Prediction of methotrexate CNS distribution in different species - Influence of disease conditions

European Journal of Pharmaceutical Sciences

Volumn 57, Issue 1, 2014, Pages 11-24

  Westerhout, Joost ^a   Van Den Berg, Dirk Jan ^a   Hartman, Robin ^a   Danhof, Meindert ^a   De Lange, Elizabeth C M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Blood brain barrier; Brain extracellular fluid; Cerebrospinal fluid; Methotrexate; Pharmacokinetics; Systems based pharmacokinetic modeling

Indexed keywords

METHOTREXATE; PROBENECID; ANTINEOPLASTIC ANTIMETABOLITE; MULTIDRUG RESISTANCE PROTEIN; ORGANIC ANION TRANSPORTER;

ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN FOURTH VENTRICLE; CENTRAL NERVOUS SYSTEM; CISTERNA MAGNA; CONTROLLED STUDY; CORPUS STRIATUM; CREATININE CLEARANCE; DOG; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY CLEARANCE; LATERAL BRAIN VENTRICLE; LIVER BLOOD FLOW; LIVER CLEARANCE; LIVER WEIGHT; MALE; NONHUMAN; PASSIVE TRANSPORT; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; PLASMA PROTEIN BINDING; PREDICTION; PRIORITY JOURNAL; RAT; SUBARACHNOID SPACE; ADULT; AGE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; BLOOD; CEREBROSPINAL FLUID; CHILD; DISEASES; DRUG EFFECTS; METABOLISM; MICRODIALYSIS; REPRODUCIBILITY; SPECIES DIFFERENCE; SYSTEMS BIOLOGY; TISSUE DISTRIBUTION; WISTAR RAT;

ADULT; AGE FACTORS; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CENTRAL NERVOUS SYSTEM; CHILD; DISEASE; DOGS; HUMANS; MALE; METHOTREXATE; MICRODIALYSIS; MODELS, BIOLOGICAL; ORGANIC ANION TRANSPORTERS; P-GLYCOPROTEINS; PROBENECID; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SPECIES SPECIFICITY; SYSTEMS BIOLOGY; TISSUE DISTRIBUTION;

EID: 84899949318     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.12.020     Document Type: Article

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