Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis

Cell Reports

Volumn 7, Issue 3, 2014, Pages 871-882

  Zeng, Taoling ^a   Wang, Qun ^a   Fu, Jieying ^a   Lin, Qi ^a   Bi, Jing ^a   Ding, Weichao ^a   Qiao, Yikai ^a   Zhang, Sheng ^a   Zhao, Wenxiu ^a   Lin, Huayue ^a   Wang, Meilin ^a   Lu, Binfeng ^b   Deng, Xianming ^a   Zhou, Dawang ^a   Yin, Zhenyu ^a   Wang, Hong Rui ^a  

^a XIAMEN UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANOSINE TRIPHOSPHATASE; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAS PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE NEDD4; ESCRT PROTEIN; NEDD4 UBIQUITIN PROTEIN LIGASES; PROTEIN BINDING; UBIQUITIN PROTEIN LIGASE; H RAS PROTEIN; N RAS PROTEIN; PHOSPHATASE AND TENSIN HOMOLOG; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE NEDD4-1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL TRANSFORMATION; CONTROLLED STUDY; GENE MUTATION; HYDROLYSIS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTO ONCOGENE; UBIQUITINATION; 3T3 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; METABOLISM; NEOPLASM; NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UPREGULATION; XENOGRAFT; ANIMAL CELL; ANIMAL MODEL; BINDING AFFINITY; CLINICAL ARTICLE; COLON CARCINOGENESIS; COLORECTAL CANCER; CONFORMATIONAL TRANSITION; DOWN REGULATION; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN TARGETING;

ANIMALS; CARCINOGENESIS; CELL LINE, TUMOR; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; EPIDERMAL GROWTH FACTOR; HEK293 CELLS; HELA CELLS; HEP G2 CELLS; HUMANS; MICE; MICE, NUDE; NEOPLASMS; NIH 3T3 CELLS; PROTEIN BINDING; PTEN PHOSPHOHYDROLASE; RAS PROTEINS; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; UP-REGULATION;

EID: 84899976895     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.03.045     Document Type: Article

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