Development of a sequential linked pharmacokinetic and pharmacodynamic simulation model for ivabradine in healthy volunteers

European Journal of Pharmaceutical Sciences

Volumn 10, Issue 4, 2000, Pages 275-284

  Duffull, Stephen B ^a   Aarons, Leon ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Healthy volunteers; Heart rate; Ivabradine; Modelling; NONMEM; Pharmacodynamics; Pharmacokinetics

Indexed keywords

INOTROPIC AGENT; IVABRADINE; NEW DRUG; PLACEBO; UNCLASSIFIED DRUG;

ANGINA PECTORIS; ARTICLE; COMPUTER PROGRAM; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; EXERCISE; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SIMULATION;

BENZAZEPINES; CARDIOTONIC AGENTS; EXERCISE TEST; HEART RATE; HUMANS; LINEAR MODELS; MALE; MODELS, BIOLOGICAL; MODELS, CHEMICAL;

EID: 0034031958     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00085-3     Document Type: Article

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