Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 3, 2014, Pages 949-953

  Gillespie, Paul ^a   Goodnow, Robert A ^a   Saha, Goutam ^b   Bose, Gopal ^b   Moulik, Kakali ^b   Zwingelstein, Catherine ^a   Myers, Michael ^a   Conde Knape, Karin ^a   Pietranico Cole, Sherrie ^a   So, Sung Sau ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b Molecular Modeling Section   (India)

Author keywords

Agonist; GPCR; GPR119; Oral glucose tolerance test; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; BENZENE DERIVATIVE; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119; GLUCOSE; POTASSIUM CHANNEL HERG; PYRAZOLO[3,4 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; DRUG CLEARANCE; DRUG DESIGN; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; ELECTRON; ELECTRON TRANSPORT; ENZYME INHIBITION; IC 50; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; STRUCTURE ACTIVITY RELATION;

MUS;

AGONIST; GPCR; GPR119; ORAL GLUCOSE TOLERANCE TEST; TYPE 2 DIABETES;

ANIMALS; DRUG DISCOVERY; HUMANS; MICE; PYRAZOLES; PYRIMIDINES; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893705388     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.12.063     Document Type: Article

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