The adjuvant component α-tocopherol triggers via modulation of Nrf2 the expression and turnover of hypocretin in vitro and its implication to the development of narcolepsy

Vaccine

Volumn 32, Issue 25, 2014, Pages 2980-2988

  Masoudi, Sanita ^a   Ploen, Daniela ^a   Kunz, Katharina ^a   Hildt, Eberhard ^a,b  

^a PAUL EHRLICH INSTITUT   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Adjuvant; ASO3; Hypocretin; NF B; Nrf2; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OREXIN; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVE SITE; GENE EXPRESSION; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; HYPOTHALAMUS; IMMUNOMODULATION; IN VITRO STUDY; NARCOLEPSY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; REPORTER GENE; RETINA NERVE CELL;

ADJUVANT; ASO3; HYPOCRETIN; NF-ΚB; NRF2; Α-TOCOPHEROL;

ADJUVANTS, IMMUNOLOGIC; ALPHA-TOCOPHEROL; ANIMALS; CELL LINE, TUMOR; HLA-DQ BETA-CHAINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NARCOLEPSY; NEURONS; NEUROPEPTIDES; NF-E2-RELATED FACTOR 2; NF-KAPPA B; PROMOTER REGIONS, GENETIC; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 84899942687     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2014.03.085     Document Type: Article

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