Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replication

FEBS Letters

Volumn 580, Issue 2, 2006, Pages 575-580

  Burckstummer T ^a,d   Kriegs, M ^a   Lupberger, J ^a   Pauli, E K ^a   Schmittel, S ^a   Hildt, E ^a,b,c  

^a ROBERT KOCH INSTITUTE   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

HCV; NS5A; Raf 1; Replication

Indexed keywords

NONSTRUCTURAL PROTEIN 5; RAF PROTEIN; SERINE; SMALL INTERFERING RNA; SORAFENIB; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DOWN REGULATION; DRUG BINDING; DRUG MECHANISM; ENZYME INHIBITION; HEPATITIS C VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VIRUS REPLICATION;

ANIMALS; BENZENESULFONATES; HEPACIVIRUS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-RAF; PYRIDINES; REPLICON; RNA REPLICASE; RNA, SMALL INTERFERING; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 30644465541     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.12.071     Document Type: Article

References (23)

1. J.H. Hoofnagle Course and outcome of hepatitis C Hepatology 36 2002 S21 S29
2. M. Hijikata Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus Proc. Natl. Acad. Sci. USA 90 1993 10773 10777
3. V. Lohmann, F. Korner, J. Koch, U. Herian, L. Theilmann, and R. Bartenschlager Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line Science 285 1999 110 113
4. R. Gosert, D. Egger, V. Lohmann, R. Bartenschlager, H.E. Blum, K. Bienz, and D. Moradpour Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons J. Virol. 77 2003 5487 5492
5. K.J. Blight, A.A. Kolykhalov, and C.M. Rice Efficient initiation of HCV RNA replication in cell culture Science 290 2000 1972 1974
6. F. Penin Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A J. Biol. Chem. 2004
7. T.L. Tellinghuisen, and C.M. Rice Interaction between hepatitis C virus proteins and host cell factors Curr. Opin. Microbiol. 5 2002 419 427
8. S.L. Tan, H. Nakao, Y. He, S. Vijaysri, P. Neddermann, B.L. Jacobs, B.J. Mayer, and M.G. Katze NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling Proc. Natl. Acad. Sci. USA 96 1999 5533 5538
9. Y. He, H. Nakao, S.L. Tan, S.J. Polyak, P. Neddermann, S. Vijaysri, B.L. Jacobs, and M.G. Katze Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase J. Virol. 76 2002 9207 9217
10. M. Majumder, A.K. Ghosh, R. Steele, R. Ray, and R.B. Ray Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner J. Virol. 75 2001 1401 1407
11. L. Gao, H. Aizaki, J.W. He, and M.M. Lai Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft J. Virol. 78 2004 3480 3488
12. M. Frese, K. Barth, A. Kaul, V. Lohmann, V. Schwarzle, and R. Bartenschlager Hepatitis C virus RNA replication is resistant to tumour necrosis factor-alpha J. Gen. Virol. 84 2003 1253 1259
13. E. Hildt, and S. Oess Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I J. Exp. Med. 189 1999 1707 1714
14. E. Hildt, B. Munz, G. Saher, K. Reifenberg, and P.H. Hofschneider The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice Embo J. 21 2002 525 535
15. A. Macdonald, K. Crowder, A. Street, C. McCormick, K. Saksela, and M. Harris The hepatitis C virus nonstructural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling J. Biol. Chem. 278 2003 17775 17784
16. J.T. Bruder, G. Heidecker, and U.R. Rapp Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase Genes Dev. 6 1992 545 556
17. V. Brass, E. Bieck, R. Montserret, B. Wolk, J.A. Hellings, H.E. Blum, F. Penin, and D. Moradpour An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A J. Biol. Chem. 277 2002 8130 8139
18. E. O'Neill, and W. Kolch Conferring specificity on the ubiquitous Raf/MEK signalling pathway Br. J. Cancer 90 2004 283 288
19. M. Zang, C.A. Waelde, X. Xiang, A. Rana, R. Wen, and Z. Luo Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1 insights into mechanisms of Raf-1 activation J. Biol. Chem. 276 2001 25157 25165
20. P.T. Wan Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Cell 116 2004 855 867
21. J. Troppmair, and U.R. Rapp Raf and the road to cell survival: a tale of bad spells, ring bearers and detours Biochem. Pharmacol. 66 2003 1341 1345
22. S. Jin, Y. Zhuo, W. Guo, and J. Field PAK1-dependent phosphorylation of RAF-1 regulates its mitochondrial localization, phosphorylation of BAD, and BCL-2 association J. Biol. Chem. 2005
23. R.A. Hilger ERK1/2 phosphorylation: a biomarker analysis within a phase I study with the new Raf kinase inhibitor BAY43-9006 Int. J. Clin. Pharmacol. Ther. 40 2002 567 568