Polymorphism of Nrf2, an antioxidative gene, is associated with blood pressure and cardiovascular mortality in hemodialysis patients

International Journal of Medical Sciences

Volumn 11, Issue 7, 2014, Pages 726-731

  Shimoyama, Yasuhiko ^a   Mitsuda, Yoko ^a   Tsuruta, Yoshinari ^b   Hamajima, Nobuyuki ^a   Niwa, Toshimitsu ^a,c  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Meiyo Clinic   (Japan)

^c SHUBUN UNIVERSITY   (Japan)

Author keywords

Blood pressure; Cardiovascular mortality; Hemodialysis; Nrf2; Polymorphism

Indexed keywords

ALBUMIN; BETA 2 MICROGLOBULIN; TRANSCRIPTION FACTOR NRF2; NFE2L2 PROTEIN, HUMAN;

ADULT; AGE DISTRIBUTION; ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR MORTALITY; CONFRONTING TWO PAIR PRIMER ASSAY; CONTROLLED STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC PROCEDURES; GENOTYPE; HEMODIALYSIS PATIENT; HETEROZYGOTE; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; NRF2 GENE; POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; AGED; CARDIOVASCULAR DISEASE; GENETICS; MIDDLE AGED; MORTALITY; RENAL REPLACEMENT THERAPY;

AGED; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MIDDLE AGED; NF-E2-RELATED FACTOR 2; POLYMORPHISM, SINGLE NUCLEOTIDE; RENAL DIALYSIS;

EID: 84900396778     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.8590     Document Type: Article

References (25)

1. Kensle TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2007; 47: 89-106.
2. Dhakshinamoothy S, Jaiswal AK. Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Oncogene. 2001; 20: 3906-3917.
3. Itoh K, Wakabayashi N, Katoh Y, et al. Keap1 represses nuclear activation of anti-oxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999; 13: 76-86.
4. Chan K, Kan YW. Nrf2 is essential for protection against acute pulmonary in jury in mice. Proc Natl Acad Sci USA. 1999; 96: 12731-12736.
5. Cho HY, Jedlicka AE, Reddy SP, et al. Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol. 2002; 26: 175-182.
6. Cho HY, Reddy SP, Yamamoto M, et al. The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J. 2004; 18: 1258-1260.
7. Enomoto A, Itoh K, Nagayoshi E, et al. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity of Nrf2 knockout mice to acetaminophen hepatotoxi-city associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Taxicol Sci. 2001; 59: 169-177.
8. Murphy TH, De Long MJ, Coyle JT. Enhanced NAD(P)H:quinone reductase activity prevents glutamate toxicity produced by oxidative stress. J Neurochem. 1991; 56: 990-995.
9. Li J, Lee JM, Johnson JA. Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells. J Biol Chem. 2002; 277: 388-394.
10. Ruiz S, Pergola PE, Zager RA, et al. Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease. Kidney Int. 2013; 83: 1029-1041.
11. Levonen AL, Inkala M, Heikura T, et al. Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo. Arterioscler Thromb Vasc Biol. 2007; 27: 741-747.
12. Jyrkkanen HK, Kansanen E, Inkala M, et al. Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo. Circ Res. 2008; 103: e1-e9.
13. Yet SF, Layne MD, Liu X, et al. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J. 2003; 17: 1759-1761.
14. Lee JM, Li J, Johnson DA, Stein TD, et al. Nrf2, a multi-organ protector? FASEB J. 2005; 19: 1061-4.
15. Marzec JM, Christie JD, Reddy SP, et al. Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J. 2007; 21: 2237-2246.
16. Marczak ED, Marzec J, Zeldin DC, et al. Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans. Pharmacogenet Genomics. 2012; 22: 620-628.
17. Yamamoto T, Yoh K, Kobayashi A, et al. Identification of polymorphisms in the promoter region of the human NRF2 gene. Biochem Biophys Res Commun. 2004; 321: 72-79.
18. Siedlinski M, Postma DS, Boer JM, et al. Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population. Respir Res. 2009; 10: 73.
19. Córdova EJ, Velázquez-Cruz R, Centeno F, et al. The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus. Lupus. 2010; 19: 1237-1242.
20. Taki K, Takayama F, Tsuruta Y, et al. Oxidative stress, advanced glycation end product and coronary artery calcification in hemodialysis patients. Kidney Int. 2006; 70: 218-224.
21. Hamajima N, Saito T, Matsuo K, et al. Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping. Jpn J Cancer Res. 2000; 91: 865-868.
22. Heitzer T, Schlinzig T, Krohn K, et al. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation. 2001; 104: 2673-2678.
23. Wu L, Noyan Ashraf MH, Facci M, et al. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Proc Natl Acad Sci USA. 2004; 101: 7094-7099.
24. Sussan TE, Jun J, Thimmulappa R, et al. Disruption of Nrf2, a key inducer of antiox-idant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS One. 2008; 3: e3791.
25. Barajas B, Che N, Yin F, et al. NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection. Arterioscler Thromb Vasc Biol. 2011; 31: 58-66.