Electrospinning of polymeric nanofibers for drug delivery applications

Journal of Controlled Release

Volumn 185, Issue 1, 2014, Pages 12-21

  Hu, Xiuli ^a   Liu, Shi ^a,b   Zhou, Guangyuan ^a   Huang, Yubin ^a   Xie, Zhigang ^a   Jing, Xiabin ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Drug delivery; Electrospinning; Local chemotherapy; Wound dressing

Indexed keywords

CHEMOTHERAPY; DRUG DELIVERY; ELECTROSPINNING; HYBRID MATERIALS; NANOFIBERS; NATURAL POLYMERS; NUCLEIC ACIDS; POLYMERS;

DRUG DELIVERY APPLICATIONS; ELECTROSPINNING TECHNIQUES; ELECTROSPUN FIBERS; HIGH SURFACE-TO-VOLUME RATIO; POLYMER NANOFIBERS; POLYMERIC NANOFIBERS; TRANSFER PROPERTIES; WOUND DRESSINGS;

LOADING;

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; DNA; GROWTH FACTOR; NANOFIBER; RNA; DRUG; POLYMER;

ANTIBIOTIC THERAPY; CANCER CHEMOTHERAPY; CELL ADHESION; DRUG DELIVERY SYSTEM; DRUG RELEASE; ELECTROSPINNING; HUMAN; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; REVIEW; SYRINGE; ANIMAL; BANDAGE; CHEMISTRY; DEVICES; ELECTROCHEMICAL ANALYSIS; EQUIPMENT DESIGN; PROCEDURES; ULTRASTRUCTURE;

ANIMALS; BANDAGES; DRUG DELIVERY SYSTEMS; ELECTROCHEMICAL TECHNIQUES; EQUIPMENT DESIGN; HUMANS; NANOFIBERS; PHARMACEUTICAL PREPARATIONS; POLYMERS;

EID: 84899879000     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.04.018     Document Type: Review

References (113)

1. A. Furmhals, US patent 1,975,504, 1934.
2. Z.M. Huang, Y.Z. Zhang, M. Kotaki, and S. Ramakrishna A review on polymer nanofibers by electrospinning and their applications in nanocomposites Compos. Sci. Technol. 63 2003 2223 2253
3. R. Gopal, S. Kaur, Z. Ma, C. Chan, S. Ramakrishna, and T. Matsuura Electrospun nanofibrous filtration membrane J. Membr. Sci. 281 2006 581 586
4. D. Aussawasathien, C. Teerawattananon, and A. Vongachariya Separation of micron to sub-micron particles from water: electrospun nylon-6 nanofibrous membranes as pre-filters J. Membr. Sci. 315 2008 11 19
5. H. Schreuder-Gibson, P. Gibson, K. Senecal, M. Sennett, J. Walker, W. Yeomans, D. Ziegler, and P.P. Tsai Protective textile materials based on electrospun nanofibers J. Adv. Mater. 34 2002 44 55
6. Z. Gu, Q. Xu, Cosmetic mask based on electrospinning nanometer fiber for skin, comprises electrospinning nanometer fiber nonwoven fabric or nonwoven felt, CN101390814-A.
7. N. Kusamoto, T. Tajima, Fiber comprises an eggshell membrane component useful for producing a fiber assembly, which is used as a wound dressing or a cosmetic sheet. US patent, US2009031691-A1.
8. S.E. Chung, C.H. Park, Manufacture of shape memory polyurethane electrospun web for e.g. protective clothing, involves electrospinning solution obtained by adding poly(caprolactone diol), diphenylmethane diisocyanate and butanediol to polyurethane, US patent KR2010048661-A.
9. S. Lee, and S.K. Obendorf Developing protective textile materials as barriers to liquid penetration using melt-electrospinning J. Appl. Polym. Sci. 102 2006 3430 3437
10. M. Gorji, A.A.A. Jeddi, and A.A. Gharehaghaji Fabrication and characterization of polyurethane electrospun nanofiber membranes for protective clothing applications J. Appl. Polym. Sci. 125 2012 4135 4141
11. R. Rojas, and N.J. Pinto Using electrospinning for the fabrication of rapid response gas sensors based on conducting polymer nanowires IEEE Sens. J. 8 2008 951 953
12. T. Kowalczyk, A. Nowicka, D. Elbaum, and T.A. Kowalewski Electrospinning of bovine serum albumin. Optimization and the use for production of biosensors Biomacromolecules 9 2008 2087 2090
13. Z. Dong, S.J. Kennedy, and Y. Wu Electrospinning materials for energy-related applications and devices J. Power Sources 196 2011 4886 4904
14. P. Zahedi, I. Rezaeian, S.-O. Ranaei-Siadat, S.-H. Jafari, and P. Supaphol A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages Polym. Adv. Technol. 21 2010 77 95
15. M.S. Khil, D.I. Cha, H.Y. Kim, I.S. Kim, and N. Bhattarai Electrospun nanofibrous polyurethane membrane as wound dressing J. Biomed. Mater. Res. B. 67B 2003 675 679
16. K.A. Rieger, N.P. Birch, and J.D. Schiffman Designing electrospun nanofiber mats to promote wound healing - a review J. Mater. Chem. B. 1 2013 4531 4541
17. V. Pillay, C. Dott, Y.E. Choonara, C. Tyagi, L. Tomar, P. Kumar, L.C. du Toit, and V.M.K. Ndesendo A review of the effect of processing variables on the fabrication of electrospun nanofibers for drug delivery applications J. Nanomater. 2013 1 22
18. T.J. Sill, and H.A. von Recum Electro spinning: applications in drug delivery and tissue engineering Biomaterials 29 2008 1989 2006
19. T. Lu, X. Chen, Q. Shi, Y. Wang, P. Zhang, and X. Jing The immobilization of proteins on biodegradable fibers via biotin-streptavidin bridges Acta Biomater. 4 2008 1770 1777
20. Q. Shi, X. Chen, T. Lu, and X. Jing The immobilization of proteins on biodegradable polymer fibers via click chemistry Biomaterials 29 2008 1118 1126
21. Q.P. Pham, U. Sharma, and A.G. Mikos Electrospinning of polymeric nanofibers for tissue engineering applications: a review Tissue Eng. 12 2006 1197 1211
22. H.S. Yoo, T.G. Kim, and T.G. Park Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery Adv. Drug Deliv. Rev. 61 2009 1033 1042
23. B. Wang, Y. Wang, T. Yin, and Q. Yu Applications of electrospinning technique in drug delivery Chem. Eng. Commun. 197 2010 1315 1338
24. S. Chakraborty, I.C. Liao, A. Adler, and K.W. Leong Electrohydrodynamics: a facile technique to fabricate drug delivery systems Adv. Drug Deliv. Rev. 61 2009 1043 1054
25. S. Liu, G. Zhou, D. Liu, Z. Xie, Y. Huang, X. Wang, W. Wu, and X. Jing Inhibition of orthotopic secondary hepatic carcinoma in mice by doxorubicin-loaded electrospun polylactide nanofibers J. Mater. Chem. B. 1 2013 101 109
26. M. Zamani, M.P. Prabhakaran, and S. Ramakrishna Advances in drug delivery via electrospun and electrosprayed nanomaterials Int. J. Nanomed. 8 2013 2997 3017
27. E.R. Kenawy, G.L. Bowlin, K. Mansfield, J. Layman, D.G. Simpson, E.H. Sanders, and G.E. Wnek Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend J. Control. Release 81 2002 57 64
28. M. Prabaharan, R. Jayakumar, and S.V. Nair Electrospun nanofibrous scaffolds - current status and prospects in drug delivery Adv. Polym. Sci. 246 2012 241 262
29. Y.Z. Zhang, C.T. Lim, S. Ramakrishna, and Z.M. Huang Recent development of polymer nanofibers for biomedical and biotechnological applications J. Mater. Sci. - Mater. M. 16 2005 933 946
30. G. Taylor Electrically driven jets Proc. R. Soc. Lond. A 313 1969 453 475
31. J. Zeng, X. Xu, X. Chen, Q. Liang, X. Bian, L. Yang, and X. Jing Biodegradable electrospun fibers for drug delivery J. Control. Release 92 2003 227 231
32. J.M. Deitzel, J. Kleinmeyer, D. Harris, and N.C.B. Tan The effect of processing variables on the morphology of electrospun nanofibers and textiles Polymer 42 2001 261 272
33. X.H. Zong, K. Kim, D.F. Fang, S.F. Ran, B.S. Hsiao, and B. Chu Structure and process relationship of electrospun bioabsorbable nanofiber membranes Polymer 43 2002 4403 4412
34. S. Megelski, J.S. Stephens, D.B. Chase, and J.F. Rabolt Micro- and nanostructured surface morphology on electrospun polymer fibers Macromolecules 35 2002 8456 8466
35. T. Uyar, and F. Besenbacher Electrospinning of uniform polystyrene fibers: the effect of solvent conductivity Polymer 49 2008 5336 5343
36. N. Bhardwaj, and S.C. Kundu Electrospinning: a fascinating fiber fabrication technique Biotechnol. Adv. 28 2010 325 347
37. H. Fong, I. Chun, and D.H. Reneker Beaded nanofibers formed during electrospinning Polymer 40 1999 4585 4592
38. C.L. Casper, J.S. Stephens, N.G. Tassi, D.B. Chase, and J.F. Rabolt Controlling surface morphology of electrospun polystyrene fibers: effect of humidity and molecular weight in the electrospinning process Macromolecules 37 2004 573 578
39. Y.X. Zhou, M. Freitag, J. Hone, C. Staii, A.T. Johnson, N.J. Pinto, and A.G. MacDiarmid Fabrication and electrical characterization of polyaniline-based nanofibers with diameter below 30 nm Appl. Phys. Lett. 83 2003 3800 3802
40. P. Gupta, and G.L. Wilkes Some investigations on the fiber formation by utilizing a side-by-side bicomponent electrospinning approach Polymer 44 2003 6353 6359
41. D.F. Fang, B. Chu, and B. Hsiao Multiple-jet electrospinning of non-woven nanofiber articles Abstr. Pap. Am. Chem. Soc. 226 2003 U424-U424
42. L. Persano, A. Camposeo, C. Tekmen, and D. Pisignano Industrial upscaling of electrospinning and applications of polymer nanofibers: a review Macromol. Mater. Eng. 298 2013 504 520
43. B. Ding, E. Kimura, T. Sato, S. Fujita, and S. Shiratori Fabrication of blend biodegradable nanofibrous nonwoven mats via multi-jet electrospinning Polymer 45 2004 1895 1902
44. I.G. Loscertales, A. Barrero, I. Guerrero, R. Cortijo, M. Marquez, and A.M. Ganan-Calvo Micro/nano encapsulation via electrified coaxial liquid jets Science 295 2002 1695 1698
45. Z.C. Sun, E. Zussman, A.L. Yarin, J.H. Wendorff, and A. Greiner Compound core-shell polymer nanofibers by co-electrospinning Adv. Mater. 15 2003 1929 1932
46. D. Li, and Y.N. Xia Fabrication of titania nanofibers by electrospinning Nano Lett. 3 2003 555 560
47. D. Li, and Y.N. Xia Electrospinning of nanofibers: reinventing the wheel? Adv. Mater. 16 2004 1151 1170
48. J.T. McCann, D. Li, and Y.N. Xia Electrospinning of nanofibers with core-sheath, hollow, or porous structures J. Mater. Chem. 15 2005 735 738
49. D. Li, and Y.N. Xia Direct fabrication of composite and ceramic hollow nanofibers by electrospinning Nano Lett. 4 2004 933 938
50. X.L. Xu, L.X. Yang, X.Y. Xu, X. Wang, X.S. Chen, Q.Z. Liang, J. Zeng, and X.B. Jing Ultrafine medicated fibers electrospun from W/O emulsions J. Control. Release 108 2005 33 42
51. Y. Yang, X. Li, M. Qi, S. Zhou, and J. Weng Release pattern and structural integrity of lysozyme encapsulated in core-sheath structured poly(dl-lactide) ultrafine fibers prepared by emulsion electrospinning Eur. J. Pharm. Biopharm. 69 2008 106 116
52. X. Xu, X. Chen, P.a. Ma, X. Wang, and X. Jing The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion- electrospinning Eur. J. Pharm. Biopharm. 70 2008 165 170
53. X. Xu, X. Zhuang, X. Chen, X. Wang, L. Yang, and X. Jing Preparation of core-sheath composite nanofibers by emulsion electrospinning Macromol. Rapid Commun. 27 2006 1637 1642
54. H. Qi, P. Hu, J. Xu, and A. Wang Encapsulation of drug reservoirs in fibers by emulsion electrospinning: morphology characterization and preliminary release assessment Biomacromolecules 7 2006 2327 2330
55. X. Xu, X. Zhuang, X. Chen, X. Wang, L. Yang, and X. Jing Preparation of core-sheath composite nanofibers by emulsion electrospinning Macromol. Rapid Commun. 27 2006 1637 1642
56. A.V. Bazilevsky, A.L. Yarin, and C.M. Megaridis Co-electrospinning of core-shell fibers using a single-nozzle technique Langmuir 23 2007 2311 2314
57. A. Theron, E. Zussman, and A.L. Yarin Electrostatic field-assisted alignment of electrospun nanofibres Nanotechnology 12 2001 384 390
58. D. Li, Y.L. Wang, and Y.N. Xia Electrospinning of polymeric and ceramic nanofibers as uniaxially aligned arrays Nano Lett. 3 2003 1167 1171
59. X. Wang, B. Ding, and B. Li Biomimetic electrospun nanofibrous structures for tissue engineering Mater. Today 16 2013 229 241
60. L. Kong, and G.R. Ziegler Fabrication of pure starch fibers by electrospinning Food Hydrocoll. 36 2014 20 25
61. H.K. Noh, S.W. Lee, J.M. Kim, J.E. Oh, K.H. Kim, C.P. Chung, S.C. Choi, W.H. Park, and B.M. Min Electrospinning of chitin nanofibers: degradation behavior and cellular response to normal human keratinocytes and fibroblasts Biomaterials 27 2006 3934 3944
62. J.D. Schiffman, and C.L. Schauer A review: electrospinning of biopolymer nanofibers and their applications Polym. Rev. 48 2008 317 352
63. V.Y. Chakrapani, A. Gnanamani, V.R. Giridev, M. Madhusoothanan, and G. Sekaran Electrospinning of type I collagen and PCL nanofibers using acetic acid J. Appl. Polym. Sci. 125 2012 3221 3227
64. Y. Su, X. Li, S. Liu, H. Wang, and C. He Fabrication and properties of PLLA-gelatin nanofibers by electrospinning J. Appl. Polym. Sci. 117 2010 542 547
65. T. Lu, X. Jing, X. Song, and X. Wang Doxorubicin-loaded ultrafine PEG-PLA fiber mats against hepatocarcinoma J. Appl. Polym. Sci. 123 2012 209 217
66. J. Xie, and C.-H. Wang Electrospun micro- and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro Pharm. Res. 23 2006 1817 1826
67. J. Xie, R.S. Tan, and C.-H. Wang Biodegradable microparticles and fiber fabrics for sustained delivery of cisplatin to treat C6 glioma in vitro J. Biomed. Mater. Res. A. 85A 2008 897 908
68. S.E. Gilchrist, D. Lange, K. Letchford, H. Bach, L. Fazli, and H.M. Burt Fusidic acid and rifampicin co-loaded PLGA nanofibers for the prevention of orthopedic implant associated infections J. Control. Release 170 2013 64 73
69. Y. Hong, K. Fujimoto, R. Hashizume, J. Guan, J.J. Stankus, K. Tobita, and W.R. Wagner Generating elastic, biodegradable polyurethane/poly(lactide-co- glycolide) fibrous sheets with controlled antibiotic release via two-stream electrospinning Biomacromolecules 9 2008 1200 1207
70. S.Y. Chew, J. Wen, E.K.F. Yim, and K.W. Leong Sustained release of proteins from electrospun biodegradable fibers Biomacromolecules 6 2005 2017 2024
71. X. Li, Y. Su, S. Liu, L. Tan, X. Mo, and S. Ramakrishna Encapsulation of proteins in poly(l-lactide-co-caprolactone) fibers by emulsion electrospinning Colloid. Surf. B. 75 2010 418 424
72. S.Y. Chew, R. Mi, A. Hoke, and K.W. Leong Aligned protein-polymer composite fibers enhance nerve regeneration: a potential tissue-engineering platform Adv. Funct. Mater. 17 2007 1288 1296
73. L. De Laporte, and L.D. Shea Matrices and scaffolds for DNA delivery in tissue engineering Adv. Drug Deliv. Rev. 59 2007 292 307
74. Y.K. Luu, K. Kim, B.S. Hsiao, B. Chu, and M. Hadjiargyrou Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers J. Control. Release 89 2003 341 353
75. H. Cao, X. Jiang, C. Chai, and S.Y. Chew RNA interference by nanofiber-based siRNA delivery system J. Control. Release 144 2010 203 212
76. P.-o. Rujitanaroj, Y.-C. Wang, J. Wang, and S.Y. Chew Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications Biomaterials 32 2011 5915 5923
77. Y. Wu, J.A. MacKay, J.R. McDaniel, A. Chilkoti, and R.L. Clark Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying Biomacromolecules 10 2009 19 24
78. K.Y. Lee, L. Jeong, Y.O. Kang, S.J. Lee, and W.H. Park Electrospinning of polysaccharides for regenerative medicine Adv. Drug Deliv. Rev. 61 2009 1020 1032
79. R. Toshkova, N. Manolova, E. Gardeva, M. Ignatova, L. Yossifova, I. Rashkov, and M. Alexandrov Antitumor activity of quaternized chitosan-based electrospun implants against Graffi myeloid tumor Int. J. Pharm. 400 2010 221 233
80. J. Du, E. Tan, H.J. Kim, A. Zhang, R. Bhattacharya, and K.J. Yarema Comparative evaluation of chitosan, cellulose acetate, and polyethersulfone nanofiber scaffolds for neural differentiation Carbohydr. Polym. 99 2014 483 490
81. K. Kim, M. Yu, X.H. Zong, J. Chiu, D.F. Fang, Y.S. Seo, B.S. Hsiao, B. Chu, and M. Hadjiargyrou Control of degradation rate and hydrophilicity in electrospun non-woven poly(d, l-lactide) nanofiber scaffolds for biomedical applications Biomaterials 24 2003 4977 4985
82. X.H. Zong, S.F. Ran, D.F. Fang, B.S. Hsiao, and B. Chu Control of structure, morphology and property in electrospun poly (glycolide-co-lactide) non-woven membranes via post-draw treatments Polymer 44 2003 4959 4967
83. J. Stitzel, L. Liu, S.J. Lee, M. Komura, J. Berry, S. Soker, G. Lim, M. Van Dyke, R. Czerw, J.J. Yoo, and A. Atala Controlled fabrication of a biological vascular substitute Biomaterials 27 2006 1088 1094
84. K.E. Park, H.K. Kang, S.J. Lee, B.M. Min, and W.H. Park Biomimetic nanofibrous scaffolds: preparation and characterization of PGA/chitin blend nanofibers Biomacromolecules 7 2006 635 643
85. Y.-F. Goh, I. Shakir, and R. Hussain Electrospun fibers for tissue engineering, drug delivery, and wound dressing J. Mater. Sci. 48 2013 3027 3054
86. D. Grafahrend, K.-H. Heffels, M.V. Beer, P. Gasteier, M. Moeller, and G. Boehm et al. Degradable polyester scaffolds with controlled surface chemistry combining minimal protein adsorption with specific bioactivation Nat. Mater. 10 2011 67 73
87. A. Lancuski, S. Fort, and F. Bossard Electrospun azido-PCL nanofibers for enhanced surface functionalization by click chemistry ACS Appl. Mater. Interfaces 4 2012 6499 6504
88. P. Zahedi, Z. Karami, I. Rezaeian, S.H. Jafari, P. Mahdaviani, and A.H. Abdolghaffari Preparation and performance evaluation of tetracycline hydrochloride loaded wound dressing mats based on electrospun nanofibrous poly(lactic acid)/poly(ε-caprolactone) blends J. Appl. Polym. Sci. 124 2012 4174 4183
89. M. Ignatova, I. Rashkov, and N. Manolova Drug-loaded electrospun materials in wound-dressing applications and in local cancer treatment Expert Opin. Drug Del. 10 2013 469 483
90. X. Xu, X. Chen, Z. Wang, and X. Jing Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity Eur. J. Pharm. Biopharm. 72 2009 18 25
91. A. Saraf, L.S. Baggett, R.M. Raphael, F.K. Kasper, and A.G. Mikos Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds J. Control. Release 143 2010 95 103
92. A. Mickova, M. Buzgo, O. Benada, M. Rampichova, Z. Fisar, E. Filova, M. Tesarova, D. Lukas, and E. Amler Core/shell nanofibers with embedded liposomes as a drug delivery system Biomacromolecules 13 2012 952 962
93. R. Dave, P. Jayaraj, P.K. Ajikumar, H. Joshi, T. Mathews, and V.P. Venugopalan Endogenously triggered electrospun fibres for tailored and controlled antibiotic release J. Biomat. Sci.-Polym. E. 24 2013 1305 1319
94. K. Kim, Y.K. Luu, C. Chang, D.F. Fang, B.S. Hsiao, B. Chu, and M. Hadjiargyrou Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds J. Control. Release 98 2004 47 56
95. S.T. Yohe, Y.L. Colson, and M.W. Grinstaff Superhydrophobic materials for tunable drug release: using displacement of air to control delivery rates J. Am. Chem. Soc. 134 2012 2016 2019
96. S.T. Yohe, V.L.M. Herrera, Y.L. Colson, and M.W. Grinstaff 3D superhydrophobic electrospun meshes as reinforcement materials for sustained local drug delivery against colorectal cancer cells J. Control. Release 162 2012 92 101
97. H.L. Jiang, D.F. Fang, B.J. Hsiao, B.J. Chu, and W.L. Chen Preparation and characterization of ibuprofen-loaded poly(lactide-co-glycolide)/ poly(ethylene glycol)-g-chitosan electrospun membranes J. Biomater. Sci. Polym. E. 15 2004 279 296
98. J. Zou, Y. Yang, Y. Liu, F. Chen, and X. Li Release kinetics and cellular profiles for bFGF-loaded electrospun fibers: effect of the conjugation density and molecular weight of heparin Polymer 52 2011 3357 3367
99. Y.Z. Zhang, X. Wang, Y. Feng, J. Li, C.T. Lim, and S. Ramakrishna Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(epsilon-caprolactone) nanofibers for sustained release Biomacromolecules 7 2006 1049 1057
100. S.S. Choi, J.P. Hong, Y.S. Seo, S.M. Chung, and C. Nah Fabrication and characterization of electrospun polybutadiene fibers crosslinked by UV irradiation J. Appl. Polym. Sci. 101 2006 2333 2337
101. W.-H. Lin, and W.-B. Tsai In situ UV-crosslinking gelatin electrospun fibers for tissue engineering applications Biofabrication 5 2013
102. J.W. Drexler, and H.M. Powell Dehydrothermal crosslinking of electrospun collagen Tissue Eng. C. 17 2011 9 17
103. C. Tang, C.D. Saquing, J.R. Harding, and S.A. Khan In situ cross-linking of electrospun poly(vinyl alcohol) nanofibers Macromolecules 43 2010 630 637
104. R.P. Shaikh, P. Kumar, Y.E. Choonara, L.C. du Toit, and V. Pillay Crosslinked electrospun PVA nanofibrous membranes: elucidation of their physicochemical, physicomechanical and molecular disposition Biofabrication 4 2012
105. Z.X. Meng, X.X. Xu, W. Zheng, H.M. Zhou, L. Li, Y.F. Zheng, and X. Lou Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system Colloid. Surf. B. 84 2011 97 102
106. D.G. Yu, X. Wang, X.Y. Li, W. Chian, Y. Li, and Y.Z. Liao Electrospun biphasic drug release polyvinylpyrrolidone/ethyl cellulose core/sheath nanofibers Acta Biomater. 9 2013 5665 5672
107. L.-Y. Huang, C. Branford-White, X.-X. Shen, D.-G. Yu, and L.-M. Zhu Time-engineeringed biphasic drug release by electrospun nanofiber meshes Int. J. Pharm. 436 2012 88 96
108. Y.-N. Jiang, H.-Y. Mo, and D.-G. Yu Electrospun drug-loaded core-sheath PVP/zein nanofibers for biphasic drug release Int. J. Pharm. 438 2012 232 239
109. T. Okuda, K. Tominaga, and S. Kidoaki Time-programmed dual release formulation by multilayered drug-loaded nanofiber meshes J. Control. Release 143 2010 258 264
110. B. Oh, and C.H. Lee Nanofiber for cardiovascular tissue engineering Expert Opin. Drug Del. 10 2013 1565 1582
111. S.H. Ranganath, and C.-H. Wang Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma Biomaterials 29 2008 2996 3003
112. D. Liu, S. Liu, X. Jing, X. Li, W. Li, and Y. Huang Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats Biomaterials 33 2012 4362 4369
113. X. Luo, C. Xie, H. Wang, C. Liu, S. Yan, and X. Li Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation Int. J. Pharm. 425 2012 19 28