Both NK cell-intrinsic and -extrinsic STAT1 signaling are required for NK cell response against vaccinia virus

Journal of Immunology

Volumn 191, Issue 1, 2013, Pages 363-368

  Fortin, Carl ^a   Huang, Xiaopei ^a   Yang, Yiping ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; NATURAL KILLER CELL RECEPTOR NKG2D; NATURAL KILLER CELL RECEPTOR NKG2D LIGAND; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ACCESSORY CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DNA VIRUS INFECTION; FEMALE; IMMUNE RESPONSE; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; VACCINIA VIRUS; VIRAL CLEARANCE;

ANIMALS; CELL LINE; COCULTURE TECHNIQUES; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; FEMALE; IMMUNITY, INNATE; KILLER CELLS, NATURAL; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; VACCINIA; VACCINIA VIRUS;

EID: 84879655733     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202714     Document Type: Article

References (24)

1. Lee, S. H., T. Miyagi, and C. A. Biron. 2007. Keeping NK cells in highly regulated antiviral warfare. Trends Immunol. 28: 252-259. (Pubitemid 46810349)
2. Lanier, L. L. 2008. Up on the tightrope: natural killer cell activation and inhibition. Nat. Immunol. 9: 495-502. (Pubitemid 351560518)
3. Bukowski, J. F., B. A. Woda, S. Habu, K. Okumura, and R. M. Welsh. 1983. Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo. J. Immunol. 131: 1531-1538. (Pubitemid 13048919)
4. Natuk, R. J., and R. M. Welsh. 1987. Accumulation and chemotaxis of natural killer/large granular lymphocytes at sites of virus replication. J. Immunol. 138: 877-883. (Pubitemid 17012407)
5. Martinez, J., X. Huang, and Y. Yang. 2008. Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. J. Immunol. 180: 1592-1597.
6. Martinez, J., X. Huang, and Y. Yang. 2010. Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection. PLoS Pathog. 6: e1000811.
7. Fenner, F. H. D., I. Arita, Z. Jezek, and I. D. Ladnyi. 1988. Smallpox and Its Eradication . World Health Organization, Geneva.
8. Zhu, J., J. Martinez, X. Huang, and Y. Yang. 2007. Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta. Blood 109: 619-625. (Pubitemid 46105962)
9. Levy, D. E., and J. E. Darnell, Jr. 2002. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3: 651-662. (Pubitemid 34987786)
10. García-Sastre, A., and C. A. Biron. 2006. Type 1 interferons and the virus-host relationship: a lesson in détente. Science 312: 879-882.
11. Meraz, M. A., J. M. White, K. C. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, et al. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84: 431-442. (Pubitemid 26058568)
12. Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84: 443-450. (Pubitemid 26058569)
13. Lee, C. K., D. T. Rao, R. Gertner, R. Gimeno, A. B. Frey, and D. E. Levy. 2000. Distinct requirements for IFNs and STAT1 in NK cell function. J. Immunol. 165: 3571-3577. (Pubitemid 32057258)
14. Nguyen, K. B., T. P. Salazar-Mather, M. Y. Dalod, J. B. Van Deusen, X. Q. Wei, F. Y. Liew, M. A. Caligiuri, J. E. Durbin, and C. A. Biron. 2002. Coordinated and distinct roles for IFN-ab, IL-12, and IL-15 regulation of NK cell responses to viral infection. J. Immunol. 169: 4279-4287. (Pubitemid 35178200)
15. Fortin, C., X. Huang, and Y. Yang. 2012. NK cell response to vaccinia virus is regulated by myeloid-derived suppressor cells. J. Immunol. 189: 1843-1849.
16. Yang, Y., C. T. Huang, X. Huang, and D. M. Pardoll. 2004. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat. Immunol. 5: 508-515. (Pubitemid 38660463)
17. Andoniou, C. E., S. L. van Dommelen, V. Voigt, D. M. Andrews, G. Brizard, C. Asselin-Paturel, T. Delale, K. J. Stacey, G. Trinchieri, and M. A. Degli-Esposti. 2005. Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nat. Immunol. 6: 1011-1019. (Pubitemid 41486186)
18. Novy, P., X. Huang, W. J. Leonard, and Y. Yang. 2011. Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection. J. Immunol. 186: 2729-2738.
19. Newman, K. C., and E. M. Riley. 2007. Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens. Nat. Rev. Immunol. 7: 279-291. (Pubitemid 46480956)
20. Jinushi, M., T. Takehara, T. Tatsumi, T. Kanto, V. Groh, T. Spies, T. Suzuki, T. Miyagi, and N. Hayashi. 2003. Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection. J. Immunol. 171: 5423-5429. (Pubitemid 37432829)
21. Shresta, S., K. L. Sharar, D. M. Prigozhin, H. M. Snider, P. R. Beatty, and E. Harris. 2005. Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice. J. Immunol. 175: 3946-3954. (Pubitemid 41292056)
22. Brown, M. G., A. O. Dokun, J. W. Heusel, H. R. Smith, D. L. Beckman, E. A. Blattenberger, C. E. Dubbelde, L. R. Stone, A. A. Scalzo, and W. M. Yokoyama. 2001. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science 292: 934-937. (Pubitemid 32422491)
23. Mandelboim, O., N. Lieberman, M. Lev, L. Paul, T. I. Arnon, Y. Bushkin, D. M. Davis, J. L. Strominger, J. W. Yewdell, and A. Porgador. 2001. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature 409: 1055-1060. (Pubitemid 32204059)
24. Gumá, M., A. Angulo, and M. López-Botet. 2006. NK cell receptors involved in the response to human cytomegalovirus infection. Curr. Top. Microbiol. Immunol. 298: 207-223.