Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design

Journal of Medicinal Chemistry

Volumn 55, Issue 6, 2012, Pages 2641-2648

  Good, Andrew C ^a   Liu, Jinyu ^a   Hirth, Bradford ^a   Asmussen, Gary ^a   Xiang, Yibin ^a   Biemann, Hans Peter ^a   Bishop, Kimberly A ^a   Fremgen, Trisha ^a   Fitzgerald, Maria ^a   Gladysheva, Tatiana ^a   Jain, Annuradha ^a   Jancsics, Katherine ^a   Metz, Markus ^a   Papoulis, Andrew ^a   Skerlj, Renato ^a   Stepp, J David ^a   Wei, Ronnie R ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; PROTEIN KINASE PIM 1; PROTEIN SERINE THREONINE KINASE INHIBITOR; THIAZOLE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; CULTURE OPTIMIZATION; DATA ANALYSIS; DRUG DESIGN; FRAGMENTATION REACTION; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR HYBRIDIZATION; NEEDLE; PROCESS OPTIMIZATION; SURFACE PLASMON RESONANCE;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-PIM-1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863343926     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2014698     Document Type: Article

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