Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Stone, Amy E L ^a,b   Mitchell, Angela ^a,b   Brownell, Jessica ^c   Miklin, Daniel J ^b   Golden Mason, Lucy ^a,b   Polyak, Stephen J ^c   Gale Jr , Michael J ^c   Rosen, Hugo R ^a,b,d  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDE; CORE PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 7; PATTERN RECOGNITION RECEPTOR; STAT1 PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR AGONIST; VIRUS RNA; NUCLEOCAPSID PROTEIN, HEPATITIS C VIRUS; TOLL LIKE RECEPTOR;

ARTICLE; CELL DEATH; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEPATITIS C VIRUS; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE; INTERFERON INDUCTION; INTERFERON PRODUCTION; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL LINE; DENDRITIC CELL; DRUG EFFECTS; HUMAN; METABOLISM; SIGNAL TRANSDUCTION;

CELL DEATH; CELL LINE; CELL PROLIFERATION; DENDRITIC CELLS; HUMANS; INTERFERON REGULATORY FACTOR-7; INTERFERONS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTORS; VIRAL CORE PROTEINS;

EID: 84900385674     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095627     Document Type: Article

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