Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways

Hearing Research

Volumn 313, Issue , 2014, Pages 26-37

  Kalinec, Gilda M ^a   Thein, Pru ^a   Parsa, Arya ^a   Yorgason, Joshua ^b   Luxford, William ^c   Urrutia, Raul ^d   Kalinec, Federico ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c HOUSE CLINIC   (United States)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 2ALPHA; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; ANALGESIC AGENT; BENZOQUINONE DERIVATIVE; DDIT3 PROTEIN, MOUSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IMINE; INITIATION FACTOR 2; N-ACETYL-4-BENZOQUINONEIMINE;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; GENOMICS; HAIR CELL; IN VITRO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEOMICS; ANIMAL; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; METABOLISM; PATHOLOGY; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; TIME; TOXICITY;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BENZOQUINONES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HAIR CELLS, AUDITORY, OUTER; IMINES; MICE; OXIDATIVE STRESS; PROTEIN FOLDING; PROTEIN INTERACTION MAPPING; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTOR CHOP;

EID: 84900022147     PISSN: 03785955     EISSN: 18785891     Source Type: Journal    
DOI: 10.1016/j.heares.2014.04.007     Document Type: Article

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