Drug-loaded electrospun materials in wound-dressing applications and in local cancer treatment

Expert Opinion on Drug Delivery

Volumn 10, Issue 4, 2013, Pages 469-483

  Ignatova, Milena ^a   Rashkov, Iliya ^a   Manolova, Nevena ^a  

^a INSTITUTE OF POLYMERS   (Bulgaria)

Author keywords

Antibacterial nanofibers; Anticancer nanofibrous materials; Electrospinning; Local cancer treatment; Wound dressings

Indexed keywords

8 HYDROXY 7 IODO 5 QUINOLINESULFONIC ACID; 8 QUINOLINOL DERIVATIVE; BENZALKONIUM CHLORIDE; BIOMATERIAL; CEFOXITIN; CENTELLA ASIATICA EXTRACT; CHITOSAN; CIPROFLOXACIN; CURCUMIN; DOXORUBICIN; DRUG LOADED ELECTROSPUN MATERIAL; FUSIDIC ACID; GARCINIA COWA EXTRACT; GENTAMICIN; IODINE; ITRACONAZOLE; LEVOFLOXACIN; MOXIFLOXACIN; ORNIDAZOLE; PACLITAXEL; PLANT EXTRACT; POLYCAPROLACTONE; POLYGLACTIN; POVIDONE; PSEUDOMONIC ACID; SILVER NANOPARTICLE; SULFONIC ACID DERIVATIVE; TECOMELLA UNDULATA EXTRACT; TETRACYCLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CANCER SURVIVAL; CANCER THERAPY; CHEMICAL COMPOSITION; DISEASE MODEL; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG RELEASE; ELECTROSPINNING; FIBER; HUMAN; NANOFABRICATION; NONHUMAN; POROSITY; REVIEW; TUMOR VOLUME; WOUND DRESSING; WOUND HEALING;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BANDAGES; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; HUMANS; NANOFIBERS; NEOPLASMS; POROSITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84875182765     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2013.758103     Document Type: Review

References (92)

1. Jayaraman K, Kotaki M, Zhang Y, et al. Recent advances in polymer nanofibers. J Nanosci Nanotech 2004;4:52-65
2. Teo W, Ramakrishna S. A review on electrospinning design and nanofibre assemblies. Nanotechnology 2006;17:89-106
3. Greiner A, Wendorff JH. Functional self-assembled nanofibers by electrospinning. Adv Polym Sci 2008;219:107-71
4. Kriegel C, Arrechi A, Kit K, et al. Fabrication, functionalization, and application of electrospun biopolymer nanofibers. Crit Rev Food Sci Nutrition 2008;48:775-97
5. Huang ZM, Zhang YZ, Kotaki M, et al. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Composites Sci Techn 2003;63:2223-53
6. Andrady AL. Science and technology of polymer nanofibers. John Wiley & Sons, Inc; Hoboken, New Jersey: 2008
7. Paneva D, Ignatova M, Manolova N, Rashkov I. Novel chitosan-containing micro- and nanofibrous materials by electrospinning: Preparation and biomedical application. In: Chang WN, editor. Nanofibers: Fabrication, performance, and applications. Nova Science Publishers, Inc., New York; 2009. p. 73-151
8. Paneva D, Mincheva R, Yancheva E, et al. N-Carboxyethylchitosan-based polymer materials. In: Davis SP, editor. Chitosan: Manufacture, properties, and usage. Nova Science Publishers, Inc., New York; 2011. p. 261-320
9. Agarwal S, Wendorff JH, Greiner A. Use of electrospinning technique for biomedical applications. Polymer (Guildf) 2008;49:5603-21
10. Li D, Xia Y. Electrospinning of nanofibers: Reinventing the wheel? Adv Mater 2004;16:1151-70
11. Zahedi P, Rezaeian I, Ranaei-Siadat S-O, et al. A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polym Adv Technol 2010;21:77-95
12. Shaffer MSP, Sandler JKW. Carbon nanotube and nanofibre reinforced polymer fibres. In: Brown PJ, Stevens K, editors. Nanofibers and nanotechnology in textiles. Woodhead Publishing, Ltd., Cambridge; 2007. p. 194-234
13. Greiner A, Wendorff JH. Electrospinning: A fascinating method for the preparation of ultrathin fibers. Angew Chem Int Ed 2007;46:5670-703
14. Sill TJ, von Recum HA. Electrospinning: Applications in drug delivery and tissue engineering. Biomaterials 2008;29:1989-2006
15. Schiffman JD, Schauer CL. A review: Electrospinning of biopolymer nanofibers and their applications. Polym Rev 2008;48:317-52
16. Hadjiargyrou M, Chiu JB. Enhanced composite electrospun nanofiber scaffolds for use in drug delivery. Expert Opin Drug Deliv 2008;5:1093-106
17. Prabaharan M, Jayakumar R, Nair SV. Electrospun nanofibrous scaffolds-current status and prospects in drug delivery. Adv Polym Sci 2012;246:241-62
18. Sun K, Li ZH. Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning. Expr Polym Lett 2011;5:342-61
19. Bshena O, Heunis TDJ, Dicks LMT, et al. Antimicrobial fibers: Therapeutic possibilities and recent advances. Fut Med Chem 2011;3:1821-47
20. Martinez-Camacho AP, Cortez-Rocha MO, Castillo-Ortega MM, et al. Antimicrobial activity of chitosan nanofibers obtained by electrospinning. Polym Int 2011;60:1663-9
21. Yu D-G, Zhu L-M, White K, et al. Electrospun nanofiber-based drug delivery systems. Health 2009;1:67-75
22. Mahoney C, Mccullough MB, Sankar J, et al. Nanofibrous structure of chitosan for biomedical applications. J Nanomedic Biotherapeu Dis 2012;2:1-9
23. Elsabee MZ, Naguib HF, Morsi RE. Chitosan based nanofibers. Mater Sci Eng C 2012;32:1711-26
24. Jayakumar R, Prabaharan M, Nair SV, et al. Novel chitin and chitosan nanofibers in biomedical applications. Biotechnol Adv 2010;28:142-50
25. Jayakumar R, Prabaharan M, Sudheesh Kumar PT, et al. Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnol Adv 2011;29:322-37
26. Ignatova M, Starbova K, Markova N, et al. Electrospun nano-fibre mats with antibacterial properties from quaternized chitosan and poly(vinyl alcohol). Carbohydr Res 2006;341:2098-107
27. Ignatova M, Manolova N, Rashkov I. Novel antibacterial fibers of quaternized chitosan and poly(vinyl pyrrolidone) prepared by electrospinning. Eur Polym J 2007;43:1112-22
28. Kenawy ER, Layman JM, Watkins JR, et al. Electrospinning of poly(ethyleneco-vinyl alcohol) fibers. Biomaterials 2003;24:907-13
29. Spasova M, Manolova N, Paneva D, et al. Preparation of chitosan-containing nanofibres by electrospinning of chitosan/poly(ethylene oxide) blend solutions. E-Polymers 2004;056:1-12
30. Huang L, Nagapudi K, Apkarian R, et al. Engineered collagen-PEO nanofibers and fabrics. J Biomater Sci Polym Edn 2001;12:979-93
31. Jin HJ, Fridrikh S, Rutledge GC, et al. Electrospinning Bombyx mori silk with poly(ethylene oxide). Am Chem Soc 2002;224:408-9
32. Casper CL, Yamaguchi N, Kiick KL, et al. Functionalizing electrospun fibers with biologically relevant macromolecules. Biomacromolecules 2005;6:1998-2007
33. Kenawy El-R, Bowlin GL, Mansfield K, et al. Release of tetracycline hydrochloride from electrospun poly (ethylene-co-vinylacetate), poly(lactic acid), and a blend. J Control Release 2002;81:57-64
34. Zahedi P, Karami Z, Rezaeian I, et al. Preparation and performance evaluation of tetracycline hydrochloride loaded wound dressing mats based on electrospun nanofibrous poly(lactic acid)/poly("-caprolactone) blends. J Appl Polym Sci 2012;124:4174-83
35. Toncheva A, Paneva D, Maximova V, et al. Antibacterial fluoroquinolone antibiotic-containing fibrous materials from poly(L-lactide-co-D,L-lactide) prepared by electrospinning. Eur J Pharm Sci 2012;47:642-51
36. Kim K, Luu YK, Chang C, et al. Incorporation and controlled release of a hydrophilic antibiotic using poly(lactideco-glycolide)-based electrospun nanofibrous scaffolds. J Control Release 2004;98:47-56
37. Thakur RA, Florek CA, Kohn J, et al. Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing. Int J Pharm 2008;364:87-93
38. B€olgen N, Vargel I, Korkusuz P, et al. In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions. J Biomed Mater Res Part B Appl Biomater 2007;81B:530-43
39. Huang Z-M, He C-L, Yang A, et al. Encapsulating drugs in biodegradable ultrafine fibers through co-axial electrospinning. J Biomed Mater Res 2006;77A:169-79
40. Mincheva R, Paneva D, Manolova N, et al. Preparation of polyelectrolyte-containing nanofibers by electrospinning in the presence of a non-ionogenic water-soluble polymer. J Bioact Compat Polym 2005;20:419-35
41. Verreck G, Chun I, Rosenblatt J, et al. Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer. J Control Release 2003;92:349-60
42. Toncheva A, Paneva D, Manolova N, et al. Electrospun poly(L-lactide) membranes containing a single drug or multiple drug system for antimicrobial wound dressings. Macromol Res 2011;19:1310-19
43. Toncheva A, Spasova M, Paneva D, et al. Drug-loaded electrospun polylactide bundles. J Bioact Compat Polym 2011;26:161-72
44. Suwantong O, Pankongadisak P, Deachathai S, et al. Electrospun poly(Llactic acid) fiber mats containing a crude Garcinia cowa extract for wound dressing applications. J Polym Res 2012;19:1-10
45. Suganya S, Senthil Ram T, Lakshmi BS, et al. Herbal drug incorporated antibacterial nanofibrous mat fabricated by electrospinning: An excellent matrix for wound dressings. J Appl Polym Sci 2011;121:2893-9
46. Suwantong O, Opanasopit P, Ruktanonchai U, et al. Electrospun cellulose acetate fiber mats containing curcumin and release characteristic of the herbal substance. Polymer (Guildf) 2007;48:7546-57
47. Suwantong O, Ruktanonchai U, Supaphol P. Electrospun cellulose acetate fiber mats containing asiaticoside or Centella asiatica crude extract and the release characteristics of asiaticoside. Polymer (Guildf) 2008;49:4239-47
48. Suwantong O, Ruktanonchai U, Supaphol P. In vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin. J Biomed Mater Res Part A 2010;94A:1216-25
49. Said SS, Aloufy AK, El-Halfawy OM, et al. Antimicrobial PLGA ultrafine fibers: Interaction with wound bacteria. Eur J Pharm Biopharm 2011;79:108-18
50. Said SS, El-Halfawy OM, El-Gowelli HM, et al. Bioburden-responsive antimicrobial PLGA ultrafine fibers for wound healing. Eur J Pharm Biopharm 2012;80:85-94
51. Penchev H, Paneva D, Manolova N, et al. Electrospun hybrid nanofibers based on chitosan or N-carboxyethylchitosan and silver nanoparticles. Macromol Biosci 2009;9:884-94
52. Penchev H, Paneva D, Manolova N, et al. Hybrid nanofibrous yarns based on N-carboxyethylchitosan and silver nanoparticles with antibacterial activity prepared by self-bundling electrospinning. Carbohydr Res 2010;345:2374-80
53. Nguyen TTT, Tae B, Park JS. Synthesis and characterization of nanofiber webs of chitosan/poly(vinyl alcohol) blends incorporated with silver nanoparticles. J Mater Sci 2011;46:6528-37
54. Zhao Y, Zhou Y, Wu X, et al. A facile method for electrospinning of Ag nanoparticles/poly (vinyl alcohol)/carboxymethyl-chitosan nanofibers. Appl Surf Sci 2012;258:8867-73
55. Li W, Wang J, Chi H, et al. Preparation and antibacterial activity of polyvinyl alcohol/regenerated silk fibroin composite fibers containing Ag nanoparticles. J Appl Polym Sci 2012;123:20-5
56. Song J, Birbach NL, Hinestroza JP. Deposition of silver nanoparticles on cellulosic fibers via stabilization of carboxymethyl groups. Cellulose 2012;19:411-24
57. Rujitanaroj P, Pimpha N, Supaphol P. Wound-dressing materials with antibacterial activity from electrospun gelatin fiber mats containing silver nanoparticles. Polymer (Guildf) 2008;49:4723-32
58. Chae HH, Kim B-H, Yang KS, et al. Synthesis and antibacterial performance of size-tunable silver nanoparticles with electrospun nanofiber composites. Synth Met 2011;161:2124-8
59. Tijing LD, Ruelo MTG, Amarjargal A, et al. One-step fabrication of antibacterial (silver nanoparticles/poly(ethylene oxide)) -Polyurethane bicomponent hybrid nanofibrous mat by dual-spinneret electrospinning. Mater Chem Phys 2012;134:557-61
60. Duan YY, Jia J, Wang Sh S-H, et al. Preparation of antimicrobial poly("-caprolactone) electrospun nanofibers containing silver-loaded zirconium phosphate nanoparticles. J Appl Polym Sci 2007;106:1208-14
61. Paneva D, Manolova N, Argirova M, et al. Antibacterial electrospun poly("-caprolactone)/ascorbyl palmitate nanofibrous materials. Int J Pharm 2011;416:346-55
62. Okeri H, Arhewoh I. Analytical profile of the fluoroquinolone antibacterials. I. Ofloxacin. Afr J Biotechnol 2008;7:670-80
63. Paul W, Sharma CP. Chitosan and alginate wound dressings: A short review. Trends Biomater Artif Organs 2004;18:18-23
64. Kim CH, Choi JW, Chun HJ, et al. Synthesis of chitosan derivatives with quaternary ammonium salt and their antibacterial activity. Polym Bull 1997;38:387-93
65. Jia Z, Shen D, Xu W. Synthesis and antibacterial activities of quaternary ammonium salt of chitosan. Carbohydr Res 2001;333:1-6
66. Kim JY, Lee JK, Lee TS, et al. Synthesis of chitooligosaccharide derivative with quaternary ammonium group and its antimicrobial activity against Streptococcus mutans. Int J Biol Macromol 2003;32:23-7
67. Ignatova ;, Manolova N, Rashkov I. Electrospun non-woven nanofibrous hybrid mats based on chitosan and PLA for wound-dressing applications. Macromol Biosci 2009;9:102-11
68. Spasova M, Paneva D, Manolova N, et al. Electrospun chitosan-coated fibers of poly(L-lactide) and poly(L-lactide)/poly(ethylene glycol): Preparation and characterization. Macromol Biosci 2008;8:153-62
69. Yancheva E, Paneva D, Manolova N, et al. Tuning of the surface biological behavior of poly(L-lactide)-based electrospun materials by polyelectrolyte complex formation. Biomacromolecules 2010;11:521-32
70. Lee BY, Trainor FS, Thoden WR. Topical application of povidone-iodine in the management of decubitus and stasis ulcers. J Am Geriatr Soc 1979;27:302-6
71. Dedo DD, Alonso WA, Ogura JH. Povidone-iodine: An adjunct in the treatment of wound infections, dehiscences and fistulas in head and neck surgery. Trans Am Acad Ophthalmol Otolaryngol 1977;84:68-74
72. Herndon DN, Curreri PW, Abston S, et al. Treatment of burns. Curr Probl Surg 1987;24:341-97
73. Dekock M, Vandermerue AE, Houghton FC. A new povidone-iodine cream for. treatment of burns -comparison with a. standard topical regimen. S Afr Med J 1986;69:431-5
74. Ignatova M, Manolova N, Rashkov I. Electrospinning of poly(vinyl pyrrolidone)-iodine complex and poly (ethylene oxide)/poly(vinyl pyrrolidone)-iodine complex - a prospective route to antimicrobial wound dressing materials. Eur Polym J 2007;43:1609-23
75. Ignatova M, Markova N, Manolova N, et al. Antibacterial and antimycotic activity of a cross-linked electrospun poly (vinyl pyrrolidone)-iodine complex and a poly(ethylene oxide)/poly(vinyl pyrrolidone)-iodine complex. J Biomater Sci Polymer Edn 2008;19:373-86
76. Janes KA, Fresneau MP, Marazuela A, et al. Chitosan nanoparticles as delivery systems for doxorubicin. J Control Rel 2001;73:255-67
77. Han HD, Song CK, Park YS, et al. A chitosan hydrogel-based cancer drug delivery system exhibits synergistic antitumor effects by combining with a vaccinia viral vaccine. Int J Pharm 2008;350:27-34
78. Park JH, Saravanakumar G, Kim K, et al. Targeted delivery of low molecular drugs using chitosan and its derivatives. Adv Drug Deliv Rev 2010;62:28-41
79. Qin C, Du Y, Xiao L, et al. Enzymic preparation of water-soluble chitosan and their antitumor activity. Int J Biolog Macromol 2002;31:111-17
80. Huang R, Mendis E, Rajapakse N, et al. Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS). Life Sci 2006;78:2399-408
81. Ignatova M, Manolova N, Toshkova R, et al. Electrospun nanofibrous mats containing quaternized chitosan and polylactide with in vitro antitumor activity against HeLa cells. Biomacromolecules 2010;11:1633-45
82. Ignatova M, Yossifova L, Gardeva E, et al. Antiproliferative activity of nanofibers containing quaternized chitosan and/or doxorubicin against MCF-7 human breast carcinoma cell line by apoptosis. J Bioact Compat Polym 2011;26:539-51
83. Toshkova R, Manolova N, Gardeva E, et al. Antitumor efficacy of electrospun nanofibrous implants containing quaternized chitosan and doxorubicin against Graffi myeloid tumor. Int J Pharm 2010;400:221-33
84. Xie J, Wang C-H. Electrospun microand nanofibers for sustained delivery of paclitaxel to treat C6 Glioma in vitro. Pharm Res 2006;23:1817-26
85. Ranganath SH, Wang C-H. Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma. Biomaterials 2008;29:2996-3003
86. Xu X, Chen X, Xu X, et al. BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against Glioma C6 cells. J Control Release 2006;114:307-16
87. Xu X, Chen X, Wang Z, et al. Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity. Eur J Pharm Biopharm 2009;72:18-25
88. Luo X, Xie C, Wang H, et al. Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation. Int J Pharm 2012;425:19-28
89. Suwantong O, Opanasopit P, Ruktanonchai U, et al. Electrospun cellulose acetate fiber mats containing curcumin and release characteristic of the herbal substance. Polymer (Guildf) 2007;48:7546-57
90. Shao S, Li L, Yang G, et al. Controlled green tea polyphenols release from electrospun PCL/MWCNTs composite nanofibers. Int J Pharm 2011;421:310-20
91. Kim Y-J, Park MR, Kim MS, et al. Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells. Mater Chem Phys 2012;133:674-80
92. Ignatova M, Manolova N, Toshkova R, et al. Quaternized chitosan-coated nanofibrous materials containing gossypol: Preparation by electrospinning, characterization and antiproliferative activity towards HeLa cells. Int J Pharm 2012;436:10-24