflammation in allergic asthma
    • 15172898
    • Djukanovic R, Wilson SJ, Kraft M, Jarjour NN, Steel M, Chung KF, et al. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med. 2004;170(6):583-93.
    • (2004) Am J Respir Crit Care Med , vol.170 , Issue.6 , pp. 583-593
    • Djukanovic, R.1    Wilson, S.J.2    Kraft, M.3    Jarjour, N.N.4    Steel, M.5    Chung, K.F.6
  • 31
    • 20044362008 scopus 로고    scopus 로고
    • Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
    • 15679715
    • Humbert M, Beasley R, Ayres J, Slavin R, Hebert J, Bousquet J, et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy. 2005;60(3):309-16.
    • (2005) Allergy , vol.60 , Issue.3 , pp. 309-316
    • Humbert, M.1    Beasley, R.2    Ayres, J.3    Slavin, R.4    Hebert, J.5    Bousquet, J.6
  • 32
    • 0034881877 scopus 로고    scopus 로고
    • The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics
    • 11529281
    • Soler M, Matz J, Townley R, Buhl R, O'Brien J, Fox H, et al. The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. Eur Respir J. 2001;18(2):254-61.
    • (2001) Eur Respir J , vol.18 , Issue.2 , pp. 254-261
    • Soler, M.1    Matz, J.2    Townley, R.3    Buhl, R.4    O'Brien, J.5    Fox, H.6
  • 33
    • 0034907372 scopus 로고    scopus 로고
    • Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
    • 11496232
    • Busse W, Corren J, Lanier BQ, McAlary M, Fowler-Taylor A, Cioppa GD, et al. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol. 2001;108(2):184-90.
    • (2001) J Allergy Clin Immunol , vol.108 , Issue.2 , pp. 184-190
    • Busse, W.1    Corren, J.2    Lanier, B.Q.3    McAlary, M.4    Fowler-Taylor, A.5    Cioppa, G.D.6
  • 34
    • 0035989332 scopus 로고    scopus 로고
    • Omalizumab provides long-term control in patients with moderate-to-severe allergic asthma
    • 12166585
    • Buhl R, Soler M, Matz J, Townley R, O'Brien J, Noga O, et al. Omalizumab provides long-term control in patients with moderate-to-severe allergic asthma. Eur Respir J. 2002;20(1):73-8.
    • (2002) Eur Respir J , vol.20 , Issue.1 , pp. 73-78
    • Buhl, R.1    Soler, M.2    Matz, J.3    Townley, R.4    O'Brien, J.5    Noga, O.6
  • 36
    • 50549102147 scopus 로고    scopus 로고
    • Effectiveness of omalizumab in patients with inadequately controlled severe persistent allergic asthma: An open-label study
    • 18657960
    • Niven R, Chung KF, Panahloo Z, Blogg M, Ayre G. Effectiveness of omalizumab in patients with inadequately controlled severe persistent allergic asthma: an open-label study. Respir Med. 2008;102(10):1371-8.
    • (2008) Respir Med , vol.102 , Issue.10 , pp. 1371-1378
    • Niven, R.1    Chung, K.F.2    Panahloo, Z.3    Blogg, M.4    Ayre, G.5
  • 37
    • 11144356805 scopus 로고    scopus 로고
    • Efficacy and safety of a recombinant anti-immunoglobulin e antibody (omalizumab) in severe allergic asthma
    • 15080818
    • Holgate ST, Chuchalin AG, Hebert J, Lotvall J, Persson GB, Chung KF, et al. Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma. Clin Exp Allergy. 2004;34(4):632-8.
    • (2004) Clin Exp Allergy , vol.34 , Issue.4 , pp. 632-638
    • Holgate, S.T.1    Chuchalin, A.G.2    Hebert, J.3    Lotvall, J.4    Persson, G.B.5    Chung, K.F.6
  • 38
    • 3042786151 scopus 로고    scopus 로고
    • Efficacy and tolerability of anti-immunoglobulin e therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthma
    • 15180756
    • Ayres JG, Higgins B, Chilvers ER, Ayre G, Blogg M, Fox H. Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthma. Allergy. 2004;59(7):701-8.
    • (2004) Allergy , vol.59 , Issue.7 , pp. 701-708
    • Ayres, J.G.1    Higgins, B.2    Chilvers, E.R.3    Ayre, G.4    Blogg, M.5    Fox, H.6
  • 39
    • 71249102935 scopus 로고    scopus 로고
    • Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma
    • 19910033
    • Lanier B, Bridges T, Kulus M, Taylor AF, Berhane I, Vidaurre CF. Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma. J Allergy Clin Immunol. 2009;124(6):1210-6.
    • (2009) J Allergy Clin Immunol , vol.124 , Issue.6 , pp. 1210-1216
    • Lanier, B.1    Bridges, T.2    Kulus, M.3    Taylor, A.F.4    Berhane, I.5    Vidaurre, C.F.6
  • 40
    • 84880783880 scopus 로고    scopus 로고
    • Add-on omalizumab in children with severe allergic asthma: A 1-year real life survey
    • 23520319
    • Deschildre A, Marguet C, Salleron J, Pin I, Rittie JL, Derelle J, et al. Add-on omalizumab in children with severe allergic asthma: a 1-year real life survey. Eur Respir J. 2013;42(5):1224-33.
    • (2013) Eur Respir J , vol.42 , Issue.5 , pp. 1224-1233
    • Deschildre, A.1    Marguet, C.2    Salleron, J.3    Pin, I.4    Rittie, J.L.5    Derelle, J.6
  • 41
    • 77955663329 scopus 로고    scopus 로고
    • Omalizumab reduces oral corticosteroid use in patients with severe allergic asthma: Real-life data
    • 20599369
    • Molimard M, Buhl R, Niven R, Le Gros V, Thielen A, Thirlwell J, et al. Omalizumab reduces oral corticosteroid use in patients with severe allergic asthma: real-life data. Respir Med. 2010;104(9):1381-5.
    • (2010) Respir Med , vol.104 , Issue.9 , pp. 1381-1385
    • Molimard, M.1    Buhl, R.2    Niven, R.3    Le Gros, V.4    Thielen, A.5    Thirlwell, J.6
  • 43
    • 82655173707 scopus 로고    scopus 로고
    • Omalizumab decreases exacerbation frequency, oral intake of corticosteroids and peripheral blood eosinophils in atopic patients with uncontrolled asthma
    • 22122813
    • Pelaia G, Gallelli L, Romeo P, Renda T, Busceti MT, Proietto A, et al. Omalizumab decreases exacerbation frequency, oral intake of corticosteroids and peripheral blood eosinophils in atopic patients with uncontrolled asthma. Int J Clin Pharmacol Ther. 2011;49(12):713-21.
    • (2011) Int J Clin Pharmacol Ther , vol.49 , Issue.12 , pp. 713-721
    • Pelaia, G.1    Gallelli, L.2    Romeo, P.3    Renda, T.4    Busceti, M.T.5    Proietto, A.6
  • 44
    • 84860247083 scopus 로고    scopus 로고
    • Omalizumab and asthma control in patients with moderate-to-severe allergic asthma: A 6-year pragmatic data review
    • 22525394
    • Storms W, Bowdish MS, Farrar JR. Omalizumab and asthma control in patients with moderate-to-severe allergic asthma: a 6-year pragmatic data review. Allergy Asthma Proc. 2012;33(2):172-7.
    • (2012) Allergy Asthma Proc , vol.33 , Issue.2 , pp. 172-177
    • Storms, W.1    Bowdish, M.S.2    Farrar, J.R.3
  • 45
    • 84856773097 scopus 로고    scopus 로고
    • Long-term omalizumab treatment in severe allergic asthma: The South-Eastern Mediterranean "real-life" experience
    • 22155001
    • Tzortzaki EG, Georgiou A, Kampas D, Lemessios M, Markatos M, Adamidi T, et al. Long-term omalizumab treatment in severe allergic asthma: the South-Eastern Mediterranean "real-life" experience. Pulm Pharmacol Ther. 2012;25(1):77-82.
    • (2012) Pulm Pharmacol Ther , vol.25 , Issue.1 , pp. 77-82
    • Tzortzaki, E.G.1    Georgiou, A.2    Kampas, D.3    Lemessios, M.4    Markatos, M.5    Adamidi, T.6
  • 46
    • 84880537802 scopus 로고    scopus 로고
    • Assessment of long-term omalizumab treatment in patients with severe allergic asthma long-term omalizumab treatment in severe asthma
    • 23557459
    • Ozgur ES, Ozge C, Ilvan A, Nayci SA. Assessment of long-term omalizumab treatment in patients with severe allergic asthma long-term omalizumab treatment in severe asthma. J Asthma. 2013;50(6):687-94.
    • (2013) J Asthma , vol.50 , Issue.6 , pp. 687-694
    • Ozgur, E.S.1    Ozge, C.2    Ilvan, A.3    Nayci, S.A.4
  • 48
    • 84863307371 scopus 로고    scopus 로고
    • The oral corticosteroid-sparing effect of omalizumab in children with severe asthma
    • 22685051
    • Brodlie M, McKean MC, Moss S, Spencer DA. The oral corticosteroid-sparing effect of omalizumab in children with severe asthma. Arch Dis Child. 2012;97(7):604-9.
    • (2012) Arch Dis Child , vol.97 , Issue.7 , pp. 604-609
    • Brodlie, M.1    McKean, M.C.2    Moss, S.3    Spencer, D.A.4
  • 49
    • 9244237003 scopus 로고    scopus 로고
    • Reversibility of airway inflammation and remodelling following cessation of antigenic challenge in a model of chronic asthma
    • 15544607
    • Kumar RK, Herbert C, Kasper M. Reversibility of airway inflammation and remodelling following cessation of antigenic challenge in a model of chronic asthma. Clin Exp Allergy. 2004;34(11):1796-802.
    • (2004) Clin Exp Allergy , vol.34 , Issue.11 , pp. 1796-1802
    • Kumar, R.K.1    Herbert, C.2    Kasper, M.3
  • 50
    • 79961127439 scopus 로고    scopus 로고
    • Can anti-IgE therapy prevent airway remodeling in allergic asthma?
    • 21645010
    • Rabe KF, Calhoun WJ, Smith N, Jimenez P. Can anti-IgE therapy prevent airway remodeling in allergic asthma? Allergy. 2011;66(9):1142-51.
    • (2011) Allergy , vol.66 , Issue.9 , pp. 1142-1151
    • Rabe, K.F.1    Calhoun, W.J.2    Smith, N.3    Jimenez, P.4
  • 51
    • 80054703208 scopus 로고    scopus 로고
    • Oral corticosteroid sparing with omalizumab in severe allergic (IgE-mediated) asthma patients
    • 21933100
    • Siergiejko Z, Swiebocka E, Smith N, Peckitt C, Leo J, Peachey G, et al. Oral corticosteroid sparing with omalizumab in severe allergic (IgE-mediated) asthma patients. Curr Med Res Opin. 2011;27(11):2223-8.
    • (2011) Curr Med Res Opin , vol.27 , Issue.11 , pp. 2223-2228
    • Siergiejko, Z.1    Swiebocka, E.2    Smith, N.3    Peckitt, C.4    Leo, J.5    Peachey, G.6
  • 52
    • 32644435868 scopus 로고    scopus 로고
    • Benefits of low weekly doses of methotrexate in steroid-dependent asthmatic patients: A double-blind, randomized, placebo-controlled study
    • 16099632
    • Comet R, Domingo C, Larrosa M, Moron A, Rue M, Amengual MJ, et al. Benefits of low weekly doses of methotrexate in steroid-dependent asthmatic patients: a double-blind, randomized, placebo-controlled study. Respir Med. 2006;100(3):411-9.
    • (2006) Respir Med , vol.100 , Issue.3 , pp. 411-419
    • Comet, R.1    Domingo, C.2    Larrosa, M.3    Moron, A.4    Rue, M.5    Amengual, M.J.6
  • 53
    • 64249108739 scopus 로고    scopus 로고
    • Twelve years' experience with methotrexate for GINA treatment step 5 asthma patients
    • 19192981
    • Domingo C, Moreno A, Amengual MJ, Comet R, Lujan M. Twelve years' experience with methotrexate for GINA treatment step 5 asthma patients. Curr Med Res Opin. 2009;25(2):367-74.
    • (2009) Curr Med Res Opin , vol.25 , Issue.2 , pp. 367-374
    • Domingo, C.1    Moreno, A.2    Amengual, M.J.3    Comet, R.4    Lujan, M.5
  • 54
    • 58149129505 scopus 로고    scopus 로고
    • Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations
    • Slavin RG, Ferioli C, Tannenbaum SJ, Martin C, Blogg M, Lowe PJ. Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations. J Allergy Clin Immunol. 2009;123(1):107-13.e3.
    • (2009) J Allergy Clin Immunol. , vol.123 , Issue.1
    • Slavin, R.G.1    Ferioli, C.2    Tannenbaum, S.J.3    Martin, C.4    Blogg, M.5    Lowe, P.J.6
  • 55
    • 34548479249 scopus 로고    scopus 로고
    • CD-sens and clinical changes during withdrawal of Xolair after 6 years of treatment
    • 17845588
    • Nopp A, Johansson SG, Ankerst J, Palmqvist M, Oman H. CD-sens and clinical changes during withdrawal of Xolair after 6 years of treatment. Allergy. 2007;62(10):1175-81.
    • (2007) Allergy , vol.62 , Issue.10 , pp. 1175-1181
    • Nopp, A.1    Johansson, S.G.2    Ankerst, J.3    Palmqvist, M.4    Oman, H.5
  • 58
    • 79960163500 scopus 로고    scopus 로고
    • Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgE
    • 3162660 21392073
    • Lowe PJ, Renard D. Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgE. Br J Clin Pharmacol. 2011;72(2):306-20.
    • (2011) Br J Clin Pharmacol , vol.72 , Issue.2 , pp. 306-320
    • Lowe, P.J.1    Renard, D.2
  • 59
    • 84875641402 scopus 로고    scopus 로고
    • Can omalizumab be effective in chronic eosinophilic pneumonia?
    • 23276861
    • Domingo C, Pomares X. Can omalizumab be effective in chronic eosinophilic pneumonia? Chest. 2013;143(1):274.
    • (2013) Chest , vol.143 , Issue.1 , pp. 274
    • Domingo, C.1    Pomares, X.2
  • 61
    • 84860679595 scopus 로고    scopus 로고
    • Asthma phenotypes: The evolution from clinical to molecular approaches
    • 22561835
    • Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012;18(5):716-25.
    • (2012) Nat Med , vol.18 , Issue.5 , pp. 716-725
    • Wenzel, S.E.1
  • 62
    • 35649028488 scopus 로고    scopus 로고
    • Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    • 2000427 17898169
    • Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA. 2007;104(40):15858-63.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.40 , pp. 15858-15863
    • Woodruff, P.G.1    Boushey, H.A.2    Dolganov, G.M.3    Barker, C.S.4    Yang, Y.H.5    Donnelly, S.6
  • 66
    • 84881180798 scopus 로고    scopus 로고
    • Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids
    • 23791506
    • Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, et al. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol. 2013;132(2):305-12.
    • (2013) J Allergy Clin Immunol , vol.132 , Issue.2 , pp. 305-312
    • Kanemitsu, Y.1    Matsumoto, H.2    Izuhara, K.3    Tohda, Y.4    Kita, H.5    Horiguchi, T.6
  • 67
    • 84876883293 scopus 로고    scopus 로고
    • Exploring the effects of omalizumab in allergic asthma: An analysis of biomarkers in the EXTRA study
    • 23471469
    • Hanania NA, Wenzel S, Rosen K, Hsieh HJ, Mosesova S, Choy DF, et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med. 2013;187(8):804-11.
    • (2013) Am J Respir Crit Care Med , vol.187 , Issue.8 , pp. 804-811
    • Hanania, N.A.1    Wenzel, S.2    Rosen, K.3    Hsieh, H.J.4    Mosesova, S.5    Choy, D.F.6
  • 68
    • 0016684351 scopus 로고
    • Local production of specific IgE antibodies in allergic rhinitis patients with negative skin tests
    • 49744
    • Huggins K, Brostoff J. Local production of specific IgE antibodies in allergic rhinitis patients with negative skin tests. Lancet. 1975;2(7926):148-50.
    • (1975) Lancet , vol.2 , Issue.7926 , pp. 148-150
    • Huggins, K.1    Brostoff, J.2
  • 69
    • 0036408870 scopus 로고    scopus 로고
    • Atypical nasal challenges in patients with idiopathic rhinitis: More evidence for the existence of allergy in the absence of atopy?
    • 12372122
    • Carney AS, Powe DG, Huskisson RS, Jones NS. Atypical nasal challenges in patients with idiopathic rhinitis: more evidence for the existence of allergy in the absence of atopy? Clin Exp Allergy. 2002;32(10):1436-40.
    • (2002) Clin Exp Allergy , vol.32 , Issue.10 , pp. 1436-1440
    • Carney, A.S.1    Powe, D.G.2    Huskisson, R.S.3    Jones, N.S.4
  • 70
    • 0142074306 scopus 로고    scopus 로고
    • 'Entopy': Localized mucosal allergic disease in the absence of systemic responses for atopy
    • 14519143
    • Powe DG, Jagger C, Kleinjan A, Carney AS, Jenkins D, Jones NS. 'Entopy': localized mucosal allergic disease in the absence of systemic responses for atopy. Clin Exp Allergy. 2003;33(10):1374-9.
    • (2003) Clin Exp Allergy , vol.33 , Issue.10 , pp. 1374-1379
    • Powe, D.G.1    Jagger, C.2    Kleinjan, A.3    Carney, A.S.4    Jenkins, D.5    Jones, N.S.6
  • 71
    • 34047109052 scopus 로고    scopus 로고
    • Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis
    • 17337294
    • Rondón C, Romero JJ, López S, Antúnez C, Martín-Casañez E, Torres MJ, et al. Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. J Allergy Clin Immunol. 2007;119(4):899-905.
    • (2007) J Allergy Clin Immunol , vol.119 , Issue.4 , pp. 899-905
    • Rondón, C.1    Romero, J.J.2    López, S.3    Antúnez, C.4    Martín-Casañez, E.5    Torres, M.J.6
  • 72
    • 67749101990 scopus 로고    scopus 로고
    • Localized immunoglobulin e expression in allergic rhinitis and nasal polyposis
    • 19417663
    • Wise SK, Ahn CN, Schlosser RJ. Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis. Curr Opin Otolaryngol Head Neck Surg. 2009;17(3):216-22.
    • (2009) Curr Opin Otolaryngol Head Neck Surg , vol.17 , Issue.3 , pp. 216-222
    • Wise, S.K.1    Ahn, C.N.2    Schlosser, R.J.3
  • 73
    • 73449091211 scopus 로고    scopus 로고
    • Local B cells and IgE production in the oesophageal: Mucosa in eosinophilic oesophagitis
    • 2791234 19528036
    • Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, et al. Local B cells and IgE production in the oesophageal: mucosa in eosinophilic oesophagitis. Gut. 2010;59(1):12-20.
    • (2010) Gut , vol.59 , Issue.1 , pp. 12-20
    • Vicario, M.1    Blanchard, C.2    Stringer, K.F.3    Collins, M.H.4    Mingler, M.K.5    Ahrens, A.6
  • 74
    • 0032725001 scopus 로고    scopus 로고
    • The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: More similarities than differences
    • 10529782
    • Humbert M, Menz G, Ying S, Corrigan CJ, Robinson DS, Durham SR, et al. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today. 1999;20(11):528-33.
    • (1999) Immunol Today , vol.20 , Issue.11 , pp. 528-533
    • Humbert, M.1    Menz, G.2    Ying, S.3    Corrigan, C.J.4    Robinson, D.S.5    Durham, S.R.6
  • 75
    • 3142512604 scopus 로고    scopus 로고
    • Impact of inadequately controlled asthma: A need for targeted therapy?
    • 15153080
    • Mehlhop PD, Blake K. Impact of inadequately controlled asthma: a need for targeted therapy? J Clin Pharm Ther. 2004;29(3):189-94.
    • (2004) J Clin Pharm Ther , vol.29 , Issue.3 , pp. 189-194
    • Mehlhop, P.D.1    Blake, K.2
  • 76
    • 84880851544 scopus 로고    scopus 로고
    • A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma
    • 23579324
    • Garcia G, Magnan A, Chiron R, Contin-Bordes C, Berger P, Taille C, et al. A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma. Chest. 2013;144(2):411-9.
    • (2013) Chest , vol.144 , Issue.2 , pp. 411-419
    • Garcia, G.1    Magnan, A.2    Chiron, R.3    Contin-Bordes, C.4    Berger, P.5    Taille, C.6
  • 77
    • 33845808267 scopus 로고    scopus 로고
    • Immunoglobulin E: Role in asthma and allergic disease: Lessons from the clinic
    • 17000005
    • Owen CE. Immunoglobulin E: role in asthma and allergic disease: lessons from the clinic. Pharmacol Ther. 2007;113(1):121-33.
    • (2007) Pharmacol Ther , vol.113 , Issue.1 , pp. 121-133
    • Owen, C.E.1
  • 80
    • 0031110132 scopus 로고    scopus 로고
    • Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics
    • 9120316
    • Ying S, Humbert M, Barkans J, Corrigan CJ, Pfister R, Menz G, et al. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol. 1997;158(7):3539-44.
    • (1997) J Immunol , vol.158 , Issue.7 , pp. 3539-3544
    • Ying, S.1    Humbert, M.2    Barkans, J.3    Corrigan, C.J.4    Pfister, R.5    Menz, G.6
  • 81
    • 0030922389 scopus 로고    scopus 로고
    • Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma
    • 9155833
    • Humbert M, Durham SR, Kimmitt P, Powell N, Assoufi B, Pfister R, et al. Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma. J Allergy Clin Immunol. 1997;99(5):657-65.
    • (1997) J Allergy Clin Immunol , vol.99 , Issue.5 , pp. 657-665
    • Humbert, M.1    Durham, S.R.2    Kimmitt, P.3    Powell, N.4    Assoufi, B.5    Pfister, R.6
  • 82
    • 4944252186 scopus 로고    scopus 로고
    • Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis
    • 15480349
    • Van Zele T, Gevaert P, Watelet JB, Claeys G, Holtappels G, Claeys C, et al. Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. J Allergy Clin Immunol. 2004;114(4):981-3.
    • (2004) J Allergy Clin Immunol , vol.114 , Issue.4 , pp. 981-983
    • Van Zele, T.1    Gevaert, P.2    Watelet, J.B.3    Claeys, G.4    Holtappels, G.5    Claeys, C.6
  • 83
    • 25844507793 scopus 로고    scopus 로고
    • An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis
    • 16218508
    • Zhang N, Gevaert P, van Zele T, Perez-Novo C, Patou J, Holtappels G, et al. An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis. Rhinology. 2005;43(3):162-8.
    • (2005) Rhinology , vol.43 , Issue.3 , pp. 162-168
    • Zhang, N.1    Gevaert, P.2    Van Zele, T.3    Perez-Novo, C.4    Patou, J.5    Holtappels, G.6
  • 84
    • 78650035276 scopus 로고    scopus 로고
    • Mucosal tissue polyclonal IgE is functional in response to allergen and SEB
    • 20659077
    • Zhang N, Holtappels G, Gevaert P, Patou J, Dhaliwal B, Gould H, et al. Mucosal tissue polyclonal IgE is functional in response to allergen and SEB. Allergy. 2011;66(1):141-8.
    • (2011) Allergy , vol.66 , Issue.1 , pp. 141-148
    • Zhang, N.1    Holtappels, G.2    Gevaert, P.3    Patou, J.4    Dhaliwal, B.5    Gould, H.6
  • 86
    • 84890312493 scopus 로고    scopus 로고
    • Against all odds: Anti-IgE for intrinsic asthma?
    • Lommatzsch M, Korn S, Buhl R, Virchow JC. Against all odds: anti-IgE for intrinsic asthma? Thorax. 2014;63(1):94-6.
    • (2014) Thorax , vol.63 , Issue.1 , pp. 94-96
    • Lommatzsch, M.1    Korn, S.2    Buhl, R.3    Virchow, J.C.4
  • 87
    • 0034948480 scopus 로고    scopus 로고
    • Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival
    • 11420049
    • Kalesnikoff J, Huber M, Lam V, Damen JE, Zhang J, Siraganian RP, et al. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity. 2001;14(6):801-11.
    • (2001) Immunity , vol.14 , Issue.6 , pp. 801-811
    • Kalesnikoff, J.1    Huber, M.2    Lam, V.3    Damen, J.E.4    Zhang, J.5    Siraganian, R.P.6
  • 88
    • 78651443886 scopus 로고    scopus 로고
    • Beneficial effects of treatment with anti-IgE antibodies (omalizumab) in a patient with severe asthma and negative skin-prick test results
    • 21208879
    • van den Berge M, Pauw RG, de Monchy JG, van Minnen CA, Postma DS, Kerstjens HA. Beneficial effects of treatment with anti-IgE antibodies (omalizumab) in a patient with severe asthma and negative skin-prick test results. Chest. 2011;139(1):190-3.
    • (2011) Chest , vol.139 , Issue.1 , pp. 190-193
    • Van Den Berge, M.1    Pauw, R.G.2    De Monchy, J.G.3    Van Minnen, C.A.4    Postma, D.S.5    Kerstjens, H.A.6
  • 91
    • 0027965679 scopus 로고
    • Inhibition of human IgE synthesis by anti-IgE antibodies requires divalent recognition
    • 7522164
    • Stampfli MR, Miescher S, Aebischer I, Zurcher AW, Stadler BM. Inhibition of human IgE synthesis by anti-IgE antibodies requires divalent recognition. Eur J Immunol. 1994;24(9):2161-7.
    • (1994) Eur J Immunol , vol.24 , Issue.9 , pp. 2161-2167
    • Stampfli, M.R.1    Miescher, S.2    Aebischer, I.3    Zurcher, A.W.4    Stadler, B.M.5
  • 93
    • 84880536450 scopus 로고    scopus 로고
    • Omalizumab attenuates airway inflammation and interleukin-5 production by mononuclear cells in patients with severe allergic asthma
    • 23711861
    • Takaku Y, Soma T, Nishihara F, Nakagome K, Kobayashi T, Hagiwara K, et al. Omalizumab attenuates airway inflammation and interleukin-5 production by mononuclear cells in patients with severe allergic asthma. Int Arch Allergy Immunol. 2013;161(Suppl 2):107-17.
    • (2013) Int Arch Allergy Immunol , vol.161 , Issue.SUPPL. 2 , pp. 107-117
    • Takaku, Y.1    Soma, T.2    Nishihara, F.3    Nakagome, K.4    Kobayashi, T.5    Hagiwara, K.6
  • 94
    • 84881351958 scopus 로고    scopus 로고
    • Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma
    • 3544267 23326187
    • Walsh GM. Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma. Biologics. 2013;7:7-11.
    • (2013) Biologics , vol.7 , pp. 7-11
    • Walsh, G.M.1
  • 95
    • 84900448280 scopus 로고    scopus 로고
    • Induced sputum versus exhaled nitric oxide for the evaluation of airway inflammation in allergic pediatric asthma patients treated with omalizumab
    • (4-Meeting abstracts)
    • Domingo X, Bosque M, Valdesoiro L, Larramona H, Vigil L, Maestro A, et al. Induced sputum versus exhaled nitric oxide for the evaluation of airway inflammation in allergic pediatric asthma patients treated with omalizumab. Chest. 2013;144(4-Meeting abstracts):761A.
    • (2013) Chest , vol.144
    • Domingo, X.1    Bosque, M.2    Valdesoiro, L.3    Larramona, H.4    Vigil, L.5    Maestro, A.6
  • 96
    • 84890117435 scopus 로고    scopus 로고
    • Periostin, a novel biomarker of Th2-driven asthma
    • 24247042
    • Parulekar AD, Atik MA, Hanania NA. Periostin, a novel biomarker of Th2-driven asthma. Curr Opin Pulm Med. 2014;20(1):60-5.
    • (2014) Curr Opin Pulm Med , vol.20 , Issue.1 , pp. 60-65
    • Parulekar, A.D.1    Atik, M.A.2    Hanania, N.A.3
  • 97
    • 67650938578 scopus 로고    scopus 로고
    • Relationship between omalizumab pharmacokinetics, IgE pharmacodynamics and symptoms in patients with severe persistent allergic (IgE-mediated) asthma
    • 2732941 19660004
    • Lowe PJ, Tannenbaum S, Gautier A, Jimenez P. Relationship between omalizumab pharmacokinetics, IgE pharmacodynamics and symptoms in patients with severe persistent allergic (IgE-mediated) asthma. Br J Clin Pharmacol. 2009;68(1):61-76.
    • (2009) Br J Clin Pharmacol , vol.68 , Issue.1 , pp. 61-76
    • Lowe, P.J.1    Tannenbaum, S.2    Gautier, A.3    Jimenez, P.4
  • 98
    • 0034502211 scopus 로고    scopus 로고
    • The relationship between serum IgE and surface levels of FcεRI on human leukocytes in various diseases: Correlation of expression with FcεRI on basophils but not on monocytes or eosinophils
    • 10984372
    • Saini SS, Klion AD, Holland SM, Hamilton RG, Bochner BS, Macglashan DW Jr. The relationship between serum IgE and surface levels of FcεRI on human leukocytes in various diseases: correlation of expression with FcεRI on basophils but not on monocytes or eosinophils. J Allergy Clin Immunol. 2000;106(3):514-20.
    • (2000) J Allergy Clin Immunol , vol.106 , Issue.3 , pp. 514-520
    • Saini, S.S.1    Klion, A.D.2    Holland, S.M.3    Hamilton, R.G.4    Bochner, B.S.5    Macglashan, Jr.D.W.6
  • 100
  • 101
    • 84893678640 scopus 로고    scopus 로고
    • Eligibility for treatment with omalizumab in Italy and Germany
    • 24315468
    • Buhl R, Marco AG, Cohen D, Canonica GW. Eligibility for treatment with omalizumab in Italy and Germany. Respir Med. 2014;108(1):50-6.
    • (2014) Respir Med , vol.108 , Issue.1 , pp. 50-56
    • Buhl, R.1    Marco, A.G.2    Cohen, D.3    Canonica, G.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.