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Volumn 20, Issue 7, 2012, Pages 2369-2375
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Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists
a
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Author keywords
G protein coupled receptor 119; Glucose dependent insulin secretion; GPR119 agonist; Type 2 diabetes mellitus
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Indexed keywords
2 (4 BROMOPHENYL) 4 CHLORO 6 METHYLPYRIMIDINE;
2 (4 BROMOPHENYL) 6 DIFLUOROMETHYLPYRIMIDIN 4 ONE;
2 (4 BROMOPHENYL) 6 ETHYLPYRIMIDIN 4 ONE;
2 (4 BROMOPHENYL) 6 ISOPROPYLPYRIMIDIN 4 ONE;
2 (4 BROMOPHENYL) 6 METHYL N [2 (1 OXIDOPYRIDIN 3 YL)ETHYL]PYRIMIDIN 4 AMINE OXALATE;
2 (4 BROMOPHENYL) 6 METHYL N [2 (PYRIDIN 3 YL)ETHYL]PYRIMIDIN 4 AMINE OXALATE;
2 (4 BROMOPHENYL) 6 METHYLPYRIMIDIN 4 ONE;
2 (4 BROMOPHENYL) 6 PROPYLPYRIMIDIN 4 ONE;
2 (4 BROMOPHENYL) 6 PYRIMIDIN 4 ONE;
2 (4 BROMOPHENYL) 6 TRIFLUOROMETHYLPYRIMIDIN 4 ONE;
2 (4 BROMOPHENYL) N (2 METHOXYETHYL) 6 METHYLPYRIMIDIN 4 AMINE OXALATE;
2 (4 BROMOPHENYL) N ISOBUTYL 6 METHYLPYRIMIDIN 4 AMINE OXALATE;
2 (4 CHLOROPHENYL) 6 METHYLPYRIMIDIN 4 ONE;
2 (4 IODOPHENYL) 6 METHYLPYRIMIDIN 4 ONE;
2 (4 METHOXYPHENYL) 6 METHYLPYRIMIDIN 4 ONE;
2 [[2 (4 BROMOPHENYL) 6 METHYLPYRIMIDIN 4 YL]AMINO]ETHANOL;
4 AMINO 2 PHENYLPYRIMIDINE DERIVATIVE;
4 BROMOBENZAMIDINE;
4 CHLORO 2 (4 CHLOROPHENYL) 6 METHYLPYRIMIDINE;
4 CHLORO 2 (4 IODOPHENYL) 6 METHYLPYRIMIDINE;
4 CHLORO 6 METHYL 2 PHENYLPYRIMIDINE;
6 METHYL 2 (4 METHYLPHENYL)PYRIMIDIN 4 ONE;
6 METHYL 2 PHENYLPYRIMIDIN 4 ONE;
CYTOCHROME P450 1A2;
G PROTEIN COUPLED RECEPTOR;
G PROTEIN COUPLED RECEPTOR 119;
GLUCOSE;
PLACEBO;
PROTEIN DERIVATIVE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANTIDIABETIC ACTIVITY;
ARTICLE;
CHEMICAL MODIFICATION;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
DISTRIBUTION VOLUME;
DRUG ABSORPTION;
DRUG BIOAVAILABILITY;
DRUG CLEARANCE;
DRUG HALF LIFE;
DRUG IDENTIFICATION;
DRUG POTENCY;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME INHIBITION;
GENETIC TRANSFECTION;
GLUCOSE BLOOD LEVEL;
GLUCOSE TOLERANCE;
GLUCOSE TOLERANCE TEST;
HUMAN;
HUMAN CELL;
HYDROGEN BOND;
IC 50;
IN VITRO STUDY;
IN VIVO STUDY;
MALE;
NONHUMAN;
ORAL GLUCOSE TOLERANCE TEST;
OXIDATION;
PROTEIN EXPRESSION;
RAT;
STRUCTURE ACTIVITY RELATION;
SUBSTITUTION REACTION;
ADMINISTRATION, ORAL;
ANIMALS;
CYCLIC N-OXIDES;
HEK293 CELLS;
HUMANS;
MALE;
MICE;
MICE, INBRED ICR;
PYRIDINES;
PYRIMIDINES;
RATS;
RECEPTORS, G-PROTEIN-COUPLED;
STRUCTURE-ACTIVITY RELATIONSHIP;
MUS;
RATTUS;
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EID: 84858285259
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2012.02.006 Document Type: Article |
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Times cited : (20)
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References (17)
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