Reduced Insulin/IGF-1 Signaling Restores Germ Cell Immortality to Caenorhabditis elegans Piwi Mutants

Cell Reports

Volumn 7, Issue 3, 2014, Pages 762-773

  Simon, Matt ^a,b   Sarkies, Peter ^c   Ikegami, Kohta ^b,f   Doebley, Anna Lisa ^b   Goldstein, Leonard D ^c,d   Mitchell, Jacinth ^a,b   Sakaguchi, Aisa ^a,e   Miska, Eric A ^c   Ahmed, Shawn ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d GENENTECH INC   (United States)

^e GUNMA UNIVERSITY   (Japan)

^f PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; INSULIN; LYSINE; LYSINE 4; PIWI PROTEIN; SOMATOMEDIN; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG; ARGONAUTE PROTEIN; CAENORHABDITIS ELEGANS PROTEIN; DAF-16 PROTEIN, C ELEGANS; DAF-2 PROTEIN, C ELEGANS; INSULIN RECEPTOR; N DEMETHYLASE; PRG-1 PROTEIN, C ELEGANS; SMALL INTERFERING RNA; SOMATOMEDIN C; TRANSCRIPTION FACTOR; HISTONE DEMETHYLASE; INSULIN GROWTH FACTOR 1;

ARTICLE; CAENORHABDITIS ELEGANS; GENE EXPRESSION; GENE LOCUS; GERM CELL; LIFESPAN; LONGEVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; RNA INTERFERENCE; TRANSGENE; TRANSPOSON; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DEFICIENCY; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; CELL IMMORTALIZATION; CONTROLLED STUDY; DAF 2 GENE; FUNGAL GENE; FUNGAL STRAIN; GENE FUNCTION; GENE MUTATION; GENE SILENCING; GENOME; PRG 1 GENE;

ANIMALS; ARGONAUTE PROTEINS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GERM CELLS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; OXIDOREDUCTASES, N-DEMETHYLATING; RECEPTOR, INSULIN; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

CAENORHABDITIS ELEGANS;

EID: 84899938106     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.03.056     Document Type: Article

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