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Volumn 42, Issue , 2014, Pages 76-82

Monosodium glutamate neurotoxicity increases beta amyloid in the rat hippocampus: A potential role for cyclic AMP protein kinase

Author keywords

AMPK; Apoptosis; Behavioral; Excitotoxicty; T maze

Indexed keywords

AMYLOID BETA PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; FAS LIGAND; GLUTAMATE SODIUM; PIOGLITAZONE; PLACEBO; 2,4 THIAZOLIDINEDIONE DERIVATIVE; GLUTAMIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

EID: 84899874544     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2014.04.003     Document Type: Article
Times cited : (51)

References (50)
  • 1
    • 0034697213 scopus 로고    scopus 로고
    • Locomotor and learning deficits in adult rats exposed to monosodium-l-glutamate during early life
    • Ali M.M., Bawari M., Misra U.K., Babu G.N. Locomotor and learning deficits in adult rats exposed to monosodium-l-glutamate during early life. Neurosci Lett 2000, 284(1-2):57-60.
    • (2000) Neurosci Lett , vol.284 , Issue.1-2 , pp. 57-60
    • Ali, M.M.1    Bawari, M.2    Misra, U.K.3    Babu, G.N.4
  • 2
    • 0037131060 scopus 로고    scopus 로고
    • Neonatal exposure to monosodium l-glutamate induces loss of neurons and cytoarchitectural alterations in hippocampal CA1 pyramidal neurons of adult rats
    • Beas-Zarate C., Perez-Vega M., Gonzalez-Burgos I. Neonatal exposure to monosodium l-glutamate induces loss of neurons and cytoarchitectural alterations in hippocampal CA1 pyramidal neurons of adult rats. Brain Res 2002, 952(2):275-281.
    • (2002) Brain Res , vol.952 , Issue.2 , pp. 275-281
    • Beas-Zarate, C.1    Perez-Vega, M.2    Gonzalez-Burgos, I.3
  • 3
    • 66149097030 scopus 로고    scopus 로고
    • A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice
    • Becker E.B., Oliver P.L., Glitsch M.D., Banks G.T., Achilli F., Hardy A., et al. A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. Proc Natl Acad Sci U S A 2009, 106(16):6706-6711.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.16 , pp. 6706-6711
    • Becker, E.B.1    Oliver, P.L.2    Glitsch, M.D.3    Banks, G.T.4    Achilli, F.5    Hardy, A.6
  • 5
    • 78649417803 scopus 로고    scopus 로고
    • Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production
    • Bordji K., Becerril-Ortega J., Nicole O., Buisson A. Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production. J Neurosci 2010, 30(47):15927-15942.
    • (2010) J Neurosci , vol.30 , Issue.47 , pp. 15927-15942
    • Bordji, K.1    Becerril-Ortega, J.2    Nicole, O.3    Buisson, A.4
  • 6
    • 0031596284 scopus 로고    scopus 로고
    • Evolution of neuronal changes in the course of Alzheimer's disease
    • Braak H., Braak E. Evolution of neuronal changes in the course of Alzheimer's disease. J Neural Transm Suppl 1998, 53:127-140.
    • (1998) J Neural Transm Suppl , vol.53 , pp. 127-140
    • Braak, H.1    Braak, E.2
  • 7
    • 0015209505 scopus 로고
    • Acute effect of oral and subcutaneous administration of monosodium glutamate on the arcuate nucleus of the hypothalamus in mice and rats
    • Burde R.M., Schainker B., Kayes J. Acute effect of oral and subcutaneous administration of monosodium glutamate on the arcuate nucleus of the hypothalamus in mice and rats. Nature 1971, 233(5314):58-60.
    • (1971) Nature , vol.233 , Issue.5314 , pp. 58-60
    • Burde, R.M.1    Schainker, B.2    Kayes, J.3
  • 8
    • 84863247751 scopus 로고    scopus 로고
    • Down-regulation of amyloid-beta through AMPK activation by inhibitors of GSK-3beta in SH-SY5Y and SH-SY5Y-AbetaPP695 cells
    • Cai Z., Li B., Li K., Zhao B. Down-regulation of amyloid-beta through AMPK activation by inhibitors of GSK-3beta in SH-SY5Y and SH-SY5Y-AbetaPP695 cells. J Alzheimers Dis 2012, 29(1):89-98.
    • (2012) J Alzheimers Dis , vol.29 , Issue.1 , pp. 89-98
    • Cai, Z.1    Li, B.2    Li, K.3    Zhao, B.4
  • 9
    • 33846937529 scopus 로고    scopus 로고
    • An isocratic high performance liquid chromatography method for the determination of GABA and glutamate in discrete regions of the rodent brain
    • Clarke G., O'Mahony S., Malone G., Dinan T.G. An isocratic high performance liquid chromatography method for the determination of GABA and glutamate in discrete regions of the rodent brain. J Neurosci Methods 2007, 160(2):223-230.
    • (2007) J Neurosci Methods , vol.160 , Issue.2 , pp. 223-230
    • Clarke, G.1    O'Mahony, S.2    Malone, G.3    Dinan, T.G.4
  • 11
    • 0034984174 scopus 로고    scopus 로고
    • A comparison of 129S2/SvHsd and C57BL/6JOlaHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice
    • Contet C., Rawlins J.N., Deacon R.M. A comparison of 129S2/SvHsd and C57BL/6JOlaHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice. Behav Brain Res 2001, 124(1):33-46.
    • (2001) Behav Brain Res , vol.124 , Issue.1 , pp. 33-46
    • Contet, C.1    Rawlins, J.N.2    Deacon, R.M.3
  • 12
    • 0019199013 scopus 로고
    • Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
    • Crawley J., Goodwin F.K. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav 1980, 13(2):167-170.
    • (1980) Pharmacol Biochem Behav , vol.13 , Issue.2 , pp. 167-170
    • Crawley, J.1    Goodwin, F.K.2
  • 13
    • 0034803430 scopus 로고    scopus 로고
    • AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation
    • Culmsee C., Monnig J., Kemp B.E., Mattson M.P. AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci 2001, 17(1):45-58.
    • (2001) J Mol Neurosci , vol.17 , Issue.1 , pp. 45-58
    • Culmsee, C.1    Monnig, J.2    Kemp, B.E.3    Mattson, M.P.4
  • 14
    • 80053333126 scopus 로고    scopus 로고
    • APP-based transgenic models: the Tg2576 model
    • Humana Press, New York, P.P. De Deyn, D. Van Dam (Eds.)
    • Deacon R.M.J. APP-based transgenic models: the Tg2576 model. Animal models of dementia 2011, Humana Press, New York. P.P. De Deyn, D. Van Dam (Eds.).
    • (2011) Animal models of dementia
    • Deacon, R.M.J.1
  • 15
    • 0037076481 scopus 로고    scopus 로고
    • Hippocampal cytotoxic lesion effects on species-typical behaviours in mice
    • Deacon R.M., Croucher A., Rawlins J.N. Hippocampal cytotoxic lesion effects on species-typical behaviours in mice. Behav Brain Res 2002, 132(2):203-213.
    • (2002) Behav Brain Res , vol.132 , Issue.2 , pp. 203-213
    • Deacon, R.M.1    Croucher, A.2    Rawlins, J.N.3
  • 16
    • 80054072264 scopus 로고    scopus 로고
    • Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and beta-amyloid in neurons
    • Greco S.J., Hamzelou A., Johnston J.M., Smith M.A., Ashford J.W., Tezapsidis N. Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and beta-amyloid in neurons. Biochem Biophys Res Commun 2011, 414(1):170-174.
    • (2011) Biochem Biophys Res Commun , vol.414 , Issue.1 , pp. 170-174
    • Greco, S.J.1    Hamzelou, A.2    Johnston, J.M.3    Smith, M.A.4    Ashford, J.W.5    Tezapsidis, N.6
  • 17
    • 56149119337 scopus 로고    scopus 로고
    • Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia
    • Grewer C., Gameiro A., Zhang Z., Tao Z., Braams S., Rauen T. Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia. IUBMB Life 2008, 60(9):609-619.
    • (2008) IUBMB Life , vol.60 , Issue.9 , pp. 609-619
    • Grewer, C.1    Gameiro, A.2    Zhang, Z.3    Tao, Z.4    Braams, S.5    Rauen, T.6
  • 18
    • 0034722011 scopus 로고    scopus 로고
    • Increased amyloid precursor protein expression and serotonergic sprouting following excitotoxic lesion of the rat magnocellular nucleus basalis: neuroprotection by Ca(2+) antagonist nimodipine
    • Harkany T., Dijkstra I.M., Oosterink B.J., Horvath K.M., Abraham I., Keijser J., et al. Increased amyloid precursor protein expression and serotonergic sprouting following excitotoxic lesion of the rat magnocellular nucleus basalis: neuroprotection by Ca(2+) antagonist nimodipine. Neuroscience 2000, 101(1):101-114.
    • (2000) Neuroscience , vol.101 , Issue.1 , pp. 101-114
    • Harkany, T.1    Dijkstra, I.M.2    Oosterink, B.J.3    Horvath, K.M.4    Abraham, I.5    Keijser, J.6
  • 19
    • 20444421299 scopus 로고    scopus 로고
    • Behavioral deficits in adult rats treated neonatally with glutamate
    • Hlinak Z., Gandalovicova D., Krejci I. Behavioral deficits in adult rats treated neonatally with glutamate. Neurotoxicol Teratol 2005, 27(3):465-473.
    • (2005) Neurotoxicol Teratol , vol.27 , Issue.3 , pp. 465-473
    • Hlinak, Z.1    Gandalovicova, D.2    Krejci, I.3
  • 20
    • 3042693940 scopus 로고    scopus 로고
    • Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease
    • Hynd M.R., Scott H.L., Dodd P.R. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem Int 2004, 45(5):583-595.
    • (2004) Neurochem Int , vol.45 , Issue.5 , pp. 583-595
    • Hynd, M.R.1    Scott, H.L.2    Dodd, P.R.3
  • 21
    • 0025022272 scopus 로고
    • Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals
    • Ikeda H., Taketomi S., Sugiyama Y., Shimura Y., Sohda T., Meguro K., et al. Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals. Arzneimittelforschung 1990, 40(2 Pt 1):156-162.
    • (1990) Arzneimittelforschung , vol.40 , Issue.2 PART 1 , pp. 156-162
    • Ikeda, H.1    Taketomi, S.2    Sugiyama, Y.3    Shimura, Y.4    Sohda, T.5    Meguro, K.6
  • 22
    • 13644271368 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling
    • Inestrosa N.C., Godoy J.A., Quintanilla R.A., Koenig C.S., Bronfman M. Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling. Exp Cell Res 2005, 304(1):91-104.
    • (2005) Exp Cell Res , vol.304 , Issue.1 , pp. 91-104
    • Inestrosa, N.C.1    Godoy, J.A.2    Quintanilla, R.A.3    Koenig, C.S.4    Bronfman, M.5
  • 23
    • 66549106850 scopus 로고    scopus 로고
    • Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
    • Jack C.R., Lowe V.J., Weigand S.D., Wiste H.J., Senjem M.L., Knopman D.S., et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain 2009, 132(Pt 5):1355-1365.
    • (2009) Brain , vol.132 , Issue.PART 5 , pp. 1355-1365
    • Jack, C.R.1    Lowe, V.J.2    Weigand, S.D.3    Wiste, H.J.4    Senjem, M.L.5    Knopman, D.S.6
  • 24
    • 33645912949 scopus 로고    scopus 로고
    • Development of neurological reflexes and motor coordination in rats neonatally treated with monosodium glutamate
    • Kiss P., Tamas A., Lubics A., Szalai M., Szalontay L., Lengvari I., et al. Development of neurological reflexes and motor coordination in rats neonatally treated with monosodium glutamate. Neurotox Res 2005, 8(3-4):235-244.
    • (2005) Neurotox Res , vol.8 , Issue.3-4 , pp. 235-244
    • Kiss, P.1    Tamas, A.2    Lubics, A.3    Szalai, M.4    Szalontay, L.5    Lengvari, I.6
  • 25
    • 26844574739 scopus 로고    scopus 로고
    • NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production
    • Lesne S., Ali C., Gabriel C., Croci N., MacKenzie E.T., Glabe C.G., et al. NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. J Neurosci 2005, 25(41):9367-9377.
    • (2005) J Neurosci , vol.25 , Issue.41 , pp. 9367-9377
    • Lesne, S.1    Ali, C.2    Gabriel, C.3    Croci, N.4    MacKenzie, E.T.5    Glabe, C.G.6
  • 26
    • 75849163307 scopus 로고    scopus 로고
    • Monosodium glutamate neonatal treatment as a seizure and excitotoxic model
    • Lopez-Perez S.J., Urena-Guerrero M.E., Morales-Villagran A. Monosodium glutamate neonatal treatment as a seizure and excitotoxic model. Brain Res 2010, 1317:246-256.
    • (2010) Brain Res , vol.1317 , pp. 246-256
    • Lopez-Perez, S.J.1    Urena-Guerrero, M.E.2    Morales-Villagran, A.3
  • 27
  • 28
    • 84871919598 scopus 로고    scopus 로고
    • Excitotoxicity: bridge to various triggers in neurodegenerative disorders
    • Mehta A., Prabhakar M., Kumar P., Deshmukh R., Sharma P.L. Excitotoxicity: bridge to various triggers in neurodegenerative disorders. Eur J Pharmacol 2013, 698(1-3):6-18.
    • (2013) Eur J Pharmacol , vol.698 , Issue.1-3 , pp. 6-18
    • Mehta, A.1    Prabhakar, M.2    Kumar, P.3    Deshmukh, R.4    Sharma, P.L.5
  • 29
    • 0034065936 scopus 로고    scopus 로고
    • Glutamate as a neurotransmitter in the brain: review of physiology and pathology
    • Meldrum B.S. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000, 130(4S Suppl.):1007S-1015S.
    • (2000) J Nutr , vol.130 , Issue.4 S SUPPL.
    • Meldrum, B.S.1
  • 30
    • 84878366818 scopus 로고    scopus 로고
    • Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice
    • Moon H.S., Dincer F., Mantzoros C.S. Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice. Diabetologia 2013, 56(3):627-634.
    • (2013) Diabetologia , vol.56 , Issue.3 , pp. 627-634
    • Moon, H.S.1    Dincer, F.2    Mantzoros, C.S.3
  • 31
    • 0035478618 scopus 로고    scopus 로고
    • Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand
    • Morishima Y., Gotoh Y., Zieg J., Barrett T., Takano H., Flavell R., et al. Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J Neurosci 2001, 21(19):7551-7560.
    • (2001) J Neurosci , vol.21 , Issue.19 , pp. 7551-7560
    • Morishima, Y.1    Gotoh, Y.2    Zieg, J.3    Barrett, T.4    Takano, H.5    Flavell, R.6
  • 32
    • 66549127860 scopus 로고    scopus 로고
    • Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    • Mormino E.C., Kluth J.T., Madison C.M., Rabinovici G.D., Baker S.L., Miller B.L., et al. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain 2009, 132(Pt 5):1310-1323.
    • (2009) Brain , vol.132 , Issue.PART 5 , pp. 1310-1323
    • Mormino, E.C.1    Kluth, J.T.2    Madison, C.M.3    Rabinovici, G.D.4    Baker, S.L.5    Miller, B.L.6
  • 33
    • 57649178152 scopus 로고    scopus 로고
    • Role of N-methyl-d-aspartate receptors in polychlorinated biphenyl mediated neurotoxicity
    • Ndountse L.T., Chan H.M. Role of N-methyl-d-aspartate receptors in polychlorinated biphenyl mediated neurotoxicity. Toxicol Lett 2009, 184(1):50-55.
    • (2009) Toxicol Lett , vol.184 , Issue.1 , pp. 50-55
    • Ndountse, L.T.1    Chan, H.M.2
  • 34
    • 0014668762 scopus 로고
    • Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate
    • Olney J.W. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 1969, 164(3880):719-721.
    • (1969) Science , vol.164 , Issue.3880 , pp. 719-721
    • Olney, J.W.1
  • 36
    • 0018394639 scopus 로고
    • Minimal tissue concentrations of glutamate required to produce necrosis of hypothalamic neurons in newborn mice
    • Perez V.J., Olney J.W., Martin J.F., Cannon W.O. Minimal tissue concentrations of glutamate required to produce necrosis of hypothalamic neurons in newborn mice. Biol Neonate 1979, 35(1-2):17-22.
    • (1979) Biol Neonate , vol.35 , Issue.1-2 , pp. 17-22
    • Perez, V.J.1    Olney, J.W.2    Martin, J.F.3    Cannon, W.O.4
  • 37
    • 2542503439 scopus 로고    scopus 로고
    • NMDA and AMPA receptor expression and cortical neuronal death are associated with p38 in glutamate-induced excitotoxicity in vivo
    • Rivera-Cervantes M.C., Torres J.S., Feria-Velasco A., Armendariz-Borunda J., Beas-Zarate C. NMDA and AMPA receptor expression and cortical neuronal death are associated with p38 in glutamate-induced excitotoxicity in vivo. J Neurosci Res 2004, 76(5):678-687.
    • (2004) J Neurosci Res , vol.76 , Issue.5 , pp. 678-687
    • Rivera-Cervantes, M.C.1    Torres, J.S.2    Feria-Velasco, A.3    Armendariz-Borunda, J.4    Beas-Zarate, C.5
  • 38
    • 0036827161 scopus 로고    scopus 로고
    • Abeta as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease
    • Robinson S.R., Bishop G.M. Abeta as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease. Neurobiol Aging 2002, 23(6):1051-1072.
    • (2002) Neurobiol Aging , vol.23 , Issue.6 , pp. 1051-1072
    • Robinson, S.R.1    Bishop, G.M.2
  • 39
    • 79960566233 scopus 로고    scopus 로고
    • AMP-activated protein kinase: a potential player in Alzheimer's disease
    • Salminen A., Kaarniranta K., Haapasalo A., Soininen H., Hiltunen M. AMP-activated protein kinase: a potential player in Alzheimer's disease. J Neurochem 2011, 118(4):460-474.
    • (2011) J Neurochem , vol.118 , Issue.4 , pp. 460-474
    • Salminen, A.1    Kaarniranta, K.2    Haapasalo, A.3    Soininen, H.4    Hiltunen, M.5
  • 41
    • 84865443163 scopus 로고    scopus 로고
    • Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase
    • Shen J.Z., Ma L.N., Han Y., Liu J.X., Yang W.Q., Chen L., et al. Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase. Diabetologia 2012, 55(6):1836-1846.
    • (2012) Diabetologia , vol.55 , Issue.6 , pp. 1836-1846
    • Shen, J.Z.1    Ma, L.N.2    Han, Y.3    Liu, J.X.4    Yang, W.Q.5    Chen, L.6
  • 42
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
    • Tanzi R.E., Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 2005, 120(4):545-555.
    • (2005) Cell , vol.120 , Issue.4 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 43
    • 48249111737 scopus 로고    scopus 로고
    • Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury
    • Tehranian R., Rose M.E., Vagni V., Pickrell A.M., Griffith R.P., Liu H., et al. Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury. J Neurotrauma 2008, 25(7):755-767.
    • (2008) J Neurotrauma , vol.25 , Issue.7 , pp. 755-767
    • Tehranian, R.1    Rose, M.E.2    Vagni, V.3    Pickrell, A.M.4    Griffith, R.P.5    Liu, H.6
  • 44
    • 77950575506 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism
    • Vingtdeux V., Giliberto L., Zhao H., Chandakkar P., Wu Q., Simon J.E., et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem 2010, 285(12):9100-9113.
    • (2010) J Biol Chem , vol.285 , Issue.12 , pp. 9100-9113
    • Vingtdeux, V.1    Giliberto, L.2    Zhao, H.3    Chandakkar, P.4    Wu, Q.5    Simon, J.E.6
  • 45
    • 79251556232 scopus 로고    scopus 로고
    • Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation
    • Vingtdeux V., Chandakkar P., Zhao H., d'Abramo C., Davies P., Marambaud P. Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation. FASEB J 2011, 25(1):219-231.
    • (2011) FASEB J , vol.25 , Issue.1 , pp. 219-231
    • Vingtdeux, V.1    Chandakkar, P.2    Zhao, H.3    d'Abramo, C.4    Davies, P.5    Marambaud, P.6
  • 46
    • 75549092259 scopus 로고    scopus 로고
    • Amyloid beta from axons and dendrites reduces local spine number and plasticity
    • Wei W., Nguyen L.N., Kessels H.W., Hagiwara H., Sisodia S., Malinow R. Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat Neurosci 2010, 13(2):190-196.
    • (2010) Nat Neurosci , vol.13 , Issue.2 , pp. 190-196
    • Wei, W.1    Nguyen, L.N.2    Kessels, H.W.3    Hagiwara, H.4    Sisodia, S.5    Malinow, R.6
  • 47
    • 84896706419 scopus 로고    scopus 로고
    • Memantine in patients with moderate to severe Alzheimer's disease: meta-analyses using realistic definitions of response
    • Wilkinson D., Wirth Y., Goebel C. Memantine in patients with moderate to severe Alzheimer's disease: meta-analyses using realistic definitions of response. Dement Geriatr Cogn Disord 2014, 37(1-2):71-85.
    • (2014) Dement Geriatr Cogn Disord , vol.37 , Issue.1-2 , pp. 71-85
    • Wilkinson, D.1    Wirth, Y.2    Goebel, C.3
  • 48
    • 77956267203 scopus 로고    scopus 로고
    • Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis
    • Won J.S., Im Y.B., Kim J., Singh A.K., Singh I. Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis. Biochem Biophys Res Commun 2010, 399(4):487-491.
    • (2010) Biochem Biophys Res Commun , vol.399 , Issue.4 , pp. 487-491
    • Won, J.S.1    Im, Y.B.2    Kim, J.3    Singh, A.K.4    Singh, I.5
  • 49
    • 13944275183 scopus 로고    scopus 로고
    • Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w
    • Yao M., Nguyen T.V., Pike C.J. Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. J Neurosci 2005, 25(5):1149-1158.
    • (2005) J Neurosci , vol.25 , Issue.5 , pp. 1149-1158
    • Yao, M.1    Nguyen, T.V.2    Pike, C.J.3
  • 50
    • 84870286570 scopus 로고    scopus 로고
    • Thiazolidinediones improve hepatic fibrosis in rats with non-alcoholic steatohepatitis by activating the adenosine monophosphate-activated protein kinase signalling pathway
    • Zhang W., Wu R., Zhang F., Xu Y., Liu B., Yang Y., et al. Thiazolidinediones improve hepatic fibrosis in rats with non-alcoholic steatohepatitis by activating the adenosine monophosphate-activated protein kinase signalling pathway. Clin Exp Pharmacol Physiol 2012, 39(12):1026-1033.
    • (2012) Clin Exp Pharmacol Physiol , vol.39 , Issue.12 , pp. 1026-1033
    • Zhang, W.1    Wu, R.2    Zhang, F.3    Xu, Y.4    Liu, B.5    Yang, Y.6


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