Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB)

Genes and Genetic Systems

Volumn 85, Issue 1, 2010, Pages 75-83

  Komiyama, Hiromistu ^a,b   Aoki, Aya ^a,b   Tanaka, Shigekazu ^a   Maekawa, Hiroshi ^b   Kato, Yoriko ^a   Wada, Ryo ^b   Maekawa, Takeo ^b   Tamura, Masaru ^a   Shiroish, Toshihiko ^a  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

Alu; Cis element; Gasdermin family; Gastric cancer; Gsdmb

Indexed keywords

CIS ACTING ELEMENT; GASDERMIN B; TUMOR PROTEIN; UNCLASSIFIED DRUG; GSDMB PROTEIN, HUMAN; IKAROS TRANSCRIPTION FACTOR; IKZF1 PROTEIN, HUMAN; LUCIFERASE; MESSENGER RNA;

ALU SEQUENCE; ARTICLE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; PRECANCER; PROTEIN EXPRESSION; PROTEIN MOTIF; REGULATORY SEQUENCE; REPORTER GENE; SEQUENCE ANALYSIS; STOMACH CANCER; STOMACH CARCINOGENESIS; UPREGULATION; ALTERNATIVE RNA SPLICING; COMPARATIVE STUDY; GENETICS; METABOLISM; PATHOLOGY; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH MUCOSA; STOMACH TUMOR;

ALTERNATIVE SPLICING; ALU ELEMENTS; GASTRIC MUCOSA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IKAROS TRANSCRIPTION FACTOR; LUCIFERASES; NEOPLASM PROTEINS; PROMOTER REGIONS, GENETIC; REGULATORY SEQUENCES, NUCLEIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS;

EID: 77952787002     PISSN: 13417568     EISSN: None     Source Type: Journal    
DOI: 10.1266/ggs.85.75     Document Type: Article

References (22)

1. Batzer, M. A., and Deininger, P. L. (2002) Alu repeats and human genomic diversity. Nat. Rev. Genet. 3, 370-380.
2. Bucher, P. (1990) Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences. J. Mol. Biol. 212, 563-578.
3. Carl-McGrath, S., Schneider-Stock, R., Ebert, M., and Röcken, C. (2008) Differential expression and localisation of gasder- min-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues. Pathology 40, 13-24.
4. Ferrigno, O., Virolle, T., Djabari, Z., Ortonne, J. P., White, R. J., and Aberdam, D. (2001) Transposable B2 SINE elements can provide mobile RNA polymerase II promoter. Nat. Genet. 28, 77-81.
5. Fujii, T., Tamura, M., Tanaka, S., Kato, Y., Yamamoto, H., Mizushina, Y., and Shiroishi, T. (2008) Gasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development. Genesis 46, 418-423.
6. Georgopoulos, K., Bigby, M., Wang, J. H., Molnar, A., Wu, P., Winandy, S., and Sharpe, A. (1994) The Ikaros gene is required for the development of all lymphoid lineages. Cell 79, 143-156.
7. Huh, J. W., Kim, D. S., Kang, D. W., Ha, H. S., Ahn, K., Noh, Y. N., Min, D. S., Chang, K. T., and Kim, H. S. (2008) Transcriptional regulation of GSDML gene by antisense-oriented HERV-H LTR element. Arch. Virol. 153, 1201-1205.
8. Katoh, M., and Katoh, M. (2004a) Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon. Int. J. Oncol. 24, 757-763.
9. Katoh, M., and Katoh, M. (2004b) Identification and character- ization of human DFNA5L, mouse Dfna5l, and rat Dfna5l genes in silico. Int. J. Oncol. 25, 765-770.
10. Lunny, D. P., Weed, E., Nolan, P. M., Marquardt, A., Augustin, M., and Porter, R. M. (2005) Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and seba-ceous gland. J. Invest. Dermatol. 124, 615-621.
11. Runkel, F., Marquardt, A., Stoeger, C., Kochmann, E., Simon, D., Kohnke, B., Korthaus, D., Wattler, F., Fuchs, H., Hrabe de Angelis, M., et al. (2004) The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3. Genomics 84, 824-835.
12. Saeki, N., Kuwahara, Y., Sasaki, H., Sato, H., and Shiroishi, T.(2000) Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Mamm. Genome 11, 718-724.
13. Saeki, N., Kim, D. H., Usui, T., Aoyagi, K., Tatsuta, T., Aoki, K., Yanagihara, K., Tamura, M., Mizushima, H., Sakamoto, H., et al. (2007) GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-b dependent apoptosis signaling. Oncogene 26, 6488-6498.
14. Sasaki, T., Nishihara, H., Hirakawa, M., Fujimura, K., Tanaka, M., Kokubo, N., Kimura-Yoshida, C., Matsuo, I., Sumiyama, K., Saitou, N., et al. (2008) Possible involvement of SINEs in mammalian-specific brain formation. Proc. Natl. Acad. Sci. USA 105, 4220-4225
15. den is mapped close to retinoic acid receptor alpha (Rara) gene on mouse chromosome 11. Mamm. Genome 9, 20-25.
16. Sin, H. S., Huh, J. W., Kim, D. S., Kang, D. W., Min, D. S., Kim, T. H., Ha, H. S., Kim, H. H., Lee, S. Y., and Kim, H. S. (2006) Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells. Arch. Virol. 151, 1985-1994.
17. Sun, Q., Yang, J., Xing, G., Sun, Q., Zhang, L., and He, F. (2008) Expression of GSDML associates with tumor progression in uterine cervix cancer. Transl. Oncol. 1, 73-83.
18. Tamura, M., Tanaka, S., Fujii, T., Aoki, A., Komiyama, H., Ezawa, K., Sumiyama, K., Sagai, T., and Shiroishi, T. (2007) Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics 89, 618-629.
19. Tanaka, S., Tamura, M., Aoki, A., Fujii, T., Komiyama, H., Sagai, T., and Shiroishi, T. (2007) A new Gsdma3 mutation affecting anagen phase of first hair cycle. Biochem. Biophys. Res. Commun. 359, 902-907.
20. The BAC Resource Consortium (2001) Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature 409, 953-958.
21. Watabe, K., Ito, A., Asada, H., Endo, Y., Kobayashi, T., Nakamoto, K., Itami, S., Takao, S., Shinomura, Y., Aikou, T., et al. (2001) Structure, expression, and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells. Jpn. J. Cancer Res. 92, 140-151.
22. Winandy, S., Wu, P., and Georgopoulos, K. (1995) A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 83, 289-299.