Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 11, 2014, Pages 2424-2428

  More, Kunal N ^a   Jang, Hyo Weon ^b   Hong, Victor S ^a   Lee, Jinho ^a  

^a Keimyung University   (South Korea)

^b Sunchon National University   (South Korea)

Author keywords

3,5 Disubstituted indole; Antiproliferative activity; Inhibitor; Meridianin C; Pim kinase

Indexed keywords

ANTINEOPLASTIC AGENT; ATENOLOL; DOXORUBICIN; INDOLE DERIVATIVE; MERIDIANIN C DERIVATIVE; PROPRANOLOL; PROTEIN KINASE PIM; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; PROTEIN KINASE PIM 3; PROTEIN SERINE THREONINE KINASE; STAUROSPORINE; UNCLASSIFIED DRUG; ETHYLENEDIAMINE DERIVATIVE; N1-(6-(3-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOL-5-YL)PYRAZIN-2-YL)-N2,N2-DIMETHYLETHANE-1,2-DIAMINE; PROTEIN KINASE INHIBITOR; PROTO-ONCOGENE PROTEINS PIM;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CACO 2 CELL LINE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; JURKAT CELL LINE; K562 CELL LINE; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CACO-2 CELLS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ETHYLENEDIAMINES; HUMANS; INDOLES; JURKAT CELLS; K562 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-PIM-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899994327     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.035     Document Type: Article

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