Benefits of low weekly doses of methotrexate in steroid-dependent asthmatic patients. A double-blind, randomized, placebo-controlled study

Respiratory Medicine

Volumn 100, Issue 3, 2006, Pages 411-419

  Comet, Ricard ^a   Domingo, Christian ^a   Larrosa, Marta ^a   Morón, Anisi ^a   Rué, Montserrat ^b   Amengual, Maria Jose ^c   Marín, Albert ^a  

^a Hospital Universitari Parc Taulí   (Spain)

^b C Agy Hlth Technol Assess Res   (Spain)

^c Laboratory Department   (Spain)

Author keywords

Bone metabolism; Methotrexate; Steroid sparing agents; Steroid dependent asthma

Indexed keywords

CORTICOSTEROID; METHOTREXATE; METHYLPREDNISOLONE; OSTEOCALCIN; PLACEBO; STEROID;

ADULT; AGED; ARTICLE; ASTHMA; BLOOD ANALYSIS; BONE DENSITOMETRY; BONE METABOLISM; BRONCHOSPASM; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; FORCED EXPIRATORY VOLUME; HUMAN; LOW DRUG DOSE; LUNG FUNCTION TEST; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; URINALYSIS;

ADULT; AGED; ASTHMA; BONE AND BONES; BRONCHODILATOR AGENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; METHOTREXATE; METHYLPREDNISOLONE; MIDDLE AGED; RESPIRATORY FUNCTION TESTS; STEROIDS;

EID: 32644435868     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2005.07.003     Document Type: Article

References (40)

1. A. Jaen A. Ferrer I. Ormaza M. Rue C. Domingo A. Marin Prevalence of chronic bronchitis, asthma and airflow limitation in an urban-industrial area of Catalonia Arch Bronconeumol 35 1999 122-128
2. International Consensus Report on diagnosis and treatment of asthma. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892. Publication number 92-3091, March 1992. Eur Respir J 1992; 5:601-41.
3. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. NHLBI/WHO workshop report, National Institutes of Health, National Heart, Lung and Blood Institute, NIH publication number 95-3659. http://www.ginasthma.com.
4. De Diego Damià A, Galdiz Iturri JB, Casan Clara P, Duce García F, López Viñas A, Cobos Barroso N, et al. Diagnosis and treatment of acute and chronic ast]hma. In: Caminero Luna J, Fernández Fau L, editors. SEPAR recommendations. Barcelona: Ediciones Doyma; 1998. p. 331-70 [in Spanish].
5. V. Plaza F.J. Alvarez P. Casan N. Cobos A. Lopez M.A. Llauger et. al. Spanish Guide to Asthma Management (GEMA) Arch Bronconeumol 39 Suppl. 5 2003 1-42 in Spanish http://www.gemasma.com
6. M.F. Mullarkey D.R. Webb N.E. Pardee Methotrexate in the treatment of steroid-dependent asthma Ann Allergy 56 1986 347-350
7. C. Domingo A. Ferrer M.D. Torremorell A. Jaen J.J. Such A. Marin Methotrexate as a steroid-sparing agent in bronchial asthma: Preliminary results Chest 106 Suppl. 1994 108
8. C. Domingo R. Comet M. Bosque A. Moron C. Monton Methotrexate efficiency for treatment of corticosteroid-dependent asthmatic patients Rev Clin Esp 199 1999 142-146
9. B.E. Nordin Diagnostic procedures in disorders of calcium metabolism Clin Endocrinol (Oxford) 8 1978 55-67
10. J. Roca J. Sanchis A. Agusti-Vidal F. Segarra A. Navajas R. Rodriguez-Roisin et. al. Spirometric reference values from a Mediterranean population Bull Eur Physiopathol Respir 22 1986 217-224
11. F.E. Karch L. Lassagna Towards the operational identification of adverse drug reactions Clin Pharmacol Ther 21 1977 247-254
12. H.S. Nelson D.L. Hamilos P.R. Corsello N.V. Levesque A.D. Buchmeier B.L. Bucher A double-blind study of troleandomycin and methylprednisolone in asthmatic subjects who require dalily corticosteroids Am Rev Respir Dis 147 1993 398-404
13. D.J. Evans P. Cullinan D.M. Geddes E.H. Walters P.W. Jones Cyclosporin as an oral corticosteroid sparing agent in stable asthma (Cochrane Review) The Cochrane Library Issue 4 2003 Wiley Chichester, UK
14. D.J. Evans P. Cullinan D.M. Geddes E.H. Walters P.W. Jones Gold as an oral corticosteroid sparing agent in stable asthma (Cochrane Review) The Cochrane Library Issue 4 2003 Wiley Chichester, UK
15. H. Davies L. Olson P. Gibson Methotrexate as a steroid sparing agent for asthma in adults (Cochrane Review) The Cochrane Library Issue 4 2003 Wiley Chichester, UK
16. W.B. Klaustermeyer D.J. Noritake F.K. Kwong Chrysotherapy in the treatment of corticosteroid-dependent asthma J Allergy Clin Immunol 79 1987 720-725
17. G. Nierop W.P. Gijzel E.H. Bell A.H. Zwinderman J.H. Dijkman Auranofin in the treatment of steroid-dependent asthma: A double blind study Thorax 47 1992 349-354
18. A.G. Alexander N.C. Barnes A.B. Kay Trial of cyclosporin in corticosteroid-dependent chronic severe asthma Lancet 339 1992 324-328
19. S. Lock N. Barnes A. Kay Cyclosporin A (CsA) as a corticosteroid sparing agent in corticosteroid dependent asthma Eur Respir J 7 Suppl. 18 1994 282
20. R.J. Shiner A.J. Nunn K.F. Chung D.M. Geddes Randomised, double-blind, placebo-controlled trial of methotrexate in steroid-dependent asthma Lancet 336 1990 137-140
21. M.F. Mullarkey B.A. Blumenstein W.P. Andrade G.A. Bailey I. Olason C.E. Wetzel Methotrexate in the treatment of corticosteroid-dependent asthma. A double-blind crossover study N Engl J Med 318 1988 603-607
22. M.F. Mullarkey J.K. Lammert B.A. Blumenstein Long-term methotrexate treatment in corticosteroid-dependent asthma Ann Intern Med 112 1990 577-581
23. J. Hedman P. Seideman F. Albertioni B. Stenius-Aarniala Controlled trial of methotrexate in patients with severe chronic asthma Eur J Clin Pharmacol 49 1996 347-349
24. S.C. Erzurum J.A. Leff J.E. Cochran L.M. Ackerson S.J. Szefler R.J. Martin et. al. Lack of benefit of methotrexate in severe, steroid-dependent asthma. A double-blind, placebo-controlled study Ann Intern Med 114 1991 353-360
25. P. Ruegsegger T.C. Medici M. Anliker Corticosteroid-induced bone loss: A longitudinal study of alternate day therapy in patients with bronchial asthma using quantitative computed tomography Eur J Clin Pharmacol 25 1983 615-620
26. Adachi JD, Bensen WG, Bell MJ. Corticosteroid induced osteoporosis: follow-up over 3 years. In: Christiansen C, Overgaad K, editors, Osteoporosis 1990(3). Proceedings of the third international symposium on osteoporosis, Copenhagen, Denmark, 1990. p. 1745-7.
27. L.M. Buckley E.S. Leib K.S. Cartularo P.M. Vacek S.M. Cooper Effects of low dose corticosteroids on the bone mineral density of patients with rheumatoid arthritis J Rheumatol 22 1995 1055-1059
28. S.D. Aaron R.E. Dales B. Pham Management of steroid-dependent asthma with methotrexate: A meta-analysis of randomized clinical trials Respir Med 92 1998 1059-1065
29. M.G. Marin Low-dose methotrexate spares steroid usage in steroid-dependent asthmatic patients: A meta-analysis Chest 112 1997 29-33
30. P. Garnero W. Shih E. Gineyts D. Karpf P. Delmas Comparison of new biochemical markers of bone turn-over in late postmenopausal osteoporotic women in response to alendronate treatment J Clin Endocrinol Metab 79 1994 1693-1700
31. J.P. Brown P.D. Delmas L. Malaval C. Edouard M.C. Chapuy P.J. Meunier Serum bone Gla-protein: A specific marker for bone formation in postmenopausal osteoporosis Lancet 1 1984 1091-1093
32. P.D. Delmas B. Demiaux L. Malaval M.C. Chapuy P.J. Meunier Osteocalcin (or bone gla-protein), a new biological marker for studying bone pathology Presse Med 15 1986 643-646
33. B.P. Lukert J.C. Higgins M.M. Stoskopf Serum osteocalcin is increased in patients with hyperthyroidism and decreased in patients receiving glucocorticoids J Clin Endocrinol Metab 62 1986 1056-1058
34. S.I. Girgis A. Nwokeji B.H. Shakur P.W. Ind R.J. Shiner The effect of the steroid-sparing response to low-dose methotrexate on bone metabolism in glucocorticoid-dependent asthmatics Clin Chin Acta 341 2004 157-163
35. F. Tascioglu C. Oner O. Armagan The effect of low-dose methotrexate on bone mineral density in patients with early rheumatoid arthritis Rheumatol Int 23 2003 231-235
36. O. Di Munno M. Mazzantini L. Sinigaglia G. Bianchi G. Minisola M. Muratore et. al. Effect of low dose methotrexate on bone density in women with rheumatoid arthritis: Results from a multicenter cross-sectional study J Rheumatol 31 2004 1305-1309
37. N.J. Minaur D. Kounali S. Vedi J.E. Compston J.N. Beresford A.K. Bahlla Methotrexate in the treatment of rheumatoid arthritis. In vivo effects on bone density Rheumatology 41 2002 741-749
38. L.M. Buckley E.S. Leib K.S. Cartlaro P.M. Vacek S.M. Cooper Effects of low dose methotrexate on the bone mineral density of patients with rheumatoid arthritis J Rheumatol 24 1997 1489-1494
39. Recommendations for the prevention and treatment of glucocorticoid induced osteoporosis: 2001 update. American College of Rheumatology Ad Hoc Committee on Glucocorticoid-Induced Osteoporosis. Arthrit Rheum 2001; 44:1496-1503.
40. 3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial Ann Intern Med 125 1996 961-968