Gasdermin-B promotes invasion and metastasis in breast cancer cells

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Hergueta Redondo, Marta ^a   Sarrió, David ^a   Molina Crespo, Ángela ^a   Megias, Diego ^b   Mota, Alba ^a   Rojo Sebastian, Alejandro ^c   García Sanz, Pablo ^c   Morales, Saleta ^a   Abril, Sandra ^c   Cano, Amparo ^a   Peinado, Héctor ^d   Moreno Bueno, Gema ^a,c  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b Centro Nacional de Investigations Oncológicas   (Spain)

^c MD ANDERSON CANCER CENTER   (Spain)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GASDERMIN B; HEAT SHOCK PROTEIN 90; PROTEIN CDC42; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR PROMOTER; UNCLASSIFIED DRUG; GELATIN; GSDMB PROTEIN, HUMAN; PROTEIN BINDING; TUMOR PROTEIN;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL LINE; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; CELL INVASION; CELL MOTILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE SILENCING; GENETIC STABILITY; GSDM GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; METASTASIS; MOUSE; NONHUMAN; ONCOGENE; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PROCESSING; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; BREAST TUMOR; CANCER GRADING; CELL MOTION; CELL TRANSFORMATION; DISEASE MODEL; GENE EXPRESSION; GENETICS; INFORMATION PROCESSING; METABOLISM; MIDDLE AGED; MOLECULAR IMAGING; MORTALITY; PAGET NIPPLE DISEASE; PATHOLOGY; PROGNOSIS; PROTEIN DEGRADATION; REPORTER GENE; TUMOR CELL LINE; TUMOR INVASION; VERY ELDERLY; XENOGRAFT;

AGED; AGED, 80 AND OVER; ANIMALS; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL LINE, TUMOR; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; DATASETS AS TOPIC; DISEASE MODELS, ANIMAL; FEMALE; GELATIN; GENE EXPRESSION; GENES, REPORTER; HETEROGRAFTS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MICE; MIDDLE AGED; MOLECULAR IMAGING; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; PHENOTYPE; PROGNOSIS; PROTEIN BINDING; PROTEOLYSIS; RHO GTP-BINDING PROTEINS;

EID: 84899877856     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090099     Document Type: Article

References (42)

1. Sato H, Koide T, Masuya H, Wakana S, Sagai T, et al. (1998) A new mutation Rim3 resembling Re(den) is mapped close to retinoic acid receptor alpha (Rara) gene on mouse chromosome 11. Mamm Genome 9(1):20-5. (Pubitemid 28158988)
2. Saeki N, Kuwahara Y, Sasaki H, Satoh H, Shiroishi T (2000) Gasdermin (Gsdm) localizing to mouse chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Mamm Genome 11:718-724.
3. Lunny DP, Weed E, Nolan PM, Marquardt A, Agustin M, et al. (2005) Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland. J. Invest. Dermatol 124: 615-21. (Pubitemid 40381585)
4. Saeki N, Kim DH, Usui T, Aoyagi K, Tatsuta T, et al. (2007) GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene 26: 6488-98. (Pubitemid 47530599)
5. Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, et al. (2009) Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancer 48(3):261-71.
6. Watabe K, Ito A, Asada H, Endo Y, Kobayashi T, et al. (2001) Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells. J Cancer Res 92:140-51. (Pubitemid 32237092)
7. Carl-McGrath S, Schneider-Stock R, Ebert M, Röcken C (2008) Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues. Pathology 40(1):13-24. (Pubitemid 350172946)
8. Sun Q, Yang J, Xing G, Sun Q, Zhang L, et al. (2008) Expression of GSDML Associates with Tumor Progression in Uterine Cervix Cancer. Transl Oncol 1(2):73-83.
9. Komiyama H, Aoki A, Tanaka S, Maekawa H, Kato Y, et al. (2010) Alu derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB). Genes Genet Syst 85: 75-83.
10. Katoh M, Katoh M (2004) Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon. Int J Oncol 24:75-63.
11. Tamura M, Tanaka S, Fujii T, Aoki A, Komiyama H, et al. (2007) Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics 89: 618-29. (Pubitemid 46604751)
12. Yu J, Kang MJ, Kim BJ, Kwon JW, Song YH, et al. (2011) Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR. Pediatr Pulmonol.46(7):701-8.
13. Moreno-Bueno G, Peinado H, Molina P, Olmeda D, Cubillo E, et al. (2009) The morphological and molecular features of the epithelial-to-mesenchymal transition. Nat Protoc. 4(11):1591-613.
14. Olmeda D, Moreno-Bueno G, Flores JM, Fabra A, Portillo F, et al. (2007) SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells. Cancer Res. 67(24):11721-31.
15. Nascimento CF, de Siqueira AS, Pinheiro JJ, Freitas VM, Jaeger RG (2011) Laminin-111 derived peptides AG73 and C16 regulate invadopodia activity of a human adenoid cystic carcinoma cell line. Exp Cell Res 317: 2562-72.
16. Moreno-Bueno G, Salvador F, Martín A, Floristán A, Cuevas EP, et al. (2011) Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas. EMBO Mol Med 3:528-544.
17. Cancer Genome Atlas Network (2012) Comprehensive molecular portraits of human breast tumours. Nature 490(7418):61-70.
18. Desmedt C, Piette F, Loi S, Wang Y, Lallemand F, et al. (2007) TRANSBIG Consortium. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res 13(11):3207-14. (Pubitemid 46944903)
19. Loi S, Haibe-Kains B, Desmedt C, Wirapati P, Lallemand F, et al. (2008) Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen. BMC Genomics 22;9:239.
20. Pawitan Y, Bjohle J, Amler L, Borg AL, Egyhazi S, et al. (2005) Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res 7:R953-964.
21. Schmidt M, Bohm D, Von Torne C, Steiner E, Puhl A, et al. (2008) The humoral immune system has a key prognostic impact in node-negative breast cancer. Cancer Res 68: 5405-5413.
22. Sotiriou C, Wirapati P, Loi S, Harris A, Fox S, et al. (2006) Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst 98:262-272. (Pubitemid 43264710)
23. Wang Y, Klijn JG, Zhang Y, Sieuwerts AM, Look MP, et al. (2005) Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 365(9460):671-9. (Pubitemid 40260888)
24. van Horssen R, Galjart N, Rens JA, Eggermont AM, ten Hagen TL (2006) Differential effects of matrix and growth factors on endothelial and fibroblast motility: application of a modified cell migration assay. J Cell Biochem 99: 1536-52. (Pubitemid 44845714)
25. Gimona M, Buccione R (2006) Adhesions that mediate invasion. Int J Biochem Cell Biol 38(11):1875-92. (Pubitemid 44425248)
26. Linder S, Wiesner C, Himmel M (2011) Degrading devices: invadosomes in proteolytic cell invasion. Annu Rev Cell Dev Biol 27:185-211.
27. Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y (2004) Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci 101 (20): 7618 7623.
28. Sato S, Fujita N, Tsuruo T (2000) Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci 97(20):10832-7.
29. Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise LV (1997) Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390(6660):632-6. (Pubitemid 28016201)
30. Fritz G, Just I, Kaina B (1999) Rho GTPases are over-expressed in human tumors. Int J Cancer 81(5):682-7. (Pubitemid 29214373)
31. Schnelzer A, Prechtel D, Knaus U, Dehne K, Gerhard M, et al. (2000) Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 19(26):3013-20. (Pubitemid 30389092)
32. Wang HB, Liu XP, Liang J, Yang K, Sui AH, et al. (2009) Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters. Clin Chem Lab Med 47(7):811-7.
33. Kurebayashi J, McLeskey SW, Johnson MD, Lippman ME, Dickson RB, et al. (1993) Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ. Cancer Res 53(9):2178-87. (Pubitemid 23145745)
34. Harrell JC, Dye WW, Allred DC, Jedlicka P, Spoelstra NS, et al. (2006) Estrogen receptor positive breast cancer metastasis: altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes. Cancer Res 66(18):9308-15. (Pubitemid 44521153)
35. Iorns E, Drews-Elger K, Ward TM, Dean S, Clarke J, et al. (2012) A new mouse model for the study of human breast cancer metastasis. PLoS One 7(10):e47995.
36. Yoneda T, Sasaki A, Mundy GR. (1994) Osteolytic bone metastasis in breast cancer. Breast Cancer Res Treat 32(1):73-84. Review. (Pubitemid 24322250)
37. Micalizzi DS, Christensen KL, Jedlicka P, Coletta RD, Barón AE, et al. (2009) The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. J Clin Invest 119(9):2678-90.
38. Whitesell L, Lindquist SL (2005) HSP90 and the chaperoning of cancer. Nat Rev Cancer 5: 761-72. (Pubitemid 41400776)
39. Trepel J, Mollapour M, Giaccone G, Neckers L (2010) Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer 10: 537-49.
40. Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, et al. (2012) Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell 150(5):987-1001.
41. Sin HS, Huh JW, Kim DS, Kang DW, Min DS, et al. (2006) Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells. Arch. Virol 151: 1985-94. (Pubitemid 44440498)
42. Huh JW, Kim DS, Kang DW, Ha HS, Ahn K et al. (2008) Transcriptional regulation of GSDML gene by antisense-oriented HERV-H LTR element. Arch. Virol 153: 1201-5.