Clinical characteristics and possible phenotypes of an adult severe asthma population

Respiratory Medicine

Volumn 106, Issue 1, 2012, Pages 47-56

  De Carvalho Pinto, Regina Maria ^a   Cukier, Alberto ^a   Angelini, Luciene ^a   Antonangelo, Leila ^a   Mauad, Thais ^a   Dolhnikoff, Marisa ^a   Rabe, Klaus F ^b   Stelmach, Rafael ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b KRANKENHAUS GROSSHANSDORF   (Germany)

Author keywords

Asthma; Atopy; Characteristics; Phenotypes; Severe asthma; Sputum eosinophils

Indexed keywords

ADULT; AIRWAY OBSTRUCTION; AIRWAY RESISTANCE; ANXIETY; ARTICLE; ASTHMA; ASTHMA CONTROL QUESTIONNAIRE; ASTHMA CONTROL TEST; ATOPY; BECK DEPRESSION INVENTORY; BODY MASS; CLINICAL FEATURE; COMORBIDITY; DEPRESSION; DISEASE SEVERITY; EOSINOPHIL; EOSINOPHILIA; EPITHELIUM CELL; FEMALE; HUMAN; INFLAMMATION; INTENSIVE CARE; LYMPHOCYTE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; SHORT FORM 36; SPUTUM LEVEL; SQUAMOUS CELL; ST GEORGE RESPIRATORY QUESTIONNAIRE; STATE TRAIT ANXIETY INVENTORY;

ADOLESCENT; ADULT; AGED; AIRWAY RESISTANCE; ANXIETY; ASTHMA; BODY MASS INDEX; BRAZIL; CLINICAL TRIALS AS TOPIC; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DEPRESSION; EOSINOPHILS; FEMALE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; LEUKOCYTE COUNT; MALE; MIDDLE AGED; NITRIC OXIDE; PHENOTYPE; RESPIRATORY FUNCTION TESTS; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; SPUTUM; YOUNG ADULT;

EID: 82955247601     PISSN: 09546111     EISSN: 15323064     Source Type: Journal    
DOI: 10.1016/j.rmed.2011.08.013     Document Type: Article

References (43)

1. E. Bateman, H. Boushey, J. Bousquet, W. Busse, T. Clark, and R. Pauwels Can guideline-defined asthma control be achieved? The gaining optimal asthma control STUDY Am J Respir Crit Care Med 170 8 2004 836 844 (Pubitemid 39346477)
2. P. Jeffery, R. Godfrey, E. Adelroth, F. Nelson, A. Rogers, and S. Johansson Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study Am Rev Respir Dis 145 4 Pt 1 1992 890 899
3. S. Suissa, P. Ernst, S. Benayoun, M. Baltzan, and B. Cai Low-dose inhaled corticosteroids and the prevention of death from asthma N Engl J Med 343 5 2000 332 336 (Pubitemid 30616699)
4. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma Eur Respir J 22 3 2003 470 477
5. C. Dolan, K. Fraher, E. Bleecker, L. Borish, B. Chipps, and M. Hayden Design and baseline characteristics of the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma Ann Allergy Asthma Immunol 92 1 2004 32 39 (Pubitemid 38113629)
6. G. Sembajwe, M. Cifuentes, S. Tak, D. Kriebel, R. Gore, and L. Punnett National income, self-reported wheezing and asthma diagnosis from the world health survey Eur Respir J 35 2 2010 279 286
7. P.M. Santos, A.J. D'Oliveira, L.A. Noblat, A. Machado, A. Noblat, and A. Cruz Predictors of adherence to treatment in patients with severe asthma treated at a referral center in Bahia, Brazil J Bras Pneumol 34 12 2008 995 1002
8. R. Franco, A. Santos, H. do Nascimento, C. Souza-Machado, E. Ponte, and A. Souza-Machado Cost-effectiveness analysis of a state funded programme for control of severe asthma BMC Public Health 7 2007 82
9. C. Souza-Machado, A. Souza-Machado, R. Franco, E. Ponte, M. Barreto, and L. Rodrigues Rapid reduction in hospitalisations after an intervention to manage severe asthma Eur Respir J 35 3 2010 515 521
10. R. Franco, H. Nascimento, A. Cruz, A. Santos, C. Souza-Machado, and E. Ponte The economic impact of severe asthma to low-income families Allergy 64 3 2009 478 483
11. A. Cruz, and P. Bousquet The unbearable cost of severe asthma in underprivileged populations Allergy 64 3 2009 319 321
12. W. Moore, E. Bleecker, D. Curran-Everett, S. Erzurum, B. Ameredes, and L. Bacharier Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's severe asthma research program J Allergy Clin Immunol 119 2 2007 405 413 (Pubitemid 46210080)
13. C. Miranda, A. Busacker, S. Balzar, J. Trudeau, and S. Wenzel Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation J Allergy Clin Immunol 113 1 2004 101 108 (Pubitemid 38096168)
14. Committee GE, Committee, GS. Global strategy for asthma management and prevention. Available in: http://www.ginasthma.com.
15. M. Leite, E. Ponte, J. Petroni, A. D'Oliveira Júnior, E. Pizzichini, and A. Cruz Evaluation of the asthma control questionnaire validated for use in Brazil J Bras Pneumol 34 10 2008 756 763
16. R. Nathan, C. Sorkness, M. Kosinski, M. Schatz, J. Li, and P. Marcus Development of the asthma control test: a survey for assessing asthma control J Allergy Clin Immunol 113 1 2004 59 65 (Pubitemid 38096162)
17. M. Ferrer, C. Villasante, J. Alonso, V. Sobradillo, R. Gabriel, and G. Vilagut Interpretation of quality of life scores from the St George's respiratory questionnaire Eur Respir J 19 3 2002 405 413 (Pubitemid 34256952)
18. A.T. Beck, C.H. Ward, M. Mendelson, J. Mock, and J. Erbaugh An inventory for measuring depression Arch Gen Psychiatry 4 1961 561 571
19. C.D. Spielberger Manual for the state-trait anxiety inventory 1983 Consulting Psychologists Press Palo Alto, California
20. M.R. Miller, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, and A. Coates Standardisation of spirometry Eur Respir J 26 2 2005 319 338 (Pubitemid 41079078)
21. P.H. Quanjer, G.J. Tammeling, J.E. Cotes, O.F. Pedersen, R. Peslin, and J.C. Yernault Lung volumes and forced ventilatory flows. Report Working Party Standardization of lung function tests, European Community for Steel and Coal. Official statement of the European respiratory Society Eur Respir J Suppl 16 1993 5 40
22. A.H. Morris, R.E. Kanner, and R.O. Crapo Clinical pulmonary function testing: a manual of uniform laboratory procedures 1984 Intermountain Thoracic Society Salt Lake City, UT
23. U. Santos, S. Gannam, J. Abe, P. Esteves, M. Freitas-Filho, and T. Wakassa Emprego da determinaão de monóxido de carbono no ar exalado para a detecão do consumo de tabaco J Bras Pneumol 27 5 2001 231 236 Set-Oct
24. J. Oppenheimer, and H. Nelson Skin testing Ann Allergy Asthma Immunol 96 2 Suppl. 1 2006 S6 S12
25. E. Pizzichini, M. Pizzichini, A. Efthimiadis, S. Evans, M. Morris, and D. Squillace Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements Am J Respir Crit Care Med 154 2 Pt 1 1996 308 317 (Pubitemid 26269096)
26. I. Pavord, M. Pizzichini, E. Pizzichini, and F. Hargreave The use of induced sputum to investigate airway inflammation Thorax 52 6 1997 498 501 (Pubitemid 27298498)
27. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 Am J Respir Crit Care Med 171 8 2005 912 930
28. A. ten Brinke, J. van Dissel, P. Sterk, A. Zwinderman, K. Rabe, and E. Bel Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection J Allergy Clin Immunol 107 3 2001 449 454 (Pubitemid 32210024)
29. E. Ponte, R. Franco, A. Souza-Machado, C. Souza-Machado, and A. Cruz Impact that a program to control severe asthma has on the use of Unified Health System resources in Brazil J Bras Pneumol 33 1 2007 15 19
30. A. Araujo, E. Ferraz, M.C. Borges, J. Filho, and E. Vianna Investigation of factors associated with difficult-to-control asthma J Bras Pneumol 33 5 2007 495 501
31. R. Stelmach, T. do Patrocínio, M. Nunes, M. Ribeiro, and A. Cukier Effect of treating allergic rhinitis with corticosteroids in patients with mild-to-moderate persistent asthma Chest 128 5 2005 3140 3147 (Pubitemid 41698633)
32. M. Littner, F. Leung, Ballard En, B. Huang, and N. Samra Effects of 24 weeks of lansoprazole therapy on asthma symptoms, exacerbations, quality of life, and pulmonary function in adult asthmatic patients with acid reflux symptoms Chest 128 3 2005 1128 1135 (Pubitemid 41324386)
33. R.S. Alves, F.A. Vianna, and C. Pereira Clinical phenotypes of severe asthma J Bras Pneumol 34 9 2008 646 653
34. C. Sant'Anna, R. Stelmach, M. Zanetti Feltrin, W. Filho, T. Chiba, and A. Cukier Evaluation of health-related quality of life in low-income patients with COPD receiving long-term oxygen therapy Chest 123 1 2003 136 141 (Pubitemid 36126725)
35. R. Incalzi, V. Bellia, F. Catalano, N. Scichilone, C. Imperiale, and S. Maggi Evaluation of health outcomes in elderly patients with asthma and COPD using disease-specific and generic instruments: the Salute Respiratoria nell'Anziano (Sa.R.A.) Study Chest 120 3 2001 734 742 (Pubitemid 32885443)
36. K. Nishimura, T. Hajiro, T. Oga, M. Tsukino, and A. Ikeda Health-related quality of life in stable asthma: what are remaining quality of life problems in patients with well-controlled asthma? J Asthma 41 1 2004 57 65 (Pubitemid 38366874)
37. D. Robinson, D. Campbell, S. Durham, J. Pfeffer, P. Barnes, and K. Chung Systematic assessment of difficult-to-treat asthma Eur Respir J 22 3 2003 478 483 (Pubitemid 37098929)
38. A. Busacker, J.J. Newell, T. Keefe, E. Hoffman, J. Granroth, and M. Castro A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis Chest 135 1 2009 48 56
39. A. ten Brinke, A. Zwinderman, P. Sterk, K. Rabe, and E. Bel Factors associated with persistent airflow limitation in severe asthma Am J Respir Crit Care Med 164 5 2001 744 748 (Pubitemid 32881907)
40. R. Louis, L. Lau, A. Bron, A. Roldaan, M. Radermecker, and R. Djukanović The relationship between airways inflammation and asthma severity Am J Respir Crit Care Med 161 1 2000 9 16 (Pubitemid 30055896)
41. A. ten Brinke, A. Zwinderman, P. Sterk, K. Rabe, and E. Bel "Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids Am J Respir Crit Care Med 170 6 2004 601 605 (Pubitemid 39202200)
42. P. Silkoff, A. Lent, A. Busacker, R. Katial, S. Balzar, and M. Strand Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma J Allergy Clin Immunol 116 6 2005 1249 1255 (Pubitemid 41740931)
43. J. Bousquet, J. Kiley, E.D. Bateman, G. Viegi, A.A. Cruz, and N. Khaltaev Prioritised research agenda for prevention and control of chronic respiratory diseases Eur Respir J 36 5 2010 995 1001