Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis

Oncogene

Volumn 33, Issue 19, 2014, Pages 2540-2546

  Kennedy, C L ^a,c   Najdovska, M ^a   Tye, H ^a   McLeod, L ^a   Yu, L ^a   Jarnicki, A ^b   Bhathal, P S ^c   Putoczki, T ^b,d   Ernst, M ^b,d   Jenkins, B J ^a  

^a MONASH UNIVERSITY   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

gastric cancer; Mal TIRAP; MyD88; TLR2

Indexed keywords

ADAPTOR PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; TIR DOMAIN CONTAINING ADAPTOR PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER MODEL; CARCINOGENESIS; INFLAMMATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; STOMACH CANCER;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, INTERLEUKIN-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TOLL-LIKE RECEPTOR 2;

EID: 84900397337     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.205     Document Type: Article

References (29)

1. Milne AN, Carneiro F, O'Morain C, Offerhaus GJ. Nature meets nurture: molecular genetics of gastric cancer. Hum Genet 2009; 126: 615-628.
2. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001; 345: 784-789.
3. Tye H, Kennedy CL, Najdovska M, McLeod L, McCormack W, Hughes N et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell 2012; 22: 466-478.
4. Uno K, Kato K, Atsumi T, Suzuki T, Yoshitake J, Morita H et al. Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol 2007; 293: 1004-1012.
5. Hold G, Rabkin CS, Chow WH, Smith MG, Gammon MD, Risch HA et al. A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology 2007; 132: 905-912.
6. Tahara T, Arisawa T, Wang F, Shibata T, Nakamura M, Sakata M et al. Toll-like receptor 2-196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. Cancer Sci 2007; 98: 1790-1794.
7. Mandell L, Moran AP, Cocchiarella A, Houghton J, Taylor N, Fox JG et al. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun 2004; 72: 6446-6454.
8. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol 2010; 11: 373-384.
9. Hoebe K, Jiang Z, Tabeta K, Du X, Georgel P, Crozat K et al. Genetic analysis of innate immunity. Adv Immunol 2006; 91: 175-226.
10. Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 2002; 420: 324-329.
11. Santos-Sierra S, Deshmukh SD, Kalnitski J, Kü enzi P, Wymann MP, Golenbock DT et al. Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. EMBO J 2009; 28: 2018-2027.
12. Cole LE, Laird MH, Seekatz A, Santiago A, Jiang Z, Barry E et al. Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling. J Leukoc Biol 2010; 87: 275-281.
13. Kenny EF, Talbot S, Gong M, Golenbock DT, Bryant CE, O'Neill LA. MyD88 adaptorlike is not essential for TLR2 signaling and inhibits signaling by TLR3. J Immunol 2009; 183: 3642-3651.
14. Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N et al. Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol 2000; 1: 533-540.
15. Shen Y, Kawamura I, Nomura T, Tsuchiya K, Hara H, Dewamitta SR et al. Toll-like receptor 2-and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages. Infect Immun 2010; 78: 2857-2867.
16. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007; 317: 121-124.
17. Rakoff-Nahoum S, Medzhitov R. Regulation of spontaneous intestinal tumor-igenesis through the adaptor protein MyD88. Science 2007; 317: 124-127.
18. Uronis JM, Mühlbauer M, Herfarth HH, Rubinas TC, Jones GS, Jobin C. Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One 2009; 4: e6026.
19. Swann JB, Vesely M, Silva A, Sharkey J, Akira S, Schreiber RD et al. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci USA 2008; 105: 652-656.
20. Coste I, Le Corf K, Kfoury A, Hmitou I, Druillennec S, Hainaut P et al. Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation. J Clin Invest 2010; 120: 3663-3667.
21. Ernst M, Najdovska M, Grail D, Lundgren-May T, Buchert M, Tye H et al. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J Clin Invest 2008; 118: 1727-1738.
22. Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P et al. Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat Med 2005; 11: 845-852.
23. Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ et al. IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. J Immunol 2011; 186: 1199-1208.
24. Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med 2010; 207: 1625-1636.
25. Schiechl G, Bauer B, Fuss I, Lang SA, Moser C, Ruemmele P et al. Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+ CD11b(high)Gr1(low) macrophages. J Clin Invest 2011; 121: 1692-1708.
26. Hutchinson E. Tumour immunology: Differing roles for MYD88 in carcinogenesis. Nat Rev Immunol 2012; 12: 681.
27. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature 2012; 491: 254-258.
28. Kennedy CL, Najdovska M, Jones GW, McLeod L, Hughes NR, Allison C et al. The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17. J Pathol 2011; 225: 255-264.
29. Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 2009; 15: 91-102.